Bosentan (hydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0895634
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0496209
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0459615
AKAP12 A kinase (PRKA) anchor protein 12 0.0456571
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.032383
EGFR epidermal growth factor receptor 0.0319845
COL6A3 collagen, type VI, alpha 3 0.0310683
HILPDA hypoxia inducible lipid droplet-associated 0.030322
ZNF841 zinc finger protein 841 0.0273502
GRB10 growth factor receptor-bound protein 10 0.0271375
CADM1 cell adhesion molecule 1 0.0264294
MMP12 matrix metallopeptidase 12 0.0254679
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0245986
FAM13A family with sequence similarity 13, member A 0.0245867
DTNA dystrobrevin, alpha 0.0231875
HELZ helicase with zinc finger 0.0231814
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.022578
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0224594
IGFBP5 insulin-like growth factor binding protein 5 0.0215557
ADARB1 adenosine deaminase, RNA-specific, B1 0.0210922
SRP54 signal recognition particle 54kDa 0.0208592
ACBD3 acyl-CoA binding domain containing 3 0.0207046
ZNF160 zinc finger protein 160 0.0195246
FNIP1 folliculin interacting protein 1 0.0195193
ERRFI1 ERBB receptor feedback inhibitor 1 0.0194896
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0192076
IGFBP3 insulin-like growth factor binding protein 3 0.0189524
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0186742
ANKRD36 ankyrin repeat domain 36 0.0182412
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0181886
PDIA3 protein disulfide isomerase family A, member 3 0.0181771
CD109 CD109 molecule 0.0180254
ATP13A3 ATPase type 13A3 0.0179193
ESYT2 extended synaptotagmin-like protein 2 0.0178726
ZCCHC7 zinc finger, CCHC domain containing 7 0.0177735
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0175115
JARID2 jumonji, AT rich interactive domain 2 0.0171607
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0170464
TMF1 TATA element modulatory factor 1 0.0169178
NUP58 nucleoporin 58 0.0168935
SUCO SUN domain containing ossification factor 0.01678
CXCL8 chemokine (C-X-C motif) ligand 8 0.0162288
COG5 component of oligomeric golgi complex 5 0.0160421
TFRC transferrin receptor 0.0157393
CEMIP cell migration inducing protein, hyaluronan binding 0.0153452
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0152202
FXR1 fragile X mental retardation, autosomal homolog 1 0.0150384
GPR173 G protein-coupled receptor 173 0.014611
RAB6A RAB6A, member RAS oncogene family 0.014527
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0144374
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0144368
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0144139
PDIA6 protein disulfide isomerase family A, member 6 0.0142947
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0142531
TMEM39A transmembrane protein 39A 0.0140229
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0139281
TTC3 tetratricopeptide repeat domain 3 0.0139093
SDK1 sidekick cell adhesion molecule 1 0.0138342
GOLGA4 golgin A4 0.0137621
SEC23A Sec23 homolog A (S. cerevisiae) 0.0137131
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0136673
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0135949
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0134313
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0132973
BACE2 beta-site APP-cleaving enzyme 2 0.0131977
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0131162
NGLY1 N-glycanase 1 0.0130947
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0130749
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.013043
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0129796
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0129352
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0127965
CLEC1B C-type lectin domain family 1, member B 0.0123199
DISC1 disrupted in schizophrenia 1 0.0121765
FN1 fibronectin 1 0.0120784
GSK3B glycogen synthase kinase 3 beta 0.0120408
CANX calnexin 0.0120295
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0117764
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0117682
SEC24A SEC24 family member A 0.011707
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0116534
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0116276
NCK1 NCK adaptor protein 1 0.0115449
RLF rearranged L-myc fusion 0.0115424
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0115349
N4BP2L2 NEDD4 binding protein 2-like 2 0.011362
SCFD2 sec1 family domain containing 2 0.0113291
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0113015
COG6 component of oligomeric golgi complex 6 0.0112938
MIMS1 mitochondrial inner membrane scaffold 1 0.0112704
CEP152 centrosomal protein 152kDa 0.0112128
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0111753
AATF apoptosis antagonizing transcription factor 0.0111079
ARHGAP21 Rho GTPase activating protein 21 0.0110614
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.0110317
