| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.164913 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.118487 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.116594 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0847034 |
| FAM13A | family with sequence similarity 13, member A | 0.0663635 |
| PTMA | prothymosin, alpha | 0.0596226 |
| PRELID2 | PRELI domain containing 2 | 0.0521429 |
| CCNY | cyclin Y | 0.0482806 |
| MED13L | mediator complex subunit 13-like | 0.0443442 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0421871 |
| ENO1 | enolase 1, (alpha) | 0.0405458 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0399545 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0384783 |
| EREG | epiregulin | 0.0372494 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0357903 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0345881 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0344529 |
| RBM39 | RNA binding motif protein 39 | 0.0343342 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0321998 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0320594 |
| RNF145 | ring finger protein 145 | 0.0311969 |
| ZNF292 | zinc finger protein 292 | 0.0303598 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.029518 |
| DSPP | dentin sialophosphoprotein | 0.0290903 |
| AHNAK | AHNAK nucleoprotein | 0.0290343 |
| CALR | calreticulin | 0.0285451 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0282916 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0277456 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0259664 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.025905 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0256316 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0252022 |
| RLF | rearranged L-myc fusion | 0.0249936 |
| TFG | TRK-fused gene | 0.0249893 |
| CD2AP | CD2-associated protein | 0.0247688 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0244563 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0241385 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0239395 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0238407 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0238391 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0237843 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0235037 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.023017 |
| FNBP1L | formin binding protein 1-like | 0.0229831 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0229764 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0229313 |
| CENPF | centromere protein F, 350/400kDa | 0.0229198 |
| YTHDC1 | YTH domain containing 1 | 0.0228647 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0226815 |
| RPS12 | ribosomal protein S12 | 0.0224271 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0222758 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.022185 |
| RIOK3 | RIO kinase 3 | 0.0219607 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0218794 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0217201 |
| PDZD8 | PDZ domain containing 8 | 0.0215393 |
| USP3 | ubiquitin specific peptidase 3 | 0.0214084 |
| PGK1 | phosphoglycerate kinase 1 | 0.0213004 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0212352 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0211142 |
| TFRC | transferrin receptor | 0.0209761 |
| KIF5B | kinesin family member 5B | 0.0207564 |
| TMSB4X | thymosin beta 4, X-linked | 0.0207018 |
| TPD52 | tumor protein D52 | 0.0206872 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0205687 |
| NUP58 | nucleoporin 58 | 0.0203581 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0201031 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0198329 |
| YME1L1 | YME1-like 1 ATPase | 0.0198303 |
| NCKAP1 | NCK-associated protein 1 | 0.0196052 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0195877 |
| HMGB2 | high mobility group box 2 | 0.019485 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0193618 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0193194 |
| CANX | calnexin | 0.0192148 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0191547 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.018674 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0185307 |
| RPL4 | ribosomal protein L4 | 0.0182576 |
| SUCO | SUN domain containing ossification factor | 0.018129 |
| SERINC1 | serine incorporator 1 | 0.0180904 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0180749 |
| HELZ | helicase with zinc finger | 0.0178525 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0177756 |
| LRRC1 | leucine rich repeat containing 1 | 0.0177441 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0176778 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0176206 |
| UBQLN1 | ubiquilin 1 | 0.0176153 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0175554 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0172169 |
| LDHA | lactate dehydrogenase A | 0.0170738 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0170309 |
| AFDN | afadin, adherens junction formation factor | 0.0169097 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0167972 |
| RYBP | RING1 and YY1 binding protein | 0.0165846 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0165368 |
