Bosentan (hydrate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0705914
MEF2A myocyte enhancer factor 2A 0.0628071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0337071
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0335417
OGA O-GlcNAcase 0.0333137
CANX calnexin 0.0325955
ITCH itchy E3 ubiquitin protein ligase 0.0324018
KDM6A lysine (K)-specific demethylase 6A 0.0322251
SQLE squalene epoxidase 0.0314351
RBM39 RNA binding motif protein 39 0.0289692
MTSS1 metastasis suppressor 1 0.0286541
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282743
ESYT2 extended synaptotagmin-like protein 2 0.0269682
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0268682
KDM3A lysine (K)-specific demethylase 3A 0.025645
SUCO SUN domain containing ossification factor 0.0241208
RAI14 retinoic acid induced 14 0.0224772
NAV2 neuron navigator 2 0.0220551
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0213971
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0212901
CDC73 cell division cycle 73 0.0206308
GRB10 growth factor receptor-bound protein 10 0.0202768
SPAG9 sperm associated antigen 9 0.0200736
RICTOR RPTOR independent companion of MTOR, complex 2 0.0197781
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0189489
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0188684
DLG1 discs, large homolog 1 (Drosophila) 0.0188507
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.018742
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0186489
FNIP1 folliculin interacting protein 1 0.0185721
NAMPT nicotinamide phosphoribosyltransferase 0.0185097
BZW1 basic leucine zipper and W2 domains 1 0.0183124
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.017373
KRT6A keratin 6A, type II 0.017333
SLMAP sarcolemma associated protein 0.0172115
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0170408
PRELID2 PRELI domain containing 2 0.0169305
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0166477
ZFC3H1 zinc finger, C3H1-type containing 0.0166039
ANXA1 annexin A1 0.0162917
KMT2C lysine (K)-specific methyltransferase 2C 0.0161012
HELZ helicase with zinc finger 0.0156011
MARCHF6 membrane associated ring-CH-type finger 6 0.0155417
NRIP1 nuclear receptor interacting protein 1 0.0154587
GOLGA4 golgin A4 0.0154524
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0152962
COG6 component of oligomeric golgi complex 6 0.0152377
TFG TRK-fused gene 0.0151323
TRA2A transformer 2 alpha homolog (Drosophila) 0.0150978
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.014545
PTK2 protein tyrosine kinase 2 0.0143946
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0141604
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0138967
TMEM39A transmembrane protein 39A 0.013833
PSD3 pleckstrin and Sec7 domain containing 3 0.0137691
BIRC2 baculoviral IAP repeat containing 2 0.0136806
KDM1A lysine (K)-specific demethylase 1A 0.0136601
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136225
PICALM phosphatidylinositol binding clathrin assembly protein 0.0135454
FAR1 fatty acyl CoA reductase 1 0.0135086
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0134815
FAM13A family with sequence similarity 13, member A 0.0134806
NUP58 nucleoporin 58 0.0134493
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.013419
NCKAP1 NCK-associated protein 1 0.0132517
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.013169
NAP1L1 nucleosome assembly protein 1-like 1 0.0129798
ATP13A3 ATPase type 13A3 0.0129628
QKI QKI, KH domain containing, RNA binding 0.0127935
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0127318
SQSTM1 sequestosome 1 0.0125149
SEC63 SEC63 homolog (S. cerevisiae) 0.0124815
SLC35F3 solute carrier family 35, member F3 0.0123201
PDIA3 protein disulfide isomerase family A, member 3 0.0123112
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0122946
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0121976
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0121772
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0121629
SKIC3 SKI3 subunit of superkiller complex 0.0119382
CYLD cylindromatosis (turban tumor syndrome) 0.0118166
ZMYM2 zinc finger, MYM-type 2 0.0118123
USP9X ubiquitin specific peptidase 9, X-linked 0.0118114
TMEM65 transmembrane protein 65 0.0117735
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0117655
ARHGAP12 Rho GTPase activating protein 12 0.0117374
USP3 ubiquitin specific peptidase 3 0.0117238
TMF1 TATA element modulatory factor 1 0.0116464
RNF145 ring finger protein 145 0.0114749
AKAP13 A kinase (PRKA) anchor protein 13 0.0113326
KIAA1217 KIAA1217 0.0113245
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0112807
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0112526
SAR1A secretion associated, Ras related GTPase 1A 0.0111735
