| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0665564 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0495202 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0319162 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0301042 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.02712 |
| NUP58 | nucleoporin 58 | 0.0268668 |
| PRELID2 | PRELI domain containing 2 | 0.0245966 |
| ARRDC3 | arrestin domain containing 3 | 0.024495 |
| EREG | epiregulin | 0.0240591 |
| RPS2 | ribosomal protein S2 | 0.0234323 |
| TPM3 | tropomyosin 3 | 0.0213959 |
| HMGB2 | high mobility group box 2 | 0.021227 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0205781 |
| SPAG9 | sperm associated antigen 9 | 0.0203816 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0196695 |
| RPL23 | ribosomal protein L23 | 0.019161 |
| RPL21 | ribosomal protein L21 | 0.0188079 |
| KLF6 | Kruppel-like factor 6 | 0.0187084 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0175313 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0167777 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0167316 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0167112 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0158638 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0150033 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0147571 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0140648 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0137116 |
| KLHL15 | kelch-like family member 15 | 0.0136554 |
| RPS12 | ribosomal protein S12 | 0.0136553 |
| CCNL1 | cyclin L1 | 0.0135653 |
| MATR3 | matrin 3 | 0.0134496 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.013321 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0131717 |
| RPS7 | ribosomal protein S7 | 0.012508 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0122172 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0121082 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0120293 |
| PRDX1 | peroxiredoxin 1 | 0.0120236 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0120216 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0119796 |
| TMEM41B | transmembrane protein 41B | 0.0119101 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0119064 |
| RPL18 | ribosomal protein L18 | 0.0118909 |
| SEPTIN7 | septin 7 | 0.0115548 |
| PLIN2 | perilipin 2 | 0.0114885 |
| SLK | STE20-like kinase | 0.0113864 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0113107 |
| PNN | pinin, desmosome associated protein | 0.0110487 |
| OPTN | optineurin | 0.0110297 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0106302 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0106239 |
| RPL3 | ribosomal protein L3 | 0.0105394 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0104961 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0104776 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0103899 |
| ANXA1 | annexin A1 | 0.0103773 |
| MT2A | metallothionein 2A | 0.0103334 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0102724 |
| RPS18 | ribosomal protein S18 | 0.0102399 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0101597 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.010143 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0101077 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.00984579 |
| TAC4 | tachykinin 4 (hemokinin) | 0.00984036 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00975166 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.00972354 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0097197 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.00964977 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.00952332 |
| RRM2 | ribonucleotide reductase M2 | 0.00950992 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.00945757 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00931459 |
| CRY1 | cryptochrome circadian clock 1 | 0.00931172 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00927275 |
| SDC4 | syndecan 4 | 0.00927193 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00926691 |
| HDGF | hepatoma-derived growth factor | 0.00917514 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.00904775 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | 0.00900134 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00896112 |
| QKI | QKI, KH domain containing, RNA binding | 0.00889565 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0088283 |
| UBA5 | ubiquitin-like modifier activating enzyme 5 | 0.0088177 |
| PDE8A | phosphodiesterase 8A | 0.00879052 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00878908 |
| MTF2 | metal response element binding transcription factor 2 | 0.00877347 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.00875114 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00870584 |
| MSN | moesin | 0.00867418 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.00860777 |
| RIOK3 | RIO kinase 3 | 0.00858241 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00857961 |
| RBM17 | RNA binding motif protein 17 | 0.00850953 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00840291 |
| SET | SET nuclear proto-oncogene | 0.008285 |
| INSIG2 | insulin induced gene 2 | 0.00818354 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.00817772 |
| PEX3 | peroxisomal biogenesis factor 3 | 0.00813322 |
| YBX1 | Y box binding protein 1 | 0.00808525 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0080035 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.24407 |
| CD44 | CD44 molecule (Indian blood group) | -0.1885 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.171223 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.143087 |
| TP63 | tumor protein p63 | -0.140734 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.126939 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.114374 |
| VIM | vimentin | -0.113095 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.112712 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.103877 |
| EHBP1 | EH domain binding protein 1 | -0.0958737 |
| RIGI | RNA sensor RIG-I | -0.081622 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0810114 |
| APP | amyloid beta (A4) precursor protein | -0.0776173 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0769933 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0734982 |
| AHNAK | AHNAK nucleoprotein | -0.0723953 |
| HLA-B | major histocompatibility complex, class I, B | -0.071725 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0702433 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0675315 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0672792 |
| ACTG1 | actin gamma 1 | -0.0659721 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0606693 |
| CMIP | c-Maf inducing protein | -0.0604272 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0602906 |
| RUNX1 | runt-related transcription factor 1 | -0.059322 |
| PTMA | prothymosin, alpha | -0.058175 |
| TNS3 | tensin 3 | -0.056546 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0545104 |
| RPL35A | ribosomal protein L35a | -0.0541503 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0536432 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0524823 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0520097 |
| RNF213 | ring finger protein 213 | -0.051819 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0516262 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0507557 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0507319 |
| EPHA4 | EPH receptor A4 | -0.0504289 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0501609 |
| FMNL2 | formin-like 2 | -0.0501191 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0496473 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0487514 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0487224 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0484049 |
| EXOC4 | exocyst complex component 4 | -0.0477008 |
| DST | dystonin | -0.0474909 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0473267 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0472355 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0463538 |
| SP100 | SP100 nuclear antigen | -0.0463452 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0458937 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0454506 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.045162 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0450872 |
| TXNRD1 | thioredoxin reductase 1 | -0.0449342 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0440427 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0439985 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0439465 |
| HDLBP | high density lipoprotein binding protein | -0.0432835 |
| FTL | ferritin, light polypeptide | -0.0432616 |
| CADM2 | cell adhesion molecule 2 | -0.0430715 |
| RPL31 | ribosomal protein L31 | -0.0427424 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0422098 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0421455 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0417197 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0411816 |
| CANX | calnexin | -0.0404966 |
| EFNA5 | ephrin-A5 | -0.0398808 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0396092 |
| DNER | delta/notch-like EGF repeat containing | -0.03959 |
| RAD51B | RAD51 paralog B | -0.0394699 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0393008 |
| HMGA1 | high mobility group AT-hook 1 | -0.0391312 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0391276 |
| RPS29 | ribosomal protein S29 | -0.0388308 |
| PTK2 | protein tyrosine kinase 2 | -0.0385983 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0382313 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0376002 |
| LOXL2 | lysyl oxidase-like 2 | -0.0373129 |
| PDE10A | phosphodiesterase 10A | -0.0372121 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0369983 |
| VCL | vinculin | -0.0369428 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0367061 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0363286 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.036181 |
| THOC2 | THO complex 2 | -0.0360225 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0357873 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0353201 |
| PODXL | podocalyxin-like | -0.0348544 |
| RAB27B | RAB27B, member RAS oncogene family | -0.034614 |
| GLG1 | golgi glycoprotein 1 | -0.0344859 |
| MAP4 | microtubule-associated protein 4 | -0.0344238 |
| KPNB1 | karyopherin (importin) beta 1 | -0.034423 |
| PGK1 | phosphoglycerate kinase 1 | -0.0343342 |
| NF1 | neurofibromin 1 | -0.0338273 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0338188 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0331388 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0326931 |
| RPS23 | ribosomal protein S23 | -0.0326266 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0325641 |
