Bosentan (hydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.122208
ERRFI1 ERBB receptor feedback inhibitor 1 0.104255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0982544
FNDC3B fibronectin type III domain containing 3B 0.0975575
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0870799
ELL2 elongation factor, RNA polymerase II, 2 0.0805269
TF transferrin 0.0645671
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0576907
AFDN afadin, adherens junction formation factor 0.0517692
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0499717
LRMDA leucine rich melanocyte differentiation associated 0.0445962
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0445627
RBM39 RNA binding motif protein 39 0.0430293
ARHGAP9 Rho GTPase activating protein 9 0.0393032
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0392057
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.039133
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0361607
JMJD1C jumonji domain containing 1C 0.0338433
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338391
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0336879
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0319294
DSPP dentin sialophosphoprotein 0.0314144
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0312751
BIRC6 baculoviral IAP repeat containing 6 0.0312313
DOCK4 dedicator of cytokinesis 4 0.0310711
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0308223
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0307242
EML4 echinoderm microtubule associated protein like 4 0.0306588
DENND4A DENN/MADD domain containing 4A 0.0301481
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0299184
SVIL supervillin 0.0299046
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0293985
YAP1 Yes-associated protein 1 0.0291163
RB1CC1 RB1-inducible coiled-coil 1 0.0286715
KDM3A lysine (K)-specific demethylase 3A 0.0285391
ABTB3 ankyrin repeat and BTB domain containing 3 0.0279944
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0277498
ZNF292 zinc finger protein 292 0.0272113
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0270707
SESTD1 SEC14 and spectrin domains 1 0.0269737
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0264079
KDM1A lysine (K)-specific demethylase 1A 0.0262534
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0256038
NCKAP1 NCK-associated protein 1 0.0250348
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0249203
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0245418
KIF5B kinesin family member 5B 0.0240776
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0240078
CRLS1 cardiolipin synthase 1 0.023996
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0238702
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0236921
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0234633
FCHSD2 FCH and double SH3 domains 2 0.0228712
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0227406
SPAG9 sperm associated antigen 9 0.0225846
TM9SF3 transmembrane 9 superfamily member 3 0.02201
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0219972
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0217927
SOS1 son of sevenless homolog 1 (Drosophila) 0.0214686
TRIM26 tripartite motif containing 26 0.0213814
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213802
MBNL3 muscleblind-like splicing regulator 3 0.0210501
KDM7A lysine (K)-specific demethylase 7A 0.020916
USP47 ubiquitin specific peptidase 47 0.020662
ITGB5 integrin, beta 5 0.0205848
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.02057
JAK1 Janus kinase 1 0.0205416
ZMYND8 zinc finger, MYND-type containing 8 0.0204425
MED13L mediator complex subunit 13-like 0.0201648
ZEB1 zinc finger E-box binding homeobox 1 0.0200864
SETD2 SET domain containing 2 0.0200125
INSIG2 insulin induced gene 2 0.0199397
MED13 mediator complex subunit 13 0.0196039
PHF3 PHD finger protein 3 0.0194426
ATP13A3 ATPase type 13A3 0.0194058
YME1L1 YME1-like 1 ATPase 0.0192646
IGF1R insulin-like growth factor 1 receptor 0.0190236
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0188924
FN1 fibronectin 1 0.018763
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0187454
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0187292
BBX bobby sox homolog (Drosophila) 0.0186972
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0186137
NRIP1 nuclear receptor interacting protein 1 0.0185868
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0185575
MRTFA myocardin related transcription factor A 0.0183727
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0182364
PTK2 protein tyrosine kinase 2 0.018201
CDK19 cyclin-dependent kinase 19 0.0181079
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0180987
RLF rearranged L-myc fusion 0.0180615
