Bosentan (hydrate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110563
AKAP12 A kinase (PRKA) anchor protein 12 0.103763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0772074
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0769158
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0705618
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0691739
DTNA dystrobrevin, alpha 0.0649501
PTMA prothymosin, alpha 0.0578934
TPT1 tumor protein, translationally-controlled 1 0.0544696
ZNF841 zinc finger protein 841 0.05434
VIM vimentin 0.0531476
NAV2 neuron navigator 2 0.0526032
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0493762
CANX calnexin 0.0460729
ERRFI1 ERBB receptor feedback inhibitor 1 0.0451292
CXCL8 chemokine (C-X-C motif) ligand 8 0.0450937
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0444711
RPL35A ribosomal protein L35a 0.0438048
ATP13A3 ATPase type 13A3 0.0435975
RPS6 ribosomal protein S6 0.0425272
ENO1 enolase 1, (alpha) 0.0422775
RPL23 ribosomal protein L23 0.0412805
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0409135
BZW1 basic leucine zipper and W2 domains 1 0.0392678
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0384411
PHACTR1 phosphatase and actin regulator 1 0.0361415
PLIN2 perilipin 2 0.0352998
SET SET nuclear proto-oncogene 0.0352124
NAP1L1 nucleosome assembly protein 1-like 1 0.0347474
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0347442
BHLHE40 basic helix-loop-helix family, member e40 0.0328379
RND3 Rho family GTPase 3 0.0328087
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321015
RPL12 ribosomal protein L12 0.0303825
RPS8 ribosomal protein S8 0.0300157
FGFR1 fibroblast growth factor receptor 1 0.0299728
ASPH aspartate beta-hydroxylase 0.0295895
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0294569
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.02922
HMGB2 high mobility group box 2 0.0291006
NUP58 nucleoporin 58 0.028822
RPS3 ribosomal protein S3 0.0287342
BTG1 B-cell translocation gene 1, anti-proliferative 0.0286255
OGA O-GlcNAcase 0.0269752
ARRDC3 arrestin domain containing 3 0.0269553
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0263855
RPL26 ribosomal protein L26 0.0257183
FAM162A family with sequence similarity 162, member A 0.0257023
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0255709
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0252242
ZFP36L1 ZFP36 ring finger protein-like 1 0.0248784
RPL37A ribosomal protein L37a 0.0245858
RPS12 ribosomal protein S12 0.0242415
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0238438
MXI1 MAX interactor 1, dimerization protein 0.0237495
TFRC transferrin receptor 0.0236403
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0232759
PRELID2 PRELI domain containing 2 0.0231471
PHF3 PHD finger protein 3 0.0230495
INSIG2 insulin induced gene 2 0.0229074
TPM3 tropomyosin 3 0.0224125
SQSTM1 sequestosome 1 0.0223812
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0219215
DIPK2A divergent protein kinase domain 2A 0.0217394
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0214928
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0214583
RIOK3 RIO kinase 3 0.0211748
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0209907
FAM107B family with sequence similarity 107, member B 0.0209331
MYO10 myosin X 0.0208801
SRSF4 serine/arginine-rich splicing factor 4 0.0203942
LDHA lactate dehydrogenase A 0.0203718
CADM1 cell adhesion molecule 1 0.0202299
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0201274
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0196303
RPS17 ribosomal protein S17 0.0194823
RPL35 ribosomal protein L35 0.0194135
RACK1 receptor for activated C kinase 1 0.0193488
ZNF292 zinc finger protein 292 0.0193465
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0191596
IRS2 insulin receptor substrate 2 0.0190663
RPS27A ribosomal protein S27a 0.0190562
RNMT RNA (guanine-7-) methyltransferase 0.0189693
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0189041
RPL11 ribosomal protein L11 0.0188133
CREBRF CREB3 regulatory factor 0.0186893
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0185972
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0183701
WTAP Wilms tumor 1 associated protein 0.0181754
VEGFA vascular endothelial growth factor A 0.018157
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0178859
RPL7 ribosomal protein L7 0.0178483
RPL21 ribosomal protein L21 0.0177347
ANKRD12 ankyrin repeat domain 12 0.0176467
SPAG9 sperm associated antigen 9 0.0174898
RPLP2 ribosomal protein, large, P2 0.0174229
JUN jun proto-oncogene 0.017188
KIF5B kinesin family member 5B 0.0171011
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0170688
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0168787

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.222144
HLA-B major histocompatibility complex, class I, B -0.169111