SMG7 SMG7 nonsense mediated mRNA decay factor 0.011141
ABI3BP ABI family, member 3 (NESH) binding protein 0.0111217
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0111146
SENP6 SUMO1/sentrin specific peptidase 6 0.010965
DIDO1 death inducer-obliterator 1 0.0109477
ELL2 elongation factor, RNA polymerase II, 2 0.0109417
YME1L1 YME1-like 1 ATPase 0.010841

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.247065
NDRG1 N-myc downstream regulated 1 -0.166297
MT2A metallothionein 2A -0.133227
TMSB10 thymosin beta 10 -0.100536
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0841696
B2M beta-2-microglobulin -0.082798
IFITM3 interferon induced transmembrane protein 3 -0.0721478
POTEF POTE ankyrin domain family, member F -0.0719735
IFITM1 interferon induced transmembrane protein 1 -0.0718102
RPS6 ribosomal protein S6 -0.0690758
HLA-B major histocompatibility complex, class I, B -0.0602311
IGF2 insulin-like growth factor 2 -0.0600881
S100A10 S100 calcium binding protein A10 -0.0598035
LOC112694756 uncharaterized LOC112694756 -0.0593905
RPS21 ribosomal protein S21 -0.0565994
RPLP2 ribosomal protein, large, P2 -0.0547747
CD44 CD44 molecule (Indian blood group) -0.053163
RPS19 ribosomal protein S19 -0.0526132
GNAS GNAS complex locus -0.0523723
RPLP1 ribosomal protein, large, P1 -0.0522646
CYB5R3 cytochrome b5 reductase 3 -0.049969
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0498388
BCL2L1 BCL2-like 1 -0.0483717
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0479221
PLAT plasminogen activator, tissue -0.0467036
PKM pyruvate kinase, muscle -0.0448779
OSMR oncostatin M receptor -0.0447583
CLU clusterin -0.0446901
RPL8 ribosomal protein L8 -0.0442429
RPS13 ribosomal protein S13 -0.0427946
RPL11 ribosomal protein L11 -0.0411962
TGM2 transglutaminase 2 -0.0406282
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0403689
IGFBP4 insulin-like growth factor binding protein 4 -0.0402069
IFI6 interferon, alpha-inducible protein 6 -0.0400723
FTL ferritin, light polypeptide -0.0387004
ACTN4 actinin, alpha 4 -0.038525
LDHA lactate dehydrogenase A -0.0377324
RPS8 ribosomal protein S8 -0.0373459
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0361715
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0359836
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0354043
FOXP1 forkhead box P1 -0.0353771
LAMA5 laminin, alpha 5 -0.0346729
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0343039
ENO1 enolase 1, (alpha) -0.0339592
RPS23 ribosomal protein S23 -0.0334856
FTH1 ferritin, heavy polypeptide 1 -0.0334228
CMIP c-Maf inducing protein -0.033161
TPT1 tumor protein, translationally-controlled 1 -0.0323893
RPL35A ribosomal protein L35a -0.0321114
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0319679
RPL32 ribosomal protein L32 -0.0317531
RPL37 ribosomal protein L37 -0.0317388
HSPG2 heparan sulfate proteoglycan 2 -0.0316659
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0316556
WASF2 WAS protein family, member 2 -0.031644
S100A9 S100 calcium binding protein A9 -0.0313294
S100A6 S100 calcium binding protein A6 -0.0310928
S100A11 S100 calcium binding protein A11 -0.0307013
ITGB4 integrin, beta 4 -0.030207
RPL12 ribosomal protein L12 -0.0295114
LMNA lamin A/C -0.0294445
EPHA2 EPH receptor A2 -0.0291119
RPL36 ribosomal protein L36 -0.0284444
ITGA6 integrin, alpha 6 -0.0284245
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0282502
CNRIP1 cannabinoid receptor interacting protein 1 -0.028214
MDK midkine (neurite growth-promoting factor 2) -0.0280679
RPL19 ribosomal protein L19 -0.0276383
YBX3 Y box binding protein 3 -0.0273131
EGR1 early growth response 1 -0.0270817
RPL7A ribosomal protein L7a -0.027078
TNS4 tensin 4 -0.0270728
S100A2 S100 calcium binding protein A2 -0.0268141
ZNFX1 zinc finger, NFX1-type containing 1 -0.0264848
MBNL1 muscleblind-like splicing regulator 1 -0.0263918
CD99 CD99 molecule -0.0262292
ACTG1 actin gamma 1 -0.0260915
MT1X metallothionein 1X -0.0260909
SULF2 sulfatase 2 -0.0260239
RPS29 ribosomal protein S29 -0.0259307
H1-0 H1.0 linker histone -0.0257506
IFI27 interferon, alpha-inducible protein 27 -0.0256297
RPL30 ribosomal protein L30 -0.0254178
MRPS6 mitochondrial ribosomal protein S6 -0.025398
PFN1 profilin 1 -0.0250117
RPS15 ribosomal protein S15 -0.0247404
RPL28 ribosomal protein L28 -0.024709
MYOF myoferlin -0.0245765
FLNB filamin B, beta -0.024412
GUK1 guanylate kinase 1 -0.0243362
TXNIP thioredoxin interacting protein -0.0241751
RPL35 ribosomal protein L35 -0.0239345
ZMYND8 zinc finger, MYND-type containing 8 -0.0239186
RPL9 ribosomal protein L9 -0.023824
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0235579
RPS27 ribosomal protein S27 -0.0232974
CST3 cystatin C -0.0232907
FOSL1 FOS-like antigen 1 -0.0231322