| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133653 |
| FAM13A | family with sequence similarity 13, member A | 0.126582 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0875927 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0860863 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0714476 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0667413 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0653997 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0647604 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0604541 |
| DTNA | dystrobrevin, alpha | 0.0599006 |
| ZNF292 | zinc finger protein 292 | 0.058526 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0585083 |
| GOLGA4 | golgin A4 | 0.0583264 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0544537 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0535035 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0516015 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0473615 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0461421 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0457158 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0448903 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0447706 |
| PTK2 | protein tyrosine kinase 2 | 0.0446774 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0429878 |
| NGLY1 | N-glycanase 1 | 0.0422238 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0416367 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0411211 |
| ASPH | aspartate beta-hydroxylase | 0.041118 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0408633 |
| ENO1 | enolase 1, (alpha) | 0.0407211 |
| SPAG9 | sperm associated antigen 9 | 0.0407034 |
| ATP13A3 | ATPase type 13A3 | 0.0398039 |
| HELZ | helicase with zinc finger | 0.0397538 |
| RNF145 | ring finger protein 145 | 0.0396461 |
| INSIG2 | insulin induced gene 2 | 0.0392163 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0385196 |
| USP3 | ubiquitin specific peptidase 3 | 0.0385139 |
| NUP58 | nucleoporin 58 | 0.0380743 |
| CD109 | CD109 molecule | 0.0378959 |
| PDE10A | phosphodiesterase 10A | 0.0358005 |
| ZNF148 | zinc finger protein 148 | 0.0343302 |
| RUNX1 | runt-related transcription factor 1 | 0.0333346 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0332897 |
| RLF | rearranged L-myc fusion | 0.0327033 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0319109 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0315503 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0300778 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0299305 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0298384 |
| ADM | adrenomedullin | 0.029663 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.029557 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0293083 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.02912 |
| CDH13 | cadherin 13 | 0.0291117 |
| PGK1 | phosphoglycerate kinase 1 | 0.0290624 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0285167 |
| BBX | bobby sox homolog (Drosophila) | 0.0279461 |
| RBM39 | RNA binding motif protein 39 | 0.0272502 |
| TFG | TRK-fused gene | 0.0268886 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0267866 |
| SETD5 | SET domain containing 5 | 0.0267481 |
| MMP12 | matrix metallopeptidase 12 | 0.0265616 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0263308 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0263284 |
| MYO1B | myosin IB | 0.0262963 |
| OGA | O-GlcNAcase | 0.0261635 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.025191 |
| CANX | calnexin | 0.0251387 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0249876 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0248837 |
| ARRDC3 | arrestin domain containing 3 | 0.0244908 |
| FAM162A | family with sequence similarity 162, member A | 0.0243233 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0240984 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0240005 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0239483 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0233872 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0229485 |
| MEF2A | myocyte enhancer factor 2A | 0.0228329 |
| TAC4 | tachykinin 4 (hemokinin) | 0.022698 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0223561 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0222125 |
| WDR45B | WD repeat domain 45B | 0.0221374 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0218592 |
| MATR3 | matrin 3 | 0.021806 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0216941 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0216387 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0212387 |
| QKI | QKI, KH domain containing, RNA binding | 0.0212087 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0211513 |
| SNX9 | sorting nexin 9 | 0.0211388 |
| NBAS | neuroblastoma amplified sequence | 0.0209395 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0207797 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0204243 |
| CDC73 | cell division cycle 73 | 0.020173 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0201316 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.020097 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0197971 |
| PRELID2 | PRELI domain containing 2 | 0.0197467 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0195071 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0195042 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0194242 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.425176 |
| CD44 | CD44 molecule (Indian blood group) | -0.215797 |
| FN1 | fibronectin 1 | -0.129042 |
| HMGA2 | high mobility group AT-hook 2 | -0.126817 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.122358 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.117989 |
| VIM | vimentin | -0.116135 |
| VCL | vinculin | -0.0961796 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0909661 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0769387 |
| EGR1 | early growth response 1 | -0.0738883 |
| GLIS3 | GLIS family zinc finger 3 | -0.0738334 |
| MT2A | metallothionein 2A | -0.0727104 |
| TMSB10 | thymosin beta 10 | -0.0714823 |
| IGF2 | insulin-like growth factor 2 | -0.0677692 |
| ACTG1 | actin gamma 1 | -0.0675882 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0662256 |
| NAV1 | neuron navigator 1 | -0.0497331 |
| ACTN4 | actinin, alpha 4 | -0.0471985 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0471464 |
| CCND1 | cyclin D1 | -0.0458663 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0434208 |
| AHNAK | AHNAK nucleoprotein | -0.0433542 |
| LOX | lysyl oxidase | -0.0429336 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0422866 |
| OSMR | oncostatin M receptor | -0.0419352 |
| COL5A1 | collagen, type V, alpha 1 | -0.0384307 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0373261 |
| PLEC | plectin | -0.0369051 |
| FLNA | filamin A, alpha | -0.0351284 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0347898 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0347384 |
| LOXL2 | lysyl oxidase-like 2 | -0.0336317 |
| TNNC1 | troponin C type 1 (slow) | -0.0332437 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0324392 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.031966 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0315215 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0299871 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.029473 |
| EGFR | epidermal growth factor receptor | -0.0293913 |
| ACTN1 | actinin, alpha 1 | -0.0292669 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0291264 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0281729 |
| BPTF | bromodomain PHD finger transcription factor | -0.0280572 |
| CLIC4 | chloride intracellular channel 4 | -0.0269722 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0264625 |
| DUSP6 | dual specificity phosphatase 6 | -0.0263783 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0261714 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0259695 |
| TENM2 | teneurin transmembrane protein 2 | -0.0258868 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0248205 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0244003 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0243002 |
| MAP1B | microtubule-associated protein 1B | -0.0241157 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0240948 |
| SEPTIN9 | septin 9 | -0.0238011 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.023663 |
| RAI14 | retinoic acid induced 14 | -0.0235999 |
| NDRG1 | N-myc downstream regulated 1 | -0.0232397 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0229753 |
| TGFB1 | transforming growth factor, beta 1 | -0.0227481 |
| TUBB6 | tubulin, beta 6 class V | -0.0224393 |
| RRBP1 | ribosome binding protein 1 | -0.0222361 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0221456 |
| PALLD | palladin, cytoskeletal associated protein | -0.0218835 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0214187 |
| NABP1 | nucleic acid binding protein 1 | -0.0213687 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0207354 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0203759 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0203495 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0200893 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0192359 |
| FTL | ferritin, light polypeptide | -0.0190571 |
| MLPH | melanophilin | -0.0185422 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0185386 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0185142 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | -0.0185035 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0178422 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0178304 |
| MT1X | metallothionein 1X | -0.0177041 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0176265 |
| CD82 | CD82 molecule | -0.0175499 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.0175074 |
| NUP98 | nucleoporin 98kDa | -0.017146 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0171052 |
| MRC2 | mannose receptor, C type 2 | -0.0170032 |
| IL11 | interleukin 11 | -0.0169044 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.016709 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0165561 |
| ETV6 | ets variant 6 | -0.0163586 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0162493 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0162148 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0160017 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0159892 |
| HDLBP | high density lipoprotein binding protein | -0.0159595 |
| SVIL | supervillin | -0.0158415 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0158134 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0157071 |
| GOLGB1 | golgin B1 | -0.0156312 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0156227 |
