| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.145942 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0751213 |
| GOLGA4 | golgin A4 | 0.0677226 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0553912 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0547912 |
| NUP58 | nucleoporin 58 | 0.0546351 |
| TMF1 | TATA element modulatory factor 1 | 0.0545943 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0472935 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0425481 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0422658 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0405904 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0374236 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0359721 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.034066 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0338561 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0328549 |
| RNF24 | ring finger protein 24 | 0.0327726 |
| RPL21 | ribosomal protein L21 | 0.0324163 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0323846 |
| YEATS2 | YEATS domain containing 2 | 0.031391 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0304779 |
| HELZ | helicase with zinc finger | 0.0300598 |
| RPS2 | ribosomal protein S2 | 0.0296248 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0292985 |
| RPS12 | ribosomal protein S12 | 0.0286072 |
| CDK19 | cyclin-dependent kinase 19 | 0.0273165 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0270477 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0269648 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0266013 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0265024 |
| PRELID2 | PRELI domain containing 2 | 0.0256997 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0238437 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0238049 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0236399 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0234107 |
| PEX3 | peroxisomal biogenesis factor 3 | 0.0234094 |
| INSIG2 | insulin induced gene 2 | 0.0230965 |
| RPS3 | ribosomal protein S3 | 0.0226522 |
| OGA | O-GlcNAcase | 0.0224483 |
| ZNF654 | zinc finger protein 654 | 0.0222307 |
| RIOK3 | RIO kinase 3 | 0.022078 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0219772 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0214517 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0214479 |
| RNF145 | ring finger protein 145 | 0.021239 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.021233 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0211273 |
| RUNX1 | runt-related transcription factor 1 | 0.0206645 |
| NEBL | nebulette | 0.0202761 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0201425 |
| FAM162A | family with sequence similarity 162, member A | 0.0201321 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0200434 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0199995 |
| COG6 | component of oligomeric golgi complex 6 | 0.0197147 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0195742 |
| ATF4 | activating transcription factor 4 | 0.0193627 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0193469 |
| FAM13A | family with sequence similarity 13, member A | 0.0193189 |
| USP37 | ubiquitin specific peptidase 37 | 0.0192136 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0190939 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0190394 |
| ZNF638 | zinc finger protein 638 | 0.0190019 |
| RPS18 | ribosomal protein S18 | 0.0188072 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0187013 |
| FOXO3 | forkhead box O3 | 0.0185414 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0184592 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0179009 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0178795 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0178043 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.017571 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0175455 |
| RPL3 | ribosomal protein L3 | 0.0174162 |
| SPAG9 | sperm associated antigen 9 | 0.0173301 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0172758 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0172712 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.0171096 |
| ZNF292 | zinc finger protein 292 | 0.0170381 |
| ENO1 | enolase 1, (alpha) | 0.0168843 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0166293 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0166024 |
| ARRDC3 | arrestin domain containing 3 | 0.0165426 |
| RPL37A | ribosomal protein L37a | 0.0164391 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0162991 |
| CEP152 | centrosomal protein 152kDa | 0.0162403 |
| SRP54 | signal recognition particle 54kDa | 0.0161793 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0159287 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0159138 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0158853 |
| PGM3 | phosphoglucomutase 3 | 0.0158819 |
| CCNL1 | cyclin L1 | 0.0156751 |
| VEGFA | vascular endothelial growth factor A | 0.0156715 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.015641 |
| ZNF160 | zinc finger protein 160 | 0.0154495 |
| UBA5 | ubiquitin-like modifier activating enzyme 5 | 0.0147934 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0147345 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0146872 |
| MKRN1 | makorin ring finger protein 1 | 0.0146833 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0146537 |
