| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.178461 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118114 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0713551 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.067273 |
| TPM3 | tropomyosin 3 | 0.0635014 |
| FMNL2 | formin-like 2 | 0.0634457 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0624982 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0615458 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0598719 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0572822 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0565271 |
| TFG | TRK-fused gene | 0.053679 |
| GOLGA4 | golgin A4 | 0.0481975 |
| PYGL | phosphorylase, glycogen, liver | 0.0451071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0446708 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0440372 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0437324 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0412835 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0411577 |
| USP3 | ubiquitin specific peptidase 3 | 0.0410554 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0406987 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0401725 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0395659 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0388495 |
| S100A10 | S100 calcium binding protein A10 | 0.0387993 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0372851 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0370804 |
| FNBP1L | formin binding protein 1-like | 0.0363719 |
| S100A6 | S100 calcium binding protein A6 | 0.0361977 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0361501 |
| ENO1 | enolase 1, (alpha) | 0.0354312 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0346658 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0338804 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0326718 |
| MSN | moesin | 0.0320453 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0315249 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0312271 |
| SLMAP | sarcolemma associated protein | 0.0309742 |
| MATR3 | matrin 3 | 0.0308856 |
| SEPTIN7 | septin 7 | 0.0299916 |
| FLNB | filamin B, beta | 0.0299796 |
| ANXA5 | annexin A5 | 0.029151 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0289583 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0287644 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0286757 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.028416 |
| POTEF | POTE ankyrin domain family, member F | 0.0281182 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0280766 |
| KIF5B | kinesin family member 5B | 0.0279527 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0278313 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0277871 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0277151 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0273114 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0271473 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0265432 |
| PGK1 | phosphoglycerate kinase 1 | 0.0261737 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0261381 |
| NCKAP1 | NCK-associated protein 1 | 0.0261324 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0260078 |
| CANX | calnexin | 0.0259804 |
| CALU | calumenin | 0.0259013 |
| CALR | calreticulin | 0.0258484 |
| RBM39 | RNA binding motif protein 39 | 0.0256922 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0256487 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0253878 |
| CDC73 | cell division cycle 73 | 0.0251882 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0251061 |
| CCNL1 | cyclin L1 | 0.0250111 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0247301 |
| HDGF | hepatoma-derived growth factor | 0.024603 |
| NEMF | nuclear export mediator factor | 0.0243988 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0241698 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0241184 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0241046 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0238973 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0238674 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0236018 |
| NDRG1 | N-myc downstream regulated 1 | 0.0235456 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0234848 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0234578 |
| LDHA | lactate dehydrogenase A | 0.0234318 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0233202 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0232255 |
| PARD3 | par-3 family cell polarity regulator | 0.0231297 |
| STC1 | stanniocalcin 1 | 0.0230229 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.022965 |
| PRR16 | proline rich 16 | 0.0228752 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0228546 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0228529 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0226476 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0225725 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0225201 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0225024 |
| ZNF292 | zinc finger protein 292 | 0.0223387 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0222908 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0222901 |
| SPAG9 | sperm associated antigen 9 | 0.0222428 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0220735 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0220463 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0219682 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.251415 |
| PM20D1 | peptidase M20 domain containing 1 | -0.236225 |
| GRAMD1B | GRAM domain containing 1B | -0.200318 |
| TXNRD1 | thioredoxin reductase 1 | -0.158127 |
| TMSB10 | thymosin beta 10 | -0.135009 |
| FTL | ferritin, light polypeptide | -0.128188 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0946805 |
| HDAC9 | histone deacetylase 9 | -0.0729515 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0659186 |
| KYNU | kynureninase | -0.0658017 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0640699 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0559534 |
| EGR1 | early growth response 1 | -0.0551132 |
| NTN4 | netrin 4 | -0.0529528 |
| RPL19 | ribosomal protein L19 | -0.0507164 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0497409 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0480117 |
| OSMR | oncostatin M receptor | -0.047584 |
| KLF6 | Kruppel-like factor 6 | -0.0449863 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0448768 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0442334 |
| RPL36 | ribosomal protein L36 | -0.0426745 |
| NABP1 | nucleic acid binding protein 1 | -0.0396836 |
| IER3 | immediate early response 3 | -0.0396357 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0394392 |
| RPS19 | ribosomal protein S19 | -0.0391082 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0371595 |
| BICC1 | BicC family RNA binding protein 1 | -0.0360684 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0355614 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0349637 |
| IGF2 | insulin-like growth factor 2 | -0.0335259 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0328396 |
| SVIL | supervillin | -0.0320329 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0319315 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0318557 |
| ZNF804A | zinc finger protein 804A | -0.0310785 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0308038 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0300191 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.029707 |
| RPS8 | ribosomal protein S8 | -0.0294718 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0290781 |
| VMP1 | vacuole membrane protein 1 | -0.028301 |
| BMP5 | bone morphogenetic protein 5 | -0.0281124 |
| MCL1 | myeloid cell leukemia 1 | -0.0273883 |
| RPS29 | ribosomal protein S29 | -0.0272841 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0263571 |
| WWOX | WW domain containing oxidoreductase | -0.0262672 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0257011 |
| SQSTM1 | sequestosome 1 | -0.0254351 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0253749 |
| RPL37A | ribosomal protein L37a | -0.0249971 |
| RPLP1 | ribosomal protein, large, P1 | -0.0248803 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0246989 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0244063 |
| RPS12 | ribosomal protein S12 | -0.0240419 |
| RPL23 | ribosomal protein L23 | -0.0240148 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0236442 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0232567 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0231923 |
| GLIS3 | GLIS family zinc finger 3 | -0.0226905 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0226327 |
| RHEB | Ras homolog enriched in brain | -0.0224308 |
| RPLP2 | ribosomal protein, large, P2 | -0.0221757 |
| NRG1 | neuregulin 1 | -0.0220268 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0214243 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0213858 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.021382 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.021269 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0211328 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.0211144 |
| RPS27 | ribosomal protein S27 | -0.0210877 |
| CENPE | centromere protein E, 312kDa | -0.0207938 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0195135 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0193455 |
| SMAD2 | SMAD family member 2 | -0.0193064 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.019182 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0188649 |
| SERF2 | small EDRK-rich factor 2 | -0.0188552 |
| EPGN | epithelial mitogen | -0.0187143 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0186733 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0185057 |
| RSPO3 | R-spondin 3 | -0.0183062 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0182705 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0182681 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0181431 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0180988 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0180926 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0179711 |
| RPS14 | ribosomal protein S14 | -0.0178054 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0177909 |
| RPS17 | ribosomal protein S17 | -0.0176615 |
| TDP2 | tyrosyl-DNA phosphodiesterase 2 | -0.0176253 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0176002 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0175483 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0174735 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0174486 |
| AK1 | adenylate kinase 1 | -0.017005 |
| PDE10A | phosphodiesterase 10A | -0.0168893 |
| INO80 | INO80 complex subunit | -0.0168526 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0168359 |
