Bosentan (hydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.086981
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0640668
ZNF292 zinc finger protein 292 0.0569441
MYH9 myosin, heavy chain 9, non-muscle 0.0567157
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0558647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0545203
PRELID2 PRELI domain containing 2 0.0484376
FTH1 ferritin, heavy polypeptide 1 0.0479013
FXR1 fragile X mental retardation, autosomal homolog 1 0.047434
HELZ helicase with zinc finger 0.0465646
NCKAP1 NCK-associated protein 1 0.0455937
SNX9 sorting nexin 9 0.0449917
FNDC3B fibronectin type III domain containing 3B 0.0398545
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0392946
RYBP RING1 and YY1 binding protein 0.0386562
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0373809
USP9X ubiquitin specific peptidase 9, X-linked 0.0371117
KDM6A lysine (K)-specific demethylase 6A 0.036288
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354976
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0350804
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0343052
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0338575
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0327291
TRA2A transformer 2 alpha homolog (Drosophila) 0.0317821
ZNF207 zinc finger protein 207 0.0311113
MATR3 matrin 3 0.0294418
RPL3 ribosomal protein L3 0.0290149
RLF rearranged L-myc fusion 0.0289015
MED13L mediator complex subunit 13-like 0.0288113
ADAM9 ADAM metallopeptidase domain 9 0.0285658
CCNL1 cyclin L1 0.0278793
YAP1 Yes-associated protein 1 0.0270402
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0269589
AFDN afadin, adherens junction formation factor 0.0265748
NRIP1 nuclear receptor interacting protein 1 0.0265426
WAC WW domain containing adaptor with coiled-coil 0.0262945
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0259512
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0259225
CDC73 cell division cycle 73 0.0259065
TFG TRK-fused gene 0.0257187
MEMO1 mediator of cell motility 1 0.0255261
PUM1 pumilio RNA-binding family member 1 0.0249954
SFPQ splicing factor proline/glutamine-rich 0.0246481
SMAD3 SMAD family member 3 0.0246344
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.024527
YEATS2 YEATS domain containing 2 0.0244493
WDFY3 WD repeat and FYVE domain containing 3 0.0238648
FUBP1 far upstream element (FUSE) binding protein 1 0.0236822
TOP2B topoisomerase (DNA) II beta 180kDa 0.0235176
UBQLN1 ubiquilin 1 0.0234014
TRIO trio Rho guanine nucleotide exchange factor 0.0230745
ZNF638 zinc finger protein 638 0.0227968
ANXA11 annexin A11 0.0225337
NAMPT nicotinamide phosphoribosyltransferase 0.0222983
PICALM phosphatidylinositol binding clathrin assembly protein 0.0222728
USP3 ubiquitin specific peptidase 3 0.0220706
STRN3 striatin, calmodulin binding protein 3 0.0220048
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0219079
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0217988
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0216507
INSIG2 insulin induced gene 2 0.0215039
MSI2 musashi RNA-binding protein 2 0.0213029
TCERG1 transcription elongation regulator 1 0.0213
ZNF148 zinc finger protein 148 0.0209557
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0209248
KIAA1328 KIAA1328 0.0206181
SLC35F5 solute carrier family 35, member F5 0.0205075
OSBPL9 oxysterol binding protein-like 9 0.0204741
APP amyloid beta (A4) precursor protein 0.0204737
RBM33 RNA binding motif protein 33 0.0203075
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0202558
NUP58 nucleoporin 58 0.0201755
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0201186
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0201045
AHCTF1 AT hook containing transcription factor 1 0.0200917
SRPK2 SRSF protein kinase 2 0.0200138
MACROD2 MACRO domain containing 2 0.0198717
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0196742
IPO7 importin 7 0.0195954
NBAS neuroblastoma amplified sequence 0.0195843
DIAPH1 diaphanous-related formin 1 0.0195143
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0195015
FAM13B family with sequence similarity 13, member B 0.019417
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0193928
ANKRD17 ankyrin repeat domain 17 0.0191039
PTK2 protein tyrosine kinase 2 0.018777
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187338
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0187255
ZNF644 zinc finger protein 644 0.0186254
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0183087
AKAP13 A kinase (PRKA) anchor protein 13 0.0182792
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0182662
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0181224
