| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0732537 |
| ATP13A3 | ATPase type 13A3 | 0.0623889 |
| TES | testin LIM domain protein | 0.0569266 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0548027 |
| ARRDC3 | arrestin domain containing 3 | 0.0540829 |
| VMP1 | vacuole membrane protein 1 | 0.0472804 |
| MKI67 | marker of proliferation Ki-67 | 0.0454158 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0375583 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0357944 |
| YTHDC1 | YTH domain containing 1 | 0.0354459 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0344143 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0337488 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0335901 |
| RUNX1 | runt-related transcription factor 1 | 0.032352 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0321172 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0316559 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0309611 |
| NPTN | neuroplastin | 0.0304458 |
| NEK7 | NIMA-related kinase 7 | 0.0301265 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0299749 |
| CCNL1 | cyclin L1 | 0.0298685 |
| HELZ | helicase with zinc finger | 0.0289947 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0288649 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286671 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0282782 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0281554 |
| NUP58 | nucleoporin 58 | 0.0280123 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.027647 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0268847 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0264908 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0263255 |
| SUCO | SUN domain containing ossification factor | 0.0262818 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0261736 |
| RBM39 | RNA binding motif protein 39 | 0.0259775 |
| GPC6 | glypican 6 | 0.0256821 |
| BBX | bobby sox homolog (Drosophila) | 0.0255643 |
| PTK2 | protein tyrosine kinase 2 | 0.0253546 |
| ZNF638 | zinc finger protein 638 | 0.0249727 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0248515 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0248467 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0247871 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0246597 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.02448 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0244419 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0242395 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0241097 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0240806 |
| XPO1 | exportin 1 | 0.0238524 |
| DENND4A | DENN/MADD domain containing 4A | 0.0236195 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0235367 |
| RLF | rearranged L-myc fusion | 0.0234906 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0226786 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0226036 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0223731 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0222949 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0221355 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0221045 |
| ZNF654 | zinc finger protein 654 | 0.0217834 |
| DTNA | dystrobrevin, alpha | 0.0212425 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.021195 |
| RAD51B | RAD51 paralog B | 0.0210829 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0210739 |
| MEF2A | myocyte enhancer factor 2A | 0.0209689 |
| SERINC3 | serine incorporator 3 | 0.020825 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0205928 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0205534 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0204972 |
| RTN4 | reticulon 4 | 0.0204796 |
| JMJD1C | jumonji domain containing 1C | 0.0204033 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0202312 |
| CUL3 | cullin 3 | 0.0201604 |
| CENPF | centromere protein F, 350/400kDa | 0.0198365 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0197795 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0196406 |
| FAM13A | family with sequence similarity 13, member A | 0.0195859 |
| NCKAP1 | NCK-associated protein 1 | 0.019539 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0195351 |
| TMF1 | TATA element modulatory factor 1 | 0.0194675 |
| ECT2 | epithelial cell transforming 2 | 0.0194426 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.01933 |
| ABI1 | abl-interactor 1 | 0.0191876 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0191594 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0191275 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.019115 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.0190561 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0190077 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0184933 |
| MYO5B | myosin VB | 0.0183262 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0181572 |
| UVRAG | UV radiation resistance associated | 0.0181241 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0180798 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0179556 |
| MED13L | mediator complex subunit 13-like | 0.017946 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0179271 |
| ZNF207 | zinc finger protein 207 | 0.0179238 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0178215 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0177497 |
