Bosentan (hydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP13A3 ATPase type 13A3 0.1838
CXCL8 chemokine (C-X-C motif) ligand 8 0.144722
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.143339
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.127601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0937155
LDHA lactate dehydrogenase A 0.068734
COL1A1 collagen, type I, alpha 1 0.0631269
POSTN periostin, osteoblast specific factor 0.0626034
MYH9 myosin, heavy chain 9, non-muscle 0.0588612
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0547381
NAMPT nicotinamide phosphoribosyltransferase 0.0538475
ARRDC3 arrestin domain containing 3 0.0536155
STC1 stanniocalcin 1 0.0531592
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0521579
RASA2 RAS p21 protein activator 2 0.0504316
COL1A2 collagen, type I, alpha 2 0.0501573
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0484558
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0480975
UBC ubiquitin C 0.0474424
FTH1 ferritin, heavy polypeptide 1 0.0470138
SPAG9 sperm associated antigen 9 0.044874
ERRFI1 ERBB receptor feedback inhibitor 1 0.0443118
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0412236
USP3 ubiquitin specific peptidase 3 0.0409031
DPYSL3 dihydropyrimidinase-like 3 0.0382573
PDIA3 protein disulfide isomerase family A, member 3 0.0380741
ADAM17 ADAM metallopeptidase domain 17 0.0379402
ELL2 elongation factor, RNA polymerase II, 2 0.0372943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0362774
SMAD3 SMAD family member 3 0.0361332
CANX calnexin 0.0345565
RLF rearranged L-myc fusion 0.0343522
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0334856
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0324887
VCAN versican 0.0323052
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0320055
PDIA6 protein disulfide isomerase family A, member 6 0.0312661
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0309304
LAMB1 laminin, beta 1 0.0308901
APP amyloid beta (A4) precursor protein 0.0308745
SKIC3 SKI3 subunit of superkiller complex 0.030791
ZNF292 zinc finger protein 292 0.0304473
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0296797
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0296211
SQLE squalene epoxidase 0.0291657
FXR1 fragile X mental retardation, autosomal homolog 1 0.0290211
CSF1 colony stimulating factor 1 (macrophage) 0.0287647
TFG TRK-fused gene 0.0283186
ZNF148 zinc finger protein 148 0.0281171
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0273432
RAD21 RAD21 homolog (S. pombe) 0.0270462
ENO1 enolase 1, (alpha) 0.0268863
ADAM9 ADAM metallopeptidase domain 9 0.0268545
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0266536
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0260828
COG5 component of oligomeric golgi complex 5 0.0258988
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0258258
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0255535
PTK2 protein tyrosine kinase 2 0.0251726
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0248172
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239869
RPL3 ribosomal protein L3 0.0239126
DLG1 discs, large homolog 1 (Drosophila) 0.0237898
KDM7A lysine (K)-specific demethylase 7A 0.0234457
GSK3B glycogen synthase kinase 3 beta 0.0234192
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0224741
DSTN destrin (actin depolymerizing factor) 0.0221166
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0217181
FAM168A family with sequence similarity 168, member A 0.0212272
DENND4C DENN/MADD domain containing 4C 0.0211116
CCDC50 coiled-coil domain containing 50 0.0209578
HSPA8 heat shock 70kDa protein 8 0.0209298
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0208444
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0203919
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0203544
INSIG2 insulin induced gene 2 0.0202338
SRSF4 serine/arginine-rich splicing factor 4 0.0202281
CD2AP CD2-associated protein 0.02006
NCKAP1 NCK-associated protein 1 0.0200186
FNBP1L formin binding protein 1-like 0.0199481
ESYT2 extended synaptotagmin-like protein 2 0.019807
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0197229
NRIP1 nuclear receptor interacting protein 1 0.0196641
SNX9 sorting nexin 9 0.0195389
COL4A1 collagen, type IV, alpha 1 0.0195374
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0195039
PLAUR plasminogen activator, urokinase receptor 0.0195002
CD59 CD59 molecule, complement regulatory protein 0.019357
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0193213
IL1B interleukin 1, beta 0.0192839
MSMO1 methylsterol monooxygenase 1 0.0191882
CLINT1 clathrin interactor 1 0.0190049
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0186467
IL6 interleukin 6 0.0186451
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0185159
DOCK7 dedicator of cytokinesis 7 0.018298
