Bosentan (hydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0422447
NUP58 nucleoporin 58 0.0400298
ATP13A3 ATPase type 13A3 0.0349306
KDM3A lysine (K)-specific demethylase 3A 0.0332926
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0280072
ELL2 elongation factor, RNA polymerase II, 2 0.0274428
ADAM9 ADAM metallopeptidase domain 9 0.0266752
NAMPT nicotinamide phosphoribosyltransferase 0.0264231
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.025603
RNF145 ring finger protein 145 0.0238649
WDR43 WD repeat domain 43 0.0234828
UGCG UDP-glucose ceramide glucosyltransferase 0.0233943
NCKAP1 NCK-associated protein 1 0.0226807
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0222669
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0210588
USP3 ubiquitin specific peptidase 3 0.0206531
RAD21 RAD21 homolog (S. pombe) 0.0199667
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0197583
ERRFI1 ERBB receptor feedback inhibitor 1 0.0196676
SPAG9 sperm associated antigen 9 0.0194871
RLF rearranged L-myc fusion 0.0193405
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0189205
CDC73 cell division cycle 73 0.0188387
TSC22D2 TSC22 domain family, member 2 0.0185605
RBM39 RNA binding motif protein 39 0.0185376
CDK17 cyclin-dependent kinase 17 0.0182141
BCLAF1 BCL2-associated transcription factor 1 0.017793
TRA2A transformer 2 alpha homolog (Drosophila) 0.0177305
RAB8B RAB8B, member RAS oncogene family 0.0177031
PUM2 pumilio RNA-binding family member 2 0.0175813
AKAP12 A kinase (PRKA) anchor protein 12 0.017494
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0170783
ABI1 abl-interactor 1 0.0170414
QKI QKI, KH domain containing, RNA binding 0.0163847
OGA O-GlcNAcase 0.0162846
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0162679
HELZ helicase with zinc finger 0.0160854
RB1CC1 RB1-inducible coiled-coil 1 0.0159731
MARCHF6 membrane associated ring-CH-type finger 6 0.0158967
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0158045
FNBP1L formin binding protein 1-like 0.0157416
MXI1 MAX interactor 1, dimerization protein 0.0156414
CCNL1 cyclin L1 0.0156402
RAD23B RAD23 homolog B (S. cerevisiae) 0.0151142
TFG TRK-fused gene 0.015011
CD109 CD109 molecule 0.0145333
CHD1 chromodomain helicase DNA binding protein 1 0.0144726
NEK7 NIMA-related kinase 7 0.0143917
WDR45B WD repeat domain 45B 0.0140079
WAC WW domain containing adaptor with coiled-coil 0.0137895
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0137017
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0135921
MEF2A myocyte enhancer factor 2A 0.0134073
CASC3 cancer susceptibility candidate 3 0.0132827
CEP170 centrosomal protein 170kDa 0.0132127
PNISR PNN-interacting serine/arginine-rich protein 0.0131951
KMT2E lysine (K)-specific methyltransferase 2E 0.0131609
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0130596
ETNK1 ethanolamine kinase 1 0.0129531
UBQLN1 ubiquilin 1 0.0128267
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0127247
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0127064
HAS2 hyaluronan synthase 2 0.012405
FOXJ3 forkhead box J3 0.0122876
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.012276
RICTOR RPTOR independent companion of MTOR, complex 2 0.0122588
SERINC1 serine incorporator 1 0.0122317
KLF6 Kruppel-like factor 6 0.0119642
WSB1 WD repeat and SOCS box containing 1 0.0118351
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0118274
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0117716
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0117244
TEX10 testis expressed 10 0.0117115
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0115904
TFRC transferrin receptor 0.011526
TRIM33 tripartite motif containing 33 0.0114539
FUBP1 far upstream element (FUSE) binding protein 1 0.0114082
MIMS1 mitochondrial inner membrane scaffold 1 0.0113077
NUP153 nucleoporin 153kDa 0.0111825
HDAC3 histone deacetylase 3 0.0111337
AZIN1 antizyme inhibitor 1 0.0110696
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0109315
LCORL ligand dependent nuclear receptor corepressor-like 0.0109075
ARGLU1 arginine and glutamate rich 1 0.0108616
PRKCI protein kinase C, iota 0.010731
SIK3 SIK family kinase 3 0.0106958
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0106155
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0104904
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0104531
RBM27 RNA binding motif protein 27 0.0103705
BZW1 basic leucine zipper and W2 domains 1 0.0103445
CCDC50 coiled-coil domain containing 50 0.0103359
BRWD3 bromodomain and WD repeat domain containing 3 0.010233
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0101699
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0101433
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0101366
KMT2C lysine (K)-specific methyltransferase 2C 0.0100842
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0100786
