Bosentan (hydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

179 genes differentially expressed following the Bosentan (hydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.177606
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.160522
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.131461
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.129495
ZNF292 zinc finger protein 292 0.128048
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.11037
RERE arginine-glutamic acid dipeptide (RE) repeats 0.103199
MT2A metallothionein 2A 0.0993051
PRRC2C proline-rich coiled-coil 2C 0.0987661
LDHA lactate dehydrogenase A 0.0904491
PIAS2 protein inhibitor of activated STAT, 2 0.0788565
ENO1 enolase 1, (alpha) 0.0736412
MYOF myoferlin 0.0705238
PHC3 polyhomeotic homolog 3 (Drosophila) 0.070466
ETNK1 ethanolamine kinase 1 0.0677196
ZEB1 zinc finger E-box binding homeobox 1 0.0663481
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0661613
TTC17 tetratricopeptide repeat domain 17 0.0647035
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.062879
KDM6A lysine (K)-specific demethylase 6A 0.0628404
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0594772
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0560516
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.053663
NCOR1 nuclear receptor corepressor 1 0.053196
TTC3 tetratricopeptide repeat domain 3 0.0513374
THOC2 THO complex 2 0.0496722
MED13L mediator complex subunit 13-like 0.0490737
CXCL8 chemokine (C-X-C motif) ligand 8 0.0488676
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0478196
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0473266
FAM13A family with sequence similarity 13, member A 0.0454052
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0451649
NDRG1 N-myc downstream regulated 1 0.0444331
KMT2A lysine (K)-specific methyltransferase 2A 0.0440723
CANX calnexin 0.0406016
PTMA prothymosin, alpha 0.0395976
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0388835
EIF1 eukaryotic translation initiation factor 1 0.0378244
RACK1 receptor for activated C kinase 1 0.0377522
SETD5 SET domain containing 5 0.0372185
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0369961
ANKRD17 ankyrin repeat domain 17 0.0362756
STRN3 striatin, calmodulin binding protein 3 0.0356388
RPLP0 ribosomal protein, large, P0 0.0354755
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0340099
LOC112694756 uncharaterized LOC112694756 0.0335644
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0333845
RPL11 ribosomal protein L11 0.0333774
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332145
RPS12 ribosomal protein S12 0.0311782
RPS27A ribosomal protein S27a 0.0311618
NAMPT nicotinamide phosphoribosyltransferase 0.0309066
APP amyloid beta (A4) precursor protein 0.0297773
IGF2R insulin-like growth factor 2 receptor 0.0292083
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0288909
DST dystonin 0.027974
PDE10A phosphodiesterase 10A 0.0276932
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0276199
NKD1 naked cuticle homolog 1 (Drosophila) 0.0275157
TRIO trio Rho guanine nucleotide exchange factor 0.0274485
CDCP1 CUB domain containing protein 1 0.0273937
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273246
RPS3 ribosomal protein S3 0.0270513
ARHGAP5 Rho GTPase activating protein 5 0.0270032
GLG1 golgi glycoprotein 1 0.0268684
RPL26 ribosomal protein L26 0.0266041
AKAP12 A kinase (PRKA) anchor protein 12 0.0260065
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0259409
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0252372
FNDC3B fibronectin type III domain containing 3B 0.02523
RPS14 ribosomal protein S14 0.0244676
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239988
RPL30 ribosomal protein L30 0.0231819
RPS6 ribosomal protein S6 0.0226624
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224861
LPP LIM domain containing preferred translocation partner in lipoma 0.0223734
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0215918
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0196502
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0188842
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0187049
DSCAM Down syndrome cell adhesion molecule 0.017975
TPT1 tumor protein, translationally-controlled 1 0.0176179
ACTG1 actin gamma 1 0.0169065
AKAP9 A kinase (PRKA) anchor protein 9 0.0163936
RPL37A ribosomal protein L37a 0.0163396
NEBL nebulette 0.0162781
CD44 CD44 molecule (Indian blood group) 0.0158281
