| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.130395 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.129321 |
| GOLGA4 | golgin A4 | 0.110051 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102919 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0984393 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0964822 |
| PRELID2 | PRELI domain containing 2 | 0.0738572 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0675736 |
| ZNF292 | zinc finger protein 292 | 0.0591255 |
| CANX | calnexin | 0.0542902 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.052097 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0498881 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0457588 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0454201 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0450029 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0415335 |
| PTEN | phosphatase and tensin homolog | 0.0413137 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0411815 |
| CDK19 | cyclin-dependent kinase 19 | 0.0407821 |
| OGA | O-GlcNAcase | 0.0405401 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0401257 |
| MED13L | mediator complex subunit 13-like | 0.0397599 |
| TMF1 | TATA element modulatory factor 1 | 0.039611 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0393366 |
| EREG | epiregulin | 0.0391993 |
| CCPG1 | cell cycle progression 1 | 0.038408 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0376983 |
| NKTR | natural killer cell triggering receptor | 0.03697 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0369314 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0363313 |
| COG5 | component of oligomeric golgi complex 5 | 0.0356143 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0354618 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0354553 |
| USP3 | ubiquitin specific peptidase 3 | 0.0351826 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0347503 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0346152 |
| CDC42SE2 | CDC42 small effector 2 | 0.0338185 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.033787 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0328292 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0325294 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0314868 |
| KIF5B | kinesin family member 5B | 0.0311459 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.030547 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0303846 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0291627 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.02908 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0289053 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0286125 |
| CLINT1 | clathrin interactor 1 | 0.0285759 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0285606 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0279228 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0278046 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0274946 |
| XPO1 | exportin 1 | 0.0272008 |
| BBX | bobby sox homolog (Drosophila) | 0.0271847 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0267504 |
| FAM13A | family with sequence similarity 13, member A | 0.0266654 |
| RNF145 | ring finger protein 145 | 0.0266645 |
| RLF | rearranged L-myc fusion | 0.0265642 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0265085 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0264726 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0260952 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0260532 |
| MYO6 | myosin VI | 0.0259475 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0258656 |
| HELZ | helicase with zinc finger | 0.0255654 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0255152 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0252708 |
| USP34 | ubiquitin specific peptidase 34 | 0.0251058 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0250589 |
| ATXN1 | ataxin 1 | 0.0249576 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.024766 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0246921 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.024481 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0244767 |
| LRRC1 | leucine rich repeat containing 1 | 0.0244533 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0243962 |
| MLEC | malectin | 0.0242551 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.024192 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0241613 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0241561 |
| SUCO | SUN domain containing ossification factor | 0.0237567 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0236883 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0236124 |
| CEP350 | centrosomal protein 350kDa | 0.0235106 |
| SNX13 | sorting nexin 13 | 0.0233816 |
| CALU | calumenin | 0.0233405 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0233302 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0232031 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0231087 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0231081 |
| PHF3 | PHD finger protein 3 | 0.0230047 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0228739 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0228032 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0227604 |
| NUP58 | nucleoporin 58 | 0.0226783 |
| POU2F1 | POU class 2 homeobox 1 | 0.0224886 |
| ANO6 | anoctamin 6 | 0.0224267 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0223001 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0221994 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.245181 |
| LMO7 | LIM domain 7 | -0.138765 |
| ANXA2 | annexin A2 | -0.122971 |
| MYO1E | myosin IE | -0.118368 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10728 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0982529 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0790403 |
| FLNB | filamin B, beta | -0.0753974 |
| EZR | ezrin | -0.0717175 |
| MX1 | MX dynamin-like GTPase 1 | -0.0658362 |
| PKM | pyruvate kinase, muscle | -0.0653194 |
| ACTG1 | actin gamma 1 | -0.0647951 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.063762 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0602517 |
| RIGI | RNA sensor RIG-I | -0.0597228 |
| RNF213 | ring finger protein 213 | -0.0594249 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0586302 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0583505 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0581047 |
| ACTN4 | actinin, alpha 4 | -0.0527048 |
| SP100 | SP100 nuclear antigen | -0.0510435 |
| VCL | vinculin | -0.0494483 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0491103 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0490472 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0478485 |
| LAMA4 | laminin, alpha 4 | -0.0463492 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0463202 |
| RPLP1 | ribosomal protein, large, P1 | -0.046276 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0461621 |
| FBXO11 | F-box protein 11 | -0.0457159 |
| SLC38A2 | solute carrier family 38, member 2 | -0.044193 |
| OXSR1 | oxidative stress responsive 1 | -0.0435518 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0428348 |
| EGR1 | early growth response 1 | -0.042429 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0422302 |
| ITGA6 | integrin, alpha 6 | -0.0421658 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0421639 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0414222 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0413901 |
| PALLD | palladin, cytoskeletal associated protein | -0.040594 |
| CLDN4 | claudin 4 | -0.0400647 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0399733 |
| INTS6 | integrator complex subunit 6 | -0.0397002 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0395636 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0391788 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0385995 |
| MUC13 | mucin 13, cell surface associated | -0.0383376 |
| SERINC5 | serine incorporator 5 | -0.0383287 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0377985 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.037765 |
| SPON1 | spondin 1, extracellular matrix protein | -0.0372301 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0368942 |
| ITGB4 | integrin, beta 4 | -0.0358204 |
| TC2N | tandem C2 domains, nuclear | -0.035707 |
| DIAPH1 | diaphanous-related formin 1 | -0.0356902 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0349796 |
| RCOR1 | REST corepressor 1 | -0.0333095 |
| EPHA2 | EPH receptor A2 | -0.033145 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0327976 |
| NABP1 | nucleic acid binding protein 1 | -0.0324442 |
| PRSS3 | protease, serine, 3 | -0.032243 |
| MYOF | myoferlin | -0.0320297 |
| PLSCR1 | phospholipid scramblase 1 | -0.0317004 |
| MYO5B | myosin VB | -0.0316684 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0315531 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0315268 |
| RPS19 | ribosomal protein S19 | -0.0313852 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0313215 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0312419 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0309207 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.030718 |
| CLIC5 | chloride intracellular channel 5 | -0.0302379 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0301137 |
| MX2 | MX dynamin-like GTPase 2 | -0.0299467 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0298925 |
| HLA-B | major histocompatibility complex, class I, B | -0.0297712 |
| MT2A | metallothionein 2A | -0.0296061 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0295722 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0293335 |
| UBAP2 | ubiquitin associated protein 2 | -0.0292461 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0291868 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0291312 |
| CUX1 | cut-like homeobox 1 | -0.0283813 |
| TMSB10 | thymosin beta 10 | -0.028313 |
| CALB1 | calbindin 1, 28kDa | -0.0281292 |
| FRMD5 | FERM domain containing 5 | -0.0279508 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0276672 |
| CTBP2 | C-terminal binding protein 2 | -0.0274949 |
| KRT18 | keratin 18, type I | -0.0273869 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0268243 |
| FUS | FUS RNA binding protein | -0.0266225 |
| TJP1 | tight junction protein 1 | -0.0264001 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0263235 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0263184 |
| LAMB3 | laminin, beta 3 | -0.0262592 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0262411 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.025824 |
| SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20 | -0.025658 |
| POTEF | POTE ankyrin domain family, member F | -0.025652 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0252576 |