ZFAND3 zinc finger, AN1-type domain 3 0.0100156
PRPF4B pre-mRNA processing factor 4B 0.0098117

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.39647
VIM vimentin -0.20608
EXT1 exostosin glycosyltransferase 1 -0.137209
DTNA dystrobrevin, alpha -0.116103
EFNA5 ephrin-A5 -0.115773
PRKG1 protein kinase, cGMP-dependent, type I -0.0945171
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0924106
ASPH aspartate beta-hydroxylase -0.0876131
PKM pyruvate kinase, muscle -0.0863399
TMSB10 thymosin beta 10 -0.0836901
ACTG1 actin gamma 1 -0.0826049
PTPRG protein tyrosine phosphatase, receptor type, G -0.0791479
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.07326
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0717498
PHACTR1 phosphatase and actin regulator 1 -0.0716231
EEF2 eukaryotic translation elongation factor 2 -0.0697854
FTL ferritin, light polypeptide -0.0695198
RPS6 ribosomal protein S6 -0.0680133
RPS27A ribosomal protein S27a -0.0661727
RUNX1 runt-related transcription factor 1 -0.0627
HDAC9 histone deacetylase 9 -0.0614998
SAMD3 sterile alpha motif domain containing 3 -0.0605177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0585318
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0555237
CDH13 cadherin 13 -0.0535963
NAV1 neuron navigator 1 -0.0532871
SAMD4A sterile alpha motif domain containing 4A -0.0531871
KIAA1549L KIAA1549-like -0.051972
KIAA1217 KIAA1217 -0.0516367
MT2A metallothionein 2A -0.0510407
RPL23 ribosomal protein L23 -0.0508241
PRKCE protein kinase C, epsilon -0.0499017
UBC ubiquitin C -0.0490639
RPS8 ribosomal protein S8 -0.0484089
INTS6 integrator complex subunit 6 -0.0474275
RPS3 ribosomal protein S3 -0.0469275
SDCCAG8 serologically defined colon cancer antigen 8 -0.0462528
NDRG1 N-myc downstream regulated 1 -0.0457721
LDHA lactate dehydrogenase A -0.0457452
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0452818
AHNAK AHNAK nucleoprotein -0.0452401
NABP1 nucleic acid binding protein 1 -0.0442163
USP34 ubiquitin specific peptidase 34 -0.0432788
DSCAM Down syndrome cell adhesion molecule -0.0422596
CDK6 cyclin-dependent kinase 6 -0.0417446
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0406123
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0399655
NALF1 NALCN channel auxiliary factor 1 -0.0391849
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0391773
HMGA2 high mobility group AT-hook 2 -0.0382663
HMGA1 high mobility group AT-hook 1 -0.0380776
LOC112694756 uncharaterized LOC112694756 -0.0379866
EGR1 early growth response 1 -0.0379241
PTPRD protein tyrosine phosphatase, receptor type, D -0.0377117
PBX3 pre-B-cell leukemia homeobox 3 -0.0372621
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0372351
RPS12 ribosomal protein S12 -0.0370523
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.036963
MARCHF4 membrane associated ring-CH-type finger 4 -0.03656
LSAMP limbic system-associated membrane protein -0.036033
RPL5 ribosomal protein L5 -0.0360328
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0358991
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0354869
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0349887
RPL37A ribosomal protein L37a -0.0348034
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347591
ENO1 enolase 1, (alpha) -0.0344953
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0343527
FLNA filamin A, alpha -0.0341433
RPL31 ribosomal protein L31 -0.0341167
LIMCH1 LIM and calponin homology domains 1 -0.033513
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0334649
RPL35A ribosomal protein L35a -0.0333166
RPLP1 ribosomal protein, large, P1 -0.0329393
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0324746
CALD1 caldesmon 1 -0.0323924
RPL12 ribosomal protein L12 -0.0322912
BPTF bromodomain PHD finger transcription factor -0.0322293
MSR1 macrophage scavenger receptor 1 -0.0320702
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0316454
MYO10 myosin X -0.0315912
NAV3 neuron navigator 3 -0.0313507
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0312142
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0309174
RACK1 receptor for activated C kinase 1 -0.0307998
RPS13 ribosomal protein S13 -0.0305291
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0304221
NAP1L1 nucleosome assembly protein 1-like 1 -0.029907
AEBP2 AE binding protein 2 -0.0298572
ZNF804A zinc finger protein 804A -0.0297246
PCBP2 poly(rC) binding protein 2 -0.0296157
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0295698
ADAM32 ADAM metallopeptidase domain 32 -0.0288778
POTEF POTE ankyrin domain family, member F -0.0284934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.028479
RPS19 ribosomal protein S19 -0.0282047
GPC6 glypican 6 -0.0279176
NCOR2 nuclear receptor corepressor 2 -0.027562
KDM4C lysine (K)-specific demethylase 4C -0.0274908
RPS17 ribosomal protein S17 -0.0274272