Bosentan (hydrate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0247025
OGA O-GlcNAcase 0.0204163
KDM6A lysine (K)-specific demethylase 6A 0.0193702
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0169845
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.016683
ZMYM2 zinc finger, MYM-type 2 0.0164371
NCKAP1 NCK-associated protein 1 0.0159715
NAMPT nicotinamide phosphoribosyltransferase 0.0141227
EREG epiregulin 0.0127614
RAD21 RAD21 homolog (S. pombe) 0.0123915
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0123163
RB1CC1 RB1-inducible coiled-coil 1 0.0119081
NEK7 NIMA-related kinase 7 0.011863
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0115362
SERINC1 serine incorporator 1 0.0108104
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0103265
CKAP5 cytoskeleton associated protein 5 0.0103065
USP3 ubiquitin specific peptidase 3 0.01023
CAPRIN1 cell cycle associated protein 1 0.0100411
UBQLN1 ubiquilin 1 0.00978123
CAMTA1 calmodulin binding transcription activator 1 0.00973981
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00946486
PDZD8 PDZ domain containing 8 0.00939939
BRWD3 bromodomain and WD repeat domain containing 3 0.00928762
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.00928758
SBF2 SET binding factor 2 0.00919295
SUCO SUN domain containing ossification factor 0.00916233
WDR26 WD repeat domain 26 0.009146
ADAM17 ADAM metallopeptidase domain 17 0.00914336
ZNF841 zinc finger protein 841 0.009108
TM9SF3 transmembrane 9 superfamily member 3 0.00901239
FAR1 fatty acyl CoA reductase 1 0.00898394
TENT2 terminal nucleotidyltransferase 2 0.00893137
PUM2 pumilio RNA-binding family member 2 0.00892456
ANLN anillin, actin binding protein 0.00889688
ANO6 anoctamin 6 0.00870089
NCAPG2 non-SMC condensin II complex, subunit G2 0.00860051
ANKRD36 ankyrin repeat domain 36 0.00852513
CDC73 cell division cycle 73 0.00852088
EFR3A EFR3 homolog A (S. cerevisiae) 0.00841824
AFDN afadin, adherens junction formation factor 0.00841493
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00839492
CUL3 cullin 3 0.00837147
TES testin LIM domain protein 0.00824328
SMYD3 SET and MYND domain containing 3 0.0082316
USP9X ubiquitin specific peptidase 9, X-linked 0.00820405
PRPF4B pre-mRNA processing factor 4B 0.00819116
OSBPL9 oxysterol binding protein-like 9 0.00811899
SLC35F5 solute carrier family 35, member F5 0.00779923
KDM3A lysine (K)-specific demethylase 3A 0.00775597
CEP192 centrosomal protein 192kDa 0.00770635
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.00770325
RBM26 RNA binding motif protein 26 0.00769544
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00768144
CARD16 caspase recruitment domain family, member 16 0.00762347
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.00758605
NBAS neuroblastoma amplified sequence 0.00756905
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.00753019
EHF ets homologous factor 0.00752575
DIAPH3 diaphanous-related formin 3 0.00751217
THOC1 THO complex 1 0.00750779
GCLC glutamate-cysteine ligase, catalytic subunit 0.00745437
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.00745174
STX16 syntaxin 16 0.00743439
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00736255
CDK8 cyclin-dependent kinase 8 0.00727022
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.00726564
FANCI Fanconi anemia, complementation group I 0.00724724
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.00723575
COG5 component of oligomeric golgi complex 5 0.00721419
PTBP2 polypyrimidine tract binding protein 2 0.00719108
ZFC3H1 zinc finger, C3H1-type containing 0.00715253
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00714713
CREBRF CREB3 regulatory factor 0.00712453
RNF169 ring finger protein 169 0.00712383
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00706408
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00702021
USP12 ubiquitin specific peptidase 12 0.00695842
TAS2R14 taste receptor, type 2, member 14 0.00692265
USPL1 ubiquitin specific peptidase like 1 0.00690855
WDR37 WD repeat domain 37 0.00690626
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00686144
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.00682152
TFG TRK-fused gene 0.00678129
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.00674916
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00668933
TRIO trio Rho guanine nucleotide exchange factor 0.00668375
MON2 MON2 homolog (S. cerevisiae) 0.00666969
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00666011
TNPO1 transportin 1 0.0066469
HSPA8 heat shock 70kDa protein 8 0.00653984
NRIP1 nuclear receptor interacting protein 1 0.00653785
ARRDC3 arrestin domain containing 3 0.00649454
PNN pinin, desmosome associated protein 0.00648023
ICE1 interactor of little elongation complex ELL subunit 1 0.00646611