| FBXO42 | F-box protein 42 | 0.0145867 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0143583 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.374341 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.254297 |
| AHNAK | AHNAK nucleoprotein | -0.209778 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.123363 |
| PTMA | prothymosin, alpha | -0.120768 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0817684 |
| PKM | pyruvate kinase, muscle | -0.0771224 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0761342 |
| TPM4 | tropomyosin 4 | -0.0748295 |
| KRT8 | keratin 8, type II | -0.0711539 |
| TXNRD1 | thioredoxin reductase 1 | -0.0705887 |
| KRT18 | keratin 18, type I | -0.0697166 |
| TENM3 | teneurin transmembrane protein 3 | -0.0693621 |
| TMSB10 | thymosin beta 10 | -0.0688533 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.067974 |
| EZR | ezrin | -0.067499 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0672061 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0662335 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0653059 |
| VCL | vinculin | -0.0649935 |
| FHIT | fragile histidine triad | -0.0635192 |
| EGR1 | early growth response 1 | -0.0625499 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0588761 |
| MED13L | mediator complex subunit 13-like | -0.0579385 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.056925 |
| ARF4 | ADP-ribosylation factor 4 | -0.0566865 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0564838 |
| ACTN4 | actinin, alpha 4 | -0.0562572 |
| MKI67 | marker of proliferation Ki-67 | -0.0556374 |
| ACTG1 | actin gamma 1 | -0.0537245 |
| FUS | FUS RNA binding protein | -0.0532183 |
| SERINC5 | serine incorporator 5 | -0.0498389 |
| FRMD5 | FERM domain containing 5 | -0.048522 |
| ANXA2 | annexin A2 | -0.0475505 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0471502 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0464836 |
| MSI2 | musashi RNA-binding protein 2 | -0.0459828 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0457097 |
| POTEF | POTE ankyrin domain family, member F | -0.0446993 |
| HDLBP | high density lipoprotein binding protein | -0.0443714 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0439092 |
| WWOX | WW domain containing oxidoreductase | -0.0430559 |
| EXOC4 | exocyst complex component 4 | -0.0428933 |
| TCF12 | transcription factor 12 | -0.0428433 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0423986 |
| CCND1 | cyclin D1 | -0.0414919 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0413409 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0409081 |
| ZNRF3 | zinc and ring finger 3 | -0.0393566 |
| HOXB3 | homeobox B3 | -0.0392654 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0392234 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0391492 |
| RRBP1 | ribosome binding protein 1 | -0.0390556 |
| TUBB | tubulin, beta class I | -0.0386683 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0381779 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0377322 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0371503 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0362647 |
| APP | amyloid beta (A4) precursor protein | -0.036145 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.036139 |
| CD2AP | CD2-associated protein | -0.0355293 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0352137 |
| SUMF1 | sulfatase modifying factor 1 | -0.0348085 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0347318 |
| TBC1D4 | TBC1 domain family, member 4 | -0.0342753 |
| CADPS | Ca++-dependent secretion activator | -0.0340343 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0337924 |
| HMGA1 | high mobility group AT-hook 1 | -0.0337595 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.033304 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0330942 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0328572 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0326024 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0324918 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0320273 |
| NF1 | neurofibromin 1 | -0.0317591 |
| ZFHX3 | zinc finger homeobox 3 | -0.0316814 |
| RNF213 | ring finger protein 213 | -0.0314487 |
| CUX1 | cut-like homeobox 1 | -0.0308266 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0306693 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0306148 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0305837 |
| ARF1 | ADP-ribosylation factor 1 | -0.0302988 |
| RNF43 | ring finger protein 43 | -0.02984 |
| ACACA | acetyl-CoA carboxylase alpha | -0.029489 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0294612 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0291942 |
| TUBA1B | tubulin, alpha 1b | -0.0290993 |
| SQSTM1 | sequestosome 1 | -0.0289199 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.0288852 |
| CTBP2 | C-terminal binding protein 2 | -0.028857 |
| NDRG1 | N-myc downstream regulated 1 | -0.0287997 |
| EHBP1 | EH domain binding protein 1 | -0.0286666 |
| SH3BP4 | SH3-domain binding protein 4 | -0.0286341 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0282901 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0281222 |
| KRT19 | keratin 19, type I | -0.0278352 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.027586 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.027582 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0274411 |
| MYO9A | myosin IXA | -0.0272141 |