NPEPPS aminopeptidase puromycin sensitive 0.0140014
HDAC9 histone deacetylase 9 0.0136645
DPYD dihydropyrimidine dehydrogenase 0.0125777
KMT2E lysine (K)-specific methyltransferase 2E 0.0122703
RPL12 ribosomal protein L12 0.0120008
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00957685
RSL24D1 ribosomal L24 domain containing 1 0.00924944
ZMYM2 zinc finger, MYM-type 2 0.00866282
PRELID2 PRELI domain containing 2 0.00815865
BIRC6 baculoviral IAP repeat containing 6 0.00764829
SLC38A2 solute carrier family 38, member 2 0.00763199
RPL31 ribosomal protein L31 0.00741777
RBM39 RNA binding motif protein 39 0.00697822

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.297986
SAMD4A sterile alpha motif domain containing 4A -0.175664
MYO1E myosin IE -0.17047
CEMIP cell migration inducing protein, hyaluronan binding -0.169104
LMO7 LIM domain 7 -0.157522
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.153389
ATOSA atos homolog A -0.1353
LAMB3 laminin, beta 3 -0.132379
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.107872
SLTM SAFB-like, transcription modulator -0.10238
FTH1 ferritin, heavy polypeptide 1 -0.100659
BACE2 beta-site APP-cleaving enzyme 2 -0.0976048
MACF1 microtubule-actin crosslinking factor 1 -0.090766
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0834492
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0766869
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.074329
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0729374
TXNRD1 thioredoxin reductase 1 -0.0721022
COL6A3 collagen, type VI, alpha 3 -0.0710248
VCL vinculin -0.0691404
PICALM phosphatidylinositol binding clathrin assembly protein -0.0667696
ANXA2 annexin A2 -0.0665692
ERBIN erbb2 interacting protein -0.0665485
FTL ferritin, light polypeptide -0.0650719
FN1 fibronectin 1 -0.0627344
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0609505
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.059418
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.058849
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0563455
EGFR epidermal growth factor receptor -0.0562351
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0543806
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0520757
SLC38A1 solute carrier family 38, member 1 -0.0487375
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.048671
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0480088
FNDC3A fibronectin type III domain containing 3A -0.0471065
JMJD1C jumonji domain containing 1C -0.0464917
PDE4D phosphodiesterase 4D, cAMP-specific -0.0431929
INHBA inhibin, beta A -0.0430758
B2M beta-2-microglobulin -0.0421852
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0325087
USP34 ubiquitin specific peptidase 34 -0.031787
PARD3 par-3 family cell polarity regulator -0.0310502
ZFAND3 zinc finger, AN1-type domain 3 -0.0299716
PTK2 protein tyrosine kinase 2 -0.0297281
DOCK5 dedicator of cytokinesis 5 -0.0294592
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.029265
WSB1 WD repeat and SOCS box containing 1 -0.0279918
SPAG9 sperm associated antigen 9 -0.0270317
EFNA5 ephrin-A5 -0.0268403
AHNAK AHNAK nucleoprotein -0.021767
NF1 neurofibromin 1 -0.0207802
PKM pyruvate kinase, muscle -0.0191726
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0183322
EXT1 exostosin glycosyltransferase 1 -0.0175351
RUNX1 runt-related transcription factor 1 -0.0173117
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0172826
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0172631
RPL35A ribosomal protein L35a -0.0169327
ASPH aspartate beta-hydroxylase -0.016773
CSNK1A1 casein kinase 1, alpha 1 -0.0160698
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.014936
ANKRD12 ankyrin repeat domain 12 -0.0135568
SMYD3 SET and MYND domain containing 3 -0.0134642
ANXA1 annexin A1 -0.0127186
NALF1 NALCN channel auxiliary factor 1 -0.0126279
KMT2C lysine (K)-specific methyltransferase 2C -0.0123791
RNF213 ring finger protein 213 -0.00953901
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00939796
COPB1 coatomer protein complex, subunit beta 1 -0.00628469
RPL7A ribosomal protein L7a -0.00628469
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.00481943
HM13 histocompatibility (minor) 13 -0.00476569
AGO2 argonaute RISC catalytic component 2 -0.0044231
GOLGA4 golgin A4 -0.0026416
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00260552
GOLGB1 golgin B1 -9.12122E-4
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -7.20342E-4
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -1.67032E-4