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0110216
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.0110097
ELP2 elongator acetyltransferase complex subunit 2 0.0109713
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.010955
LOX lysyl oxidase 0.0108931

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.397413
FTL ferritin, light polypeptide -0.166078
MT2A metallothionein 2A -0.122545
CD44 CD44 molecule (Indian blood group) -0.11947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11434
TGFBI transforming growth factor, beta-induced, 68kDa -0.0901865
TMSB10 thymosin beta 10 -0.0780666
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.07084
VIM vimentin -0.0633345
OSMR oncostatin M receptor -0.0632204
FNDC3B fibronectin type III domain containing 3B -0.061944
ANXA2 annexin A2 -0.0553125
GLIS3 GLIS family zinc finger 3 -0.0552548
SMAD3 SMAD family member 3 -0.0532686
NDRG1 N-myc downstream regulated 1 -0.0528352
RPL28 ribosomal protein L28 -0.05192
NAMPT nicotinamide phosphoribosyltransferase -0.0504006
AHNAK AHNAK nucleoprotein -0.0502924
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0494136
RTN4 reticulon 4 -0.0476993
ASPH aspartate beta-hydroxylase -0.0474631
STK17A serine/threonine kinase 17a -0.0447292
RPL35A ribosomal protein L35a -0.0445451
LOC112694756 uncharaterized LOC112694756 -0.0437987
TXNRD1 thioredoxin reductase 1 -0.0430337
MT1X metallothionein 1X -0.0428305
ACTN4 actinin, alpha 4 -0.0421294
KYNU kynureninase -0.0411555
EIF1 eukaryotic translation initiation factor 1 -0.0406082
SQSTM1 sequestosome 1 -0.040401
RPS6 ribosomal protein S6 -0.0404009
VCL vinculin -0.0398862
RPS8 ribosomal protein S8 -0.039573
TRIO trio Rho guanine nucleotide exchange factor -0.0389886
DGKD diacylglycerol kinase, delta 130kDa -0.0388879
RPLP1 ribosomal protein, large, P1 -0.0388058
RUNX1 runt-related transcription factor 1 -0.038026
TNNC1 troponin C type 1 (slow) -0.0373322
ATXN1 ataxin 1 -0.0363396
PKM pyruvate kinase, muscle -0.0353229
MAP1B microtubule-associated protein 1B -0.0345278
RPL34 ribosomal protein L34 -0.0341175
RPS19 ribosomal protein S19 -0.0340842
WWTR1 WW domain containing transcription regulator 1 -0.0332464
EGR1 early growth response 1 -0.0330019
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0316084
TPT1 tumor protein, translationally-controlled 1 -0.0316055
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0313568
LPP LIM domain containing preferred translocation partner in lipoma -0.0311425
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0305958
TNS3 tensin 3 -0.0305427
RACK1 receptor for activated C kinase 1 -0.0300596
RPLP2 ribosomal protein, large, P2 -0.0295523
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0291098
EXT1 exostosin glycosyltransferase 1 -0.0291058
FLNA filamin A, alpha -0.0287052
NALF1 NALCN channel auxiliary factor 1 -0.028454
SEC61G Sec61 gamma subunit -0.0283791
FUS FUS RNA binding protein -0.0283592
PDE4D phosphodiesterase 4D, cAMP-specific -0.0274008
RPL12 ribosomal protein L12 -0.0273718
RPL31 ribosomal protein L31 -0.0272666
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0272642
NCOA7 nuclear receptor coactivator 7 -0.0263181
HLA-B major histocompatibility complex, class I, B -0.0261259
IL6ST interleukin 6 signal transducer -0.0257586
TUBB tubulin, beta class I -0.0255526
ANKRD11 ankyrin repeat domain 11 -0.0253034
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0251304
RPL37A ribosomal protein L37a -0.0251065
PHF14 PHD finger protein 14 -0.0249899
RPS12 ribosomal protein S12 -0.0247969
PALLD palladin, cytoskeletal associated protein -0.0247316
GNAS GNAS complex locus -0.02469
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0244371
TPM4 tropomyosin 4 -0.0244046
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0243613
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0242718
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0242418
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.024143
FTH1 ferritin, heavy polypeptide 1 -0.0240171
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0240136
RPLP0 ribosomal protein, large, P0 -0.0238837
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0238168
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0236205
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0231562
RPS21 ribosomal protein S21 -0.0229886
ZBTB20 zinc finger and BTB domain containing 20 -0.022971
HLA-C major histocompatibility complex, class I, C -0.0223792
RPS11 ribosomal protein S11 -0.0220527
RPL9 ribosomal protein L9 -0.0220451
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0219221
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0217984
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0217454
RPS20 ribosomal protein S20 -0.021251
RPL19 ribosomal protein L19 -0.0210812
VDAC1 voltage-dependent anion channel 1 -0.0210072
LOXL2 lysyl oxidase-like 2 -0.0208787
GARS1 glycyl-tRNA synthetase 1 -0.0207698
NAV3 neuron navigator 3 -0.020765