| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.132553 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.124577 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0999164 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.086964 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0839416 |
| PRELID2 | PRELI domain containing 2 | 0.0838989 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.080585 |
| RBM39 | RNA binding motif protein 39 | 0.0735693 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0730276 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0722171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0682942 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0645085 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0633864 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0606957 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0586425 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0521228 |
| HELZ | helicase with zinc finger | 0.0516115 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0515988 |
| GOLGA4 | golgin A4 | 0.0511038 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0504235 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0492958 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0489974 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0486833 |
| OGA | O-GlcNAcase | 0.0485366 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0468371 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0459742 |
| ZNF292 | zinc finger protein 292 | 0.045127 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0450682 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0449341 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0443153 |
| USP3 | ubiquitin specific peptidase 3 | 0.0439527 |
| FMNL2 | formin-like 2 | 0.0431428 |
| NGLY1 | N-glycanase 1 | 0.0427915 |
| CCNY | cyclin Y | 0.0418439 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0406003 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0403835 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0403406 |
| MEF2A | myocyte enhancer factor 2A | 0.0399298 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0381656 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0379052 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0375106 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0369722 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0364516 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0362544 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.035923 |
| RIOK3 | RIO kinase 3 | 0.0348495 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0347878 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0343469 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0337989 |
| XPO1 | exportin 1 | 0.033569 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0332335 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0328405 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0317059 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0316386 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0311356 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0311034 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0310349 |
| YEATS2 | YEATS domain containing 2 | 0.0310037 |
| ATP13A3 | ATPase type 13A3 | 0.0309199 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0307881 |
| RNF145 | ring finger protein 145 | 0.0307497 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0306998 |
| TPD52 | tumor protein D52 | 0.0302233 |
| RLF | rearranged L-myc fusion | 0.0297686 |
| ENO1 | enolase 1, (alpha) | 0.0290374 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0289925 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0289894 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0289271 |
| MATR3 | matrin 3 | 0.0289146 |
| CDH13 | cadherin 13 | 0.0288781 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.028798 |
| PTMA | prothymosin, alpha | 0.0287562 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0287504 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0287036 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0285927 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0285441 |
| KIF5B | kinesin family member 5B | 0.028372 |
| SPAG9 | sperm associated antigen 9 | 0.0280907 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0280038 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0277099 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0276035 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0275839 |
| PGK1 | phosphoglycerate kinase 1 | 0.0275665 |
| APP | amyloid beta (A4) precursor protein | 0.0274507 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0270462 |
| PTK2 | protein tyrosine kinase 2 | 0.0269513 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0267819 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.026554 |
| QKI | QKI, KH domain containing, RNA binding | 0.0265221 |
| MTSS1 | metastasis suppressor 1 | 0.0258838 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0258677 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0258656 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0251996 |
| SEPTIN7 | septin 7 | 0.0249596 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0249405 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0249146 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0247456 |
| NEK7 | NIMA-related kinase 7 | 0.0246845 |
| DTNA | dystrobrevin, alpha | 0.0246695 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0239554 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.199625 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.194438 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.147758 |
| OSMR | oncostatin M receptor | -0.126283 |
| GLCCI1 | glucocorticoid induced 1 | -0.12149 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.102374 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0932791 |
| VIM | vimentin | -0.0908856 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0839806 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0792825 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0782527 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0768983 |
| LOX | lysyl oxidase | -0.0741473 |
| NTN4 | netrin 4 | -0.0713213 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0702257 |
| EGR1 | early growth response 1 | -0.0674007 |
| TMSB10 | thymosin beta 10 | -0.0665514 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0649711 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0646318 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0631594 |
| EGFR | epidermal growth factor receptor | -0.0627766 |
| KYNU | kynureninase | -0.0620624 |
| FTL | ferritin, light polypeptide | -0.0565826 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0552952 |
| NRP1 | neuropilin 1 | -0.0550379 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0544352 |
| TNNC1 | troponin C type 1 (slow) | -0.0517556 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.051654 |
| TGM2 | transglutaminase 2 | -0.0507567 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.050262 |
| IL1R1 | interleukin 1 receptor, type I | -0.0483994 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0478296 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0473585 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0437732 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0435437 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0426894 |
| MT2A | metallothionein 2A | -0.0418892 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0414976 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0414176 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0407112 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0401456 |
| KSR1 | kinase suppressor of ras 1 | -0.0400831 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0397902 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0381472 |
| HMGA1 | high mobility group AT-hook 1 | -0.0381408 |
| STK38L | serine/threonine kinase 38 like | -0.0377772 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0376912 |
| HMGA2 | high mobility group AT-hook 2 | -0.0373266 |
| RNF24 | ring finger protein 24 | -0.0373137 |
| VMP1 | vacuole membrane protein 1 | -0.0371618 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0370607 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0369187 |
| FN1 | fibronectin 1 | -0.0363425 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0357671 |
| VCL | vinculin | -0.0353142 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0342804 |
| BPTF | bromodomain PHD finger transcription factor | -0.0338065 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0335637 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.033311 |
| AADAC | arylacetamide deacetylase | -0.032095 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0318789 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | -0.0317468 |
| ECE1 | endothelin converting enzyme 1 | -0.030977 |
| DUSP16 | dual specificity phosphatase 16 | -0.0306569 |
| NDRG1 | N-myc downstream regulated 1 | -0.0304929 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0303449 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.030293 |
| EHBP1 | EH domain binding protein 1 | -0.0301484 |
| NABP1 | nucleic acid binding protein 1 | -0.0298584 |
| COPA | coatomer protein complex, subunit alpha | -0.0297373 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0291171 |
| SYAP1 | synapse associated protein 1 | -0.0289998 |
| FRMD4A | FERM domain containing 4A | -0.0283961 |
| TUT7 | terminal uridylyl transferase 7 | -0.0283233 |
| VRK2 | vaccinia related kinase 2 | -0.0281855 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0280254 |
| AOPEP | aminopeptidase O (putative) | -0.0278484 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0273009 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0272572 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.0270456 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0266356 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0266093 |
| MEIS1 | Meis homeobox 1 | -0.0265987 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0260102 |
| RPS19 | ribosomal protein S19 | -0.025952 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0258559 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0257042 |
| PHF14 | PHD finger protein 14 | -0.0255664 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0255655 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0254504 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0253062 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0250571 |
| EFNA5 | ephrin-A5 | -0.0248943 |
| RPLP1 | ribosomal protein, large, P1 | -0.0246257 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0246136 |
| MAP1B | microtubule-associated protein 1B | -0.024609 |
| PCNX4 | pecanex 4 | -0.0245573 |
| ATF7 | activating transcription factor 7 | -0.0245412 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0245145 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0243417 |