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0181039
IGFBP7 insulin-like growth factor binding protein 7 0.0179987
MTSS1 metastasis suppressor 1 0.0178655
TMEM123 transmembrane protein 123 0.0176606

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.231046
MT2A metallothionein 2A -0.183363
COL5A1 collagen, type V, alpha 1 -0.132239
TIMP3 TIMP metallopeptidase inhibitor 3 -0.128148
EXT1 exostosin glycosyltransferase 1 -0.110878
CDH13 cadherin 13 -0.107724
COL6A3 collagen, type VI, alpha 3 -0.10204
TGFBI transforming growth factor, beta-induced, 68kDa -0.101483
IER3 immediate early response 3 -0.0794613
CADM1 cell adhesion molecule 1 -0.0743208
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.073726
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0727581
FBN1 fibrillin 1 -0.065463
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0561907
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0559334
RPL35A ribosomal protein L35a -0.0542994
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0540258
RPS19 ribosomal protein S19 -0.0530832
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0525744
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0517407
TMSB10 thymosin beta 10 -0.0514737
COL7A1 collagen, type VII, alpha 1 -0.0511581
LOX lysyl oxidase -0.0504279
SQSTM1 sequestosome 1 -0.0491927
RPS3 ribosomal protein S3 -0.0491797
TTC3 tetratricopeptide repeat domain 3 -0.0490798
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0487806
RUNX1 runt-related transcription factor 1 -0.0485763
JARID2 jumonji, AT rich interactive domain 2 -0.0484921
EGFR epidermal growth factor receptor -0.0480549
PDIA5 protein disulfide isomerase family A, member 5 -0.0475334
RPS8 ribosomal protein S8 -0.0472323
IARS1 isoleucyl-tRNA synthetase 1 -0.0463615
GOLGB1 golgin B1 -0.046193
ARF4 ADP-ribosylation factor 4 -0.0457433
VCL vinculin -0.0454411
DST dystonin -0.0453451
RPL37A ribosomal protein L37a -0.0451779
IGFBP3 insulin-like growth factor binding protein 3 -0.0447503
ABI3BP ABI family, member 3 (NESH) binding protein -0.043962
FGFR1 fibroblast growth factor receptor 1 -0.0432464
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0420674
HM13 histocompatibility (minor) 13 -0.0420255
ATXN1 ataxin 1 -0.0418609
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0410996
PTPRG protein tyrosine phosphatase, receptor type, G -0.0410886
TRIO trio Rho guanine nucleotide exchange factor -0.0408037
COL6A2 collagen, type VI, alpha 2 -0.0399119
RPLP2 ribosomal protein, large, P2 -0.0393661
FTL ferritin, light polypeptide -0.0383459
AHNAK AHNAK nucleoprotein -0.0382368
DOCK5 dedicator of cytokinesis 5 -0.0381572
SPDYA speedy/RINGO cell cycle regulator family member A -0.0376962
VIM vimentin -0.0371027
EGR1 early growth response 1 -0.0369796
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0357364
RPS12 ribosomal protein S12 -0.0355132
SEC31A SEC31 homolog A (S. cerevisiae) -0.0345933
CAVIN1 caveolae associated protein 1 -0.0342305
CDK13 cyclin-dependent kinase 13 -0.0342235
MTDH metadherin -0.0335879
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0333312
TGFB1 transforming growth factor, beta 1 -0.0332452
KDM4B lysine (K)-specific demethylase 4B -0.0330725
RAB2A RAB2A, member RAS oncogene family -0.0330432
HSPG2 heparan sulfate proteoglycan 2 -0.0324067
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0323158
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0317262
CALD1 caldesmon 1 -0.0316205
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0314566
SON SON DNA binding protein -0.0312278
CUX1 cut-like homeobox 1 -0.0311823
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0309648
COL6A1 collagen, type VI, alpha 1 -0.0307948
ZFPM2 zinc finger protein, FOG family member 2 -0.0307871
NABP1 nucleic acid binding protein 1 -0.0307602
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0303579
FNIP1 folliculin interacting protein 1 -0.0298925
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0298592
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0297293
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0296238
SRSF11 serine/arginine-rich splicing factor 11 -0.0290968
LOXL2 lysyl oxidase-like 2 -0.0290688
LMNA lamin A/C -0.0290275
NEK10 NIMA-related kinase 10 -0.0289098
SEC24D SEC24 family member D -0.028659
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0286168
AP3D1 adaptor-related protein complex 3, delta 1 subunit -0.02861
RRBP1 ribosome binding protein 1 -0.0283989
SEC24A SEC24 family member A -0.0282445
RPL23 ribosomal protein L23 -0.0281646
RPS27A ribosomal protein S27a -0.0278591
ACTN1 actinin, alpha 1 -0.0277903
FLNA filamin A, alpha -0.0277892
ACTG1 actin gamma 1 -0.0276676
RPL5 ribosomal protein L5 -0.0275497
GNAS GNAS complex locus -0.0273915
PDLIM5 PDZ and LIM domain 5 -0.0273685
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0272781
EEF2 eukaryotic translation elongation factor 2 -0.027257