ADAM10 ADAM metallopeptidase domain 10 0.0180585
VEGFA vascular endothelial growth factor A 0.0180506
NIPBL Nipped-B homolog (Drosophila) 0.0179509
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0179345
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0179126
MALT1 MALT1 paracaspase 0.0178793
LRRC1 leucine rich repeat containing 1 0.0178684
UBQLN1 ubiquilin 1 0.017766
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0177527

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.48858
MT2A metallothionein 2A -0.199801
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.166601
RPL37A ribosomal protein L37a -0.103934
RPS6 ribosomal protein S6 -0.0944493
TPT1 tumor protein, translationally-controlled 1 -0.0890297
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.084405
RPS19 ribosomal protein S19 -0.084332
RPS12 ribosomal protein S12 -0.0815325
RPS8 ribosomal protein S8 -0.0760174
FTL ferritin, light polypeptide -0.0702698
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0680761
RPL35A ribosomal protein L35a -0.0642054
RPLP1 ribosomal protein, large, P1 -0.0569516
IGFBP1 insulin-like growth factor binding protein 1 -0.0558336
AKAP12 A kinase (PRKA) anchor protein 12 -0.0556446
TMSB10 thymosin beta 10 -0.0553253
RPLP2 ribosomal protein, large, P2 -0.052667
RPS3 ribosomal protein S3 -0.0525633
C3 complement component 3 -0.0524524
AHSG alpha-2-HS-glycoprotein -0.0493594
RPL26 ribosomal protein L26 -0.047699
RACK1 receptor for activated C kinase 1 -0.0476638
PDLIM5 PDZ and LIM domain 5 -0.0449984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0447844
RPS27A ribosomal protein S27a -0.0443158
RPL11 ribosomal protein L11 -0.0436441
RPL12 ribosomal protein L12 -0.0430029
APOA2 apolipoprotein A-II -0.0414931
HMGA1 high mobility group AT-hook 1 -0.0411353
RPL23 ribosomal protein L23 -0.0404648
RPS13 ribosomal protein S13 -0.0402464
RPL9 ribosomal protein L9 -0.038611
RPS14 ribosomal protein S14 -0.0377874
INTS6 integrator complex subunit 6 -0.0377705
RPS24 ribosomal protein S24 -0.0362654
RPL31 ribosomal protein L31 -0.0355364
RPL37 ribosomal protein L37 -0.0349091
RPL5 ribosomal protein L5 -0.034537
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0326233
GNAS GNAS complex locus -0.0320223
RPL34 ribosomal protein L34 -0.0315003
GPC6 glypican 6 -0.0312806
VCL vinculin -0.0312435
RPL27 ribosomal protein L27 -0.0309149
RPS29 ribosomal protein S29 -0.030526
ACTG1 actin gamma 1 -0.0305096
RPL19 ribosomal protein L19 -0.0294477
RPS21 ribosomal protein S21 -0.0276849
RPS17 ribosomal protein S17 -0.0273183
NDRG1 N-myc downstream regulated 1 -0.0269996
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0265621
RPS27 ribosomal protein S27 -0.0263628
RPL18 ribosomal protein L18 -0.0255588
RPL36 ribosomal protein L36 -0.0253097
RPL36A ribosomal protein L36a -0.0246649
RPS10 ribosomal protein S10 -0.024485
S100A9 S100 calcium binding protein A9 -0.0244492
RPL28 ribosomal protein L28 -0.0243475
PTMA prothymosin, alpha -0.0242444
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0240816
ASPH aspartate beta-hydroxylase -0.0237692
HM13 histocompatibility (minor) 13 -0.0235905
APOA1 apolipoprotein A-I -0.0233041
APOE apolipoprotein E -0.0229741
AMBP alpha-1-microglobulin/bikunin precursor -0.0229341
B2M beta-2-microglobulin -0.0228673
RPLP0 ribosomal protein, large, P0 -0.0219513
GPC3 glypican 3 -0.0217522
CST3 cystatin C -0.0215936
RPS16 ribosomal protein S16 -0.0213978
RPS25 ribosomal protein S25 -0.0212683
RPL30 ribosomal protein L30 -0.0211256
GK glycerol kinase -0.0210292
DDIT4 DNA-damage-inducible transcript 4 -0.0207569
NABP1 nucleic acid binding protein 1 -0.0203572
GMDS GDP-mannose 4,6-dehydratase -0.0203157
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0199053
APOC1 apolipoprotein C-I -0.019585
RPS4X ribosomal protein S4, X-linked -0.0194211
NPAS2 neuronal PAS domain protein 2 -0.0193886
NAP1L1 nucleosome assembly protein 1-like 1 -0.019192
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0190232
LOC112694756 uncharaterized LOC112694756 -0.0189978
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0189623
KIF21A kinesin family member 21A -0.0189596
RPS23 ribosomal protein S23 -0.0187905
FAM107B family with sequence similarity 107, member B -0.0186865
RPL32 ribosomal protein L32 -0.018649
RPL38 ribosomal protein L38 -0.0185756
RPL10A ribosomal protein L10a -0.0184505
RPS5 ribosomal protein S5 -0.0179777
EXT1 exostosin glycosyltransferase 1 -0.0179766
MAP1B microtubule-associated protein 1B -0.0178916
RPS11 ribosomal protein S11 -0.0178799
UGDH UDP-glucose 6-dehydrogenase -0.0177585
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0176272
H1-0 H1.0 linker histone -0.0174924
RPL7 ribosomal protein L7 -0.0174605
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0174445