ATP13A3 ATPase type 13A3 0.0181178
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0180601
RANBP2 RAN binding protein 2 0.0180487
SPOPL speckle-type POZ protein-like 0.0178262
CD46 CD46 molecule, complement regulatory protein 0.0173153
SCARB2 scavenger receptor class B, member 2 0.0171832
SMAD4 SMAD family member 4 0.0170248

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.230934
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.143827
FTL ferritin, light polypeptide -0.135911
TMSB10 thymosin beta 10 -0.113462
PAX8 paired box 8 -0.105463
RPL35A ribosomal protein L35a -0.0988282
TPT1 tumor protein, translationally-controlled 1 -0.089736
RPS8 ribosomal protein S8 -0.0893261
LAMB3 laminin, beta 3 -0.0843822
ALCAM activated leukocyte cell adhesion molecule -0.0843494
B2M beta-2-microglobulin -0.0821123
ASPH aspartate beta-hydroxylase -0.0793142
RPS19 ribosomal protein S19 -0.0783484
RPL23 ribosomal protein L23 -0.0748944
RPS3 ribosomal protein S3 -0.0717115
PTMA prothymosin, alpha -0.0685867
RPL31 ribosomal protein L31 -0.0655773
RPLP2 ribosomal protein, large, P2 -0.0589377
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0587469
RPL19 ribosomal protein L19 -0.0579015
RPS27A ribosomal protein S27a -0.0577304
ANXA2 annexin A2 -0.056248
RACK1 receptor for activated C kinase 1 -0.0518308
RPL37A ribosomal protein L37a -0.0515358
CREB5 cAMP responsive element binding protein 5 -0.0513827
LAMC2 laminin, gamma 2 -0.0484721
ENO1 enolase 1, (alpha) -0.0481862
TPM4 tropomyosin 4 -0.0476362
RPL9 ribosomal protein L9 -0.0465994
RPL35 ribosomal protein L35 -0.0456695
HMGA1 high mobility group AT-hook 1 -0.0450589
TMSB4X thymosin beta 4, X-linked -0.0446049
RPS6 ribosomal protein S6 -0.0439619
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0431781
RPS14 ribosomal protein S14 -0.0428903
RPL12 ribosomal protein L12 -0.0426403
RPL26 ribosomal protein L26 -0.0425086
RPS29 ribosomal protein S29 -0.04099
RPS12 ribosomal protein S12 -0.040787
S100A9 S100 calcium binding protein A9 -0.0405801
MKI67 marker of proliferation Ki-67 -0.0403843
FLNB filamin B, beta -0.0400289
BICD1 bicaudal D homolog 1 (Drosophila) -0.0397804
DLC1 DLC1 Rho GTPase activating protein -0.0392588
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0390634
RPL18 ribosomal protein L18 -0.0390344
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0384973
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0376874
RPS16 ribosomal protein S16 -0.0376234
ITGB8 integrin, beta 8 -0.0375292
RPL36 ribosomal protein L36 -0.0366814
EIF1 eukaryotic translation initiation factor 1 -0.0362139
HMGA2 high mobility group AT-hook 2 -0.0359584
RPL7A ribosomal protein L7a -0.0355725
LIMCH1 LIM and calponin homology domains 1 -0.0355578
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0353746
ZBTB20 zinc finger and BTB domain containing 20 -0.0349892
TPI1 triosephosphate isomerase 1 -0.0349145
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0346224
H1-0 H1.0 linker histone -0.0339771
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0338847
PTPRF protein tyrosine phosphatase, receptor type, F -0.0338124
RPL32 ribosomal protein L32 -0.0337763
MT1X metallothionein 1X -0.0331892
RPS27 ribosomal protein S27 -0.0327504
VCAN versican -0.0320481
AHNAK AHNAK nucleoprotein -0.0317098
LDHA lactate dehydrogenase A -0.031537
EGFR epidermal growth factor receptor -0.0310678
MYOF myoferlin -0.0307036
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0304696
ARHGAP29 Rho GTPase activating protein 29 -0.0303716
SVIL supervillin -0.0301244
CD44 CD44 molecule (Indian blood group) -0.0299847
RPL10A ribosomal protein L10a -0.0298045
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0296207
ANXA3 annexin A3 -0.0293015
CCDC138 coiled-coil domain containing 138 -0.0292232
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0291134
RPS13 ribosomal protein S13 -0.0282634
RPS17 ribosomal protein S17 -0.0281807
RPL37 ribosomal protein L37 -0.0278551
EZR ezrin -0.0265064
VCL vinculin -0.0264402
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0263952
S100A6 S100 calcium binding protein A6 -0.0261549
VIM vimentin -0.0260928
RPL36A ribosomal protein L36a -0.0260111
UBXN4 UBX domain protein 4 -0.0260096
KAZN kazrin, periplakin interacting protein -0.0259409
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0257879
RPL7 ribosomal protein L7 -0.0254361
LAMA4 laminin, alpha 4 -0.0252857
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0252508
RPL27A ribosomal protein L27a -0.0247981
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.024757
RPS5 ribosomal protein S5 -0.0247377
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0243497
CANX calnexin -0.0243247
MAML2 mastermind-like 2 (Drosophila) -0.0241932