| TES | testin LIM domain protein | 0.016452 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0162813 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0158758 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0158569 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.284789 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.170938 |
| TNS4 | tensin 4 | -0.159091 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.15699 |
| FAT1 | FAT atypical cadherin 1 | -0.135354 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.133803 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.123996 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.113861 |
| ANXA2 | annexin A2 | -0.105637 |
| ITGA6 | integrin, alpha 6 | -0.101436 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0943327 |
| MYO1E | myosin IE | -0.0891417 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0848146 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0834085 |
| ABHD2 | abhydrolase domain containing 2 | -0.0816018 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0781242 |
| CADPS | Ca++-dependent secretion activator | -0.0743282 |
| ACTN4 | actinin, alpha 4 | -0.0719883 |
| RNF43 | ring finger protein 43 | -0.070638 |
| TRIM2 | tripartite motif containing 2 | -0.0663438 |
| PRSS3 | protease, serine, 3 | -0.0662545 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0604085 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0595751 |
| PKM | pyruvate kinase, muscle | -0.0577406 |
| NDRG1 | N-myc downstream regulated 1 | -0.0565757 |
| CALB1 | calbindin 1, 28kDa | -0.05216 |
| TMSB10 | thymosin beta 10 | -0.0519054 |
| LMO7 | LIM domain 7 | -0.0487116 |
| ITGB4 | integrin, beta 4 | -0.0483296 |
| VCL | vinculin | -0.0480371 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0478525 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0469591 |
| GPHN | gephyrin | -0.0453705 |
| EGR1 | early growth response 1 | -0.0453055 |
| HMGA1 | high mobility group AT-hook 1 | -0.0444853 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0422328 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0413699 |
| POTEF | POTE ankyrin domain family, member F | -0.0408074 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0405596 |
| MUC17 | mucin 17, cell surface associated | -0.0403283 |
| FHL2 | four and a half LIM domains 2 | -0.0395424 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0389291 |
| CD44 | CD44 molecule (Indian blood group) | -0.0375088 |
| NOSTRIN | nitric oxide synthase trafficking | -0.0373386 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0372666 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0370833 |
| RAB10 | RAB10, member RAS oncogene family | -0.0364955 |
| BCL2L1 | BCL2-like 1 | -0.036225 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0357305 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0354305 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.03533 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0352607 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.034989 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0349064 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0344375 |
| SEPTIN9 | septin 9 | -0.0344119 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.034388 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0339158 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0335303 |
| SH3D19 | SH3 domain containing 19 | -0.0333146 |
| TMEM45B | transmembrane protein 45B | -0.0332855 |
| POF1B | premature ovarian failure, 1B | -0.032596 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0324055 |
| FOXO1 | forkhead box O1 | -0.0323203 |
| JUP | junction plakoglobin | -0.03147 |
| ACTG1 | actin gamma 1 | -0.0314158 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0310569 |
| WWC1 | WW and C2 domain containing 1 | -0.0308048 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0304624 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0303899 |
| PKP2 | plakophilin 2 | -0.0301655 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0298827 |
| CMIP | c-Maf inducing protein | -0.0295855 |
| VMP1 | vacuole membrane protein 1 | -0.029381 |
| LAMA4 | laminin, alpha 4 | -0.029337 |
| MED13 | mediator complex subunit 13 | -0.0291239 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0288278 |
| WASF2 | WAS protein family, member 2 | -0.028106 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0279342 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0276308 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0276142 |
| CLTC | clathrin, heavy chain (Hc) | -0.0276051 |
| KIAA1217 | KIAA1217 | -0.0275698 |
| JMJD1C | jumonji domain containing 1C | -0.0274623 |
| EPHA2 | EPH receptor A2 | -0.0274138 |
| FOXP1 | forkhead box P1 | -0.027301 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0272244 |
| ARF4 | ADP-ribosylation factor 4 | -0.0271425 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | -0.0270697 |
| BRD2 | bromodomain containing 2 | -0.0269803 |
| EPHB2 | EPH receptor B2 | -0.0268688 |
| FLNB | filamin B, beta | -0.0268154 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0266207 |
| FTL | ferritin, light polypeptide | -0.0266002 |
| FOSL1 | FOS-like antigen 1 | -0.0263336 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0262408 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.026016 |
| MAP4 | microtubule-associated protein 4 | -0.0257595 |
| PFN1 | profilin 1 | -0.0256742 |
| NFIA | nuclear factor I/A | -0.0254302 |