| POU2F1 | POU class 2 homeobox 1 | 0.0176085 |
| KIAA1328 | KIAA1328 | 0.0175333 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0174986 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.33848 |
| TMSB10 | thymosin beta 10 | -0.244394 |
| NDRG1 | N-myc downstream regulated 1 | -0.159871 |
| TXNRD1 | thioredoxin reductase 1 | -0.153575 |
| RPS3 | ribosomal protein S3 | -0.144752 |
| FTL | ferritin, light polypeptide | -0.144406 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.109415 |
| MT2A | metallothionein 2A | -0.0975514 |
| LAMC2 | laminin, gamma 2 | -0.0964771 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0912634 |
| ASPH | aspartate beta-hydroxylase | -0.0881729 |
| H1-0 | H1.0 linker histone | -0.0863406 |
| RPL35A | ribosomal protein L35a | -0.0844408 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0833263 |
| SEC61G | Sec61 gamma subunit | -0.0769574 |
| RPL37A | ribosomal protein L37a | -0.0763736 |
| PKM | pyruvate kinase, muscle | -0.0736354 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0717418 |
| LAMA4 | laminin, alpha 4 | -0.0712758 |
| PTMA | prothymosin, alpha | -0.0696522 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.063393 |
| RPS12 | ribosomal protein S12 | -0.0616414 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0609081 |
| RPS8 | ribosomal protein S8 | -0.0601934 |
| OSMR | oncostatin M receptor | -0.0601744 |
| GRAMD1B | GRAM domain containing 1B | -0.0599158 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0588981 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.057813 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0571775 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0566976 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.055768 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0556387 |
| EGR1 | early growth response 1 | -0.0519445 |
| RNF213 | ring finger protein 213 | -0.0515528 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0496226 |
| S100P | S100 calcium binding protein P | -0.048198 |
| RPL34 | ribosomal protein L34 | -0.0480548 |
| NABP1 | nucleic acid binding protein 1 | -0.0476826 |
| LDHA | lactate dehydrogenase A | -0.0473719 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0472003 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0466597 |
| ANXA2 | annexin A2 | -0.0458053 |
| RPS27A | ribosomal protein S27a | -0.0452393 |
| ACTG1 | actin gamma 1 | -0.0447645 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0444944 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0443158 |
| RPS27 | ribosomal protein S27 | -0.0442672 |
| SQSTM1 | sequestosome 1 | -0.0439277 |
| RPS25 | ribosomal protein S25 | -0.0432825 |
| WASF2 | WAS protein family, member 2 | -0.0412693 |
| LMO7 | LIM domain 7 | -0.0399618 |
| CSTB | cystatin B (stefin B) | -0.0397452 |
| PGK1 | phosphoglycerate kinase 1 | -0.0395063 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0393091 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0391601 |
| RPLP1 | ribosomal protein, large, P1 | -0.0390199 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0381181 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0380046 |
| HMGA1 | high mobility group AT-hook 1 | -0.0376215 |
| B2M | beta-2-microglobulin | -0.0375041 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0374483 |
| SEPTIN2 | septin 2 | -0.0372279 |
| CD163L1 | CD163 molecule-like 1 | -0.0368059 |
| RPS17 | ribosomal protein S17 | -0.0367441 |
| CST3 | cystatin C | -0.0360063 |
| AHNAK | AHNAK nucleoprotein | -0.0359664 |
| MCL1 | myeloid cell leukemia 1 | -0.0351881 |
| NPAS2 | neuronal PAS domain protein 2 | -0.035034 |
| RPL26 | ribosomal protein L26 | -0.0341308 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0341133 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0338663 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0336382 |
| HM13 | histocompatibility (minor) 13 | -0.0334685 |
| TMEM165 | transmembrane protein 165 | -0.0332779 |
| SCEL | sciellin | -0.0331785 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0328626 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0326544 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0325598 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0325002 |
| RPL31 | ribosomal protein L31 | -0.0324799 |
| KRT7 | keratin 7, type II | -0.0322127 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0319554 |
| RPS24 | ribosomal protein S24 | -0.0318888 |
| ABLIM1 | actin binding LIM protein 1 | -0.0315959 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0314606 |
| GNAS | GNAS complex locus | -0.0312822 |
| RPLP2 | ribosomal protein, large, P2 | -0.0311738 |
| RACK1 | receptor for activated C kinase 1 | -0.0310487 |
| RPL23 | ribosomal protein L23 | -0.031003 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0308959 |
| S100A9 | S100 calcium binding protein A9 | -0.0306474 |
| LAMB3 | laminin, beta 3 | -0.0305634 |
| SERF2 | small EDRK-rich factor 2 | -0.030251 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.029014 |
| RPL36 | ribosomal protein L36 | -0.0288652 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0287041 |
| PLEC | plectin | -0.0285788 |
| KRT18 | keratin 18, type I | -0.0285497 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0284425 |
| GM2A | GM2 ganglioside activator | -0.0283751 |