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14791
NALF1 NALCN channel auxiliary factor 1 -0.135481
GLIS3 GLIS family zinc finger 3 -0.127496
FN1 fibronectin 1 -0.125988
MT1X metallothionein 1X -0.101779
TXNRD1 thioredoxin reductase 1 -0.0992046
SLC12A8 solute carrier family 12, member 8 -0.0979054
EXT1 exostosin glycosyltransferase 1 -0.0964128
ARF4 ADP-ribosylation factor 4 -0.083358
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0764766
PLCB4 phospholipase C, beta 4 -0.075107
ABI3BP ABI family, member 3 (NESH) binding protein -0.0737438
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0699988
HEG1 heart development protein with EGF-like domains 1 -0.064383
COL5A1 collagen, type V, alpha 1 -0.0635705
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.062181
FLNB filamin B, beta -0.0563289
MT2A metallothionein 2A -0.0561473
SAMD12 sterile alpha motif domain containing 12 -0.0542308
OSMR oncostatin M receptor -0.0512041
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0510521
POSTN periostin, osteoblast specific factor -0.0499247
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0498287
TMEM178B transmembrane protein 178B -0.0497162
ERBIN erbb2 interacting protein -0.049338
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0491781
DLG1 discs, large homolog 1 (Drosophila) -0.0485882
TGFB2 transforming growth factor, beta 2 -0.0482023
MAP1B microtubule-associated protein 1B -0.0456824
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0455152
DEK DEK proto-oncogene -0.0449281
FTH1 ferritin, heavy polypeptide 1 -0.0443664
CTSD cathepsin D -0.0434842
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0422255
SULF1 sulfatase 1 -0.0418704
PRRC2B proline-rich coiled-coil 2B -0.0416797
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0399926
FOXP1 forkhead box P1 -0.0399763
F3 coagulation factor III (thromboplastin, tissue factor) -0.0398603
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0395028
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0392139
DIAPH3 diaphanous-related formin 3 -0.0391386
CCBE1 collagen and calcium binding EGF domains 1 -0.0377257
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0372262
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0368104
ZNF804A zinc finger protein 804A -0.0367251
CALU calumenin -0.0365419
GRAMD2B GRAM domain containing 2B -0.0361928
STAU1 staufen double-stranded RNA binding protein 1 -0.03605
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0359309
PARD3B par-3 family cell polarity regulator beta -0.0359298
EGR1 early growth response 1 -0.035586
ZBTB20 zinc finger and BTB domain containing 20 -0.0345081
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0342243
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0335681
VEGFC vascular endothelial growth factor C -0.0335673
FLNA filamin A, alpha -0.0334391
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0333248
FSTL1 follistatin-like 1 -0.0333103
CD44 CD44 molecule (Indian blood group) -0.0332389
PTPRG protein tyrosine phosphatase, receptor type, G -0.0330429
LOC112694756 uncharaterized LOC112694756 -0.0328839
SLIT2 slit homolog 2 (Drosophila) -0.0328384
TENM3 teneurin transmembrane protein 3 -0.032153
ITCH itchy E3 ubiquitin protein ligase -0.0319446
KPNB1 karyopherin (importin) beta 1 -0.0316185
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0310504
COPA coatomer protein complex, subunit alpha -0.0309155
PRUNE2 prune homolog 2 (Drosophila) -0.0307937
COPB1 coatomer protein complex, subunit beta 1 -0.0296331
DPYD dihydropyrimidine dehydrogenase -0.0295531
LYPD6B LY6/PLAUR domain containing 6B -0.0295042
LIMCH1 LIM and calponin homology domains 1 -0.0290853
NPPB natriuretic peptide B -0.0289162
SEC16A SEC16 homolog A (S. cerevisiae) -0.0283194
RHOBTB3 Rho-related BTB domain containing 3 -0.028261
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0277544
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0274516
C6ORF62 chromosome 6 open reading frame 62 -0.0274099
NRG1 neuregulin 1 -0.0271355
GOLGB1 golgin B1 -0.0270821
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0269774
TPM1 tropomyosin 1 (alpha) -0.026762
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0265584
GSK3B glycogen synthase kinase 3 beta -0.0265459
ZNFX1 zinc finger, NFX1-type containing 1 -0.0265372
PPME1 protein phosphatase methylesterase 1 -0.026206
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.026148
FOSL1 FOS-like antigen 1 -0.026134
IARS1 isoleucyl-tRNA synthetase 1 -0.0260682
NF1 neurofibromin 1 -0.025765
BMPER BMP binding endothelial regulator -0.0256815
ZXDC ZXD family zinc finger C -0.0256003
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0254471
RAI14 retinoic acid induced 14 -0.0249456
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.024904
PTBP3 polypyrimidine tract binding protein 3 -0.024798
CLTC clathrin, heavy chain (Hc) -0.0247498