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00644093
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.00643678
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.00643589
RCOR3 REST corepressor 3 0.00642499
DIDO1 death inducer-obliterator 1 0.0064059

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.174214
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159764
NDRG1 N-myc downstream regulated 1 -0.151746
TPT1 tumor protein, translationally-controlled 1 -0.137785
RPS6 ribosomal protein S6 -0.130391
PTMA prothymosin, alpha -0.126179
TMSB10 thymosin beta 10 -0.115169
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.110415
MYH14 myosin, heavy chain 14, non-muscle -0.107881
FTH1 ferritin, heavy polypeptide 1 -0.102969
LOC102724023 ES1 protein homolog, mitochondrial -0.0998152
RPLP1 ribosomal protein, large, P1 -0.0968423
RPS19 ribosomal protein S19 -0.0891731
ACTG1 actin gamma 1 -0.0855571
RPS8 ribosomal protein S8 -0.0731672
RPL23 ribosomal protein L23 -0.072686
RPL35A ribosomal protein L35a -0.0697842
EGR1 early growth response 1 -0.0674048
B2M beta-2-microglobulin -0.066988
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.061365
RPLP2 ribosomal protein, large, P2 -0.0595454
RPL34 ribosomal protein L34 -0.0574512
ANXA2 annexin A2 -0.057337
RPS3 ribosomal protein S3 -0.0530782
PKM pyruvate kinase, muscle -0.0525666
RPS11 ribosomal protein S11 -0.052255
S100A10 S100 calcium binding protein A10 -0.051523
LYZ lysozyme -0.0512648
RPS13 ribosomal protein S13 -0.0510323
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0510167
ACTN4 actinin, alpha 4 -0.0509094
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0494164
ITPKC inositol-trisphosphate 3-kinase C -0.0477518
RPL28 ribosomal protein L28 -0.0470643
KRT19 keratin 19, type I -0.0456945
RPS21 ribosomal protein S21 -0.0453226
LMNA lamin A/C -0.0452722
S100A6 S100 calcium binding protein A6 -0.0444655
RPS16 ribosomal protein S16 -0.0439066
RPS12 ribosomal protein S12 -0.0436222
KRT20 keratin 20, type I -0.0430945
RPL11 ribosomal protein L11 -0.0427235
RPL8 ribosomal protein L8 -0.0414247
FRY furry homolog (Drosophila) -0.0410935
RPS5 ribosomal protein S5 -0.0405986
RPS23 ribosomal protein S23 -0.0405243
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.040389
ASTN2 astrotactin 2 -0.0400223
RPS25 ribosomal protein S25 -0.0398021
EZR ezrin -0.0394492
RPL31 ribosomal protein L31 -0.0392957
KRT8 keratin 8, type II -0.039228
TJP1 tight junction protein 1 -0.0392211
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0388409
KRT18 keratin 18, type I -0.0382672
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0381765
TMC5 transmembrane channel-like 5 -0.037848
WASF2 WAS protein family, member 2 -0.0377111
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0375202
RPL9 ribosomal protein L9 -0.0374666
RPL18 ribosomal protein L18 -0.0373394
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0372713
LOC112694756 uncharaterized LOC112694756 -0.0368335
LMO7 LIM domain 7 -0.0363324
RPLP0 ribosomal protein, large, P0 -0.0362881
RPS24 ribosomal protein S24 -0.0361845
RPL5 ribosomal protein L5 -0.0353056
P4HB prolyl 4-hydroxylase, beta polypeptide -0.034592
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0344881
RPL27A ribosomal protein L27a -0.0343076
TRIB1 tribbles pseudokinase 1 -0.0340227
GMDS GDP-mannose 4,6-dehydratase -0.0338531
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0338393
SERF2 small EDRK-rich factor 2 -0.0334209
EIF1 eukaryotic translation initiation factor 1 -0.033326
CNRIP1 cannabinoid receptor interacting protein 1 -0.0330763
RPL12 ribosomal protein L12 -0.0328626
MYL12B myosin, light chain 12B, regulatory -0.0328605
RPL13A ribosomal protein L13a -0.0327839
RPS14 ribosomal protein S14 -0.0323441
POTEF POTE ankyrin domain family, member F -0.0319019
MYO1E myosin IE -0.0317312
HMGA1 high mobility group AT-hook 1 -0.0315776
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0315231
RPS17 ribosomal protein S17 -0.0313396
RPL36A ribosomal protein L36a -0.0311196
RNF213 ring finger protein 213 -0.0310044
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0308837
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0306753
BPTF bromodomain PHD finger transcription factor -0.0305887
S100P S100 calcium binding protein P -0.0305139
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0304475
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0303257
JUN jun proto-oncogene -0.0302432
RPS27 ribosomal protein S27 -0.0302216
RPS27A ribosomal protein S27a -0.0299941
RPL37A ribosomal protein L37a -0.0292078
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0291126
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0288392
RPL37 ribosomal protein L37 -0.0284782