Bosentan (hydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0361927
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206662
RTN4 reticulon 4 0.0166804
ERRFI1 ERBB receptor feedback inhibitor 1 0.0165993
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0156923
ANKRD36 ankyrin repeat domain 36 0.0154887
KDM3A lysine (K)-specific demethylase 3A 0.0152068
CAMTA1 calmodulin binding transcription activator 1 0.0136619
GOLGA4 golgin A4 0.012624
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0120075
OGA O-GlcNAcase 0.0116582
NAMPT nicotinamide phosphoribosyltransferase 0.0115295
PCNX1 pecanex 1 0.0115113
SPAG9 sperm associated antigen 9 0.0114879
KDM6A lysine (K)-specific demethylase 6A 0.0114272
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0110493
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0110053
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0106695
PPME1 protein phosphatase methylesterase 1 0.00994468
RASAL2 RAS protein activator like 2 0.00988087
ADAM9 ADAM metallopeptidase domain 9 0.00946719
CAMKMT calmodulin-lysine N-methyltransferase 0.00920986
EIF4B eukaryotic translation initiation factor 4B 0.00919571
MYO6 myosin VI 0.00918181
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00916458
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00911294
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00905075
NCKAP1 NCK-associated protein 1 0.00901106
ZFAND3 zinc finger, AN1-type domain 3 0.00900624
TFG TRK-fused gene 0.00896444
RBM33 RNA binding motif protein 33 0.00892381
ETNK1 ethanolamine kinase 1 0.00891768
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.00888834
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.00875938
USP24 ubiquitin specific peptidase 24 0.00873118
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.008616
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00856609
RAP1A RAP1A, member of RAS oncogene family 0.00850198
RNF169 ring finger protein 169 0.00848221
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.00844167
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00843637
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.00820303
COG5 component of oligomeric golgi complex 5 0.00796445
CAND1 cullin-associated and neddylation-dissociated 1 0.0077615
CRY1 cryptochrome circadian clock 1 0.00775945
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00767792
WDR43 WD repeat domain 43 0.00762622
NUP58 nucleoporin 58 0.00756258
RUSC2 RUN and SH3 domain containing 2 0.00736648
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.00730102
TOP2B topoisomerase (DNA) II beta 180kDa 0.00729928
TNRC6A trinucleotide repeat containing 6A 0.00725754
TRIM33 tripartite motif containing 33 0.00724522
PCCA propionyl CoA carboxylase, alpha polypeptide 0.007133
RLIM ring finger protein, LIM domain interacting 0.00708446
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.00707213
NEK7 NIMA-related kinase 7 0.00705385
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00704793
UBQLN1 ubiquilin 1 0.00698984
PREPL prolyl endopeptidase-like 0.00695941
SKIC3 SKI3 subunit of superkiller complex 0.00693121
OSBPL8 oxysterol binding protein-like 8 0.00690092
CHD7 chromodomain helicase DNA binding protein 7 0.00688689
C2CD5 C2 calcium-dependent domain containing 5 0.0068854
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.00687983
TMEM41B transmembrane protein 41B 0.00681855
ARRDC3 arrestin domain containing 3 0.00675676
H1-3 H1.3 linker histone, cluster member 0.0067312
SINHCAF SIN3-HDAC complex associated factor 0.00672056
RIMKLB ribosomal modification protein rimK-like family member B 0.00671446
MON2 MON2 homolog (S. cerevisiae) 0.00670493
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00666744
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.00660477
BLTP3B bridge-like lipid transfer protein family member 3B 0.00658879
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00653706
CTTNBP2NL CTTNBP2 N-terminal like 0.00651831
ZFC3H1 zinc finger, C3H1-type containing 0.00651127
RAB3IP RAB3A interacting protein 0.00646577
FIP1L1 factor interacting with PAPOLA and CPSF1 0.00645225
KDM7A lysine (K)-specific demethylase 7A 0.00645091
FOXN2 forkhead box N2 0.00643947
ATL2 atlastin GTPase 2 0.00643629
RSRC1 arginine/serine-rich coiled-coil 1 0.0064341
SF1 splicing factor 1 0.00643145
STX16 syntaxin 16 0.00641719
RFX7 regulatory factor X, 7 0.00637554
PDS5B PDS5 cohesin associated factor B 0.00637231
GMCL1 germ cell-less, spermatogenesis associated 1 0.00635256
SNX27 sorting nexin family member 27 0.00628657
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.00625715
PTEN phosphatase and tensin homolog 0.00625311
ARHGAP12 Rho GTPase activating protein 12 0.00624547
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00624343
TMPO thymopoietin 0.00623876
HBP1 HMG-box transcription factor 1 0.00623634
RNF145 ring finger protein 145 0.00622617
SPAG5 sperm associated antigen 5 0.00620384
ECPAS Ecm29 proteasome adaptor and scaffold 0.00611235
WRN Werner syndrome, RecQ helicase-like 0.00606692
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.00605212

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153611
AKAP12 A kinase (PRKA) anchor protein 12 -0.133309
TMSB10 thymosin beta 10 -0.102595
VIM vimentin -0.0838355
PTMA prothymosin, alpha -0.0814672
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0812894
YBX3 Y box binding protein 3 -0.0656627
TPI1 triosephosphate isomerase 1 -0.0586453
RPL23 ribosomal protein L23 -0.0547159
RPS3 ribosomal protein S3 -0.0539445
RPL35A ribosomal protein L35a -0.0528132
RPL26 ribosomal protein L26 -0.0483163
RPS8 ribosomal protein S8 -0.0450658
RPS19 ribosomal protein S19 -0.0447751
MT2A metallothionein 2A -0.0438295
PFN1 profilin 1 -0.0438038
ACTG1 actin gamma 1 -0.040198
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0399758
RPS27 ribosomal protein S27 -0.0397513
RPLP1 ribosomal protein, large, P1 -0.0396037
GRAMD1B GRAM domain containing 1B -0.0394944
KTN1 kinectin 1 (kinesin receptor) -0.0391462
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0385653
FTL ferritin, light polypeptide -0.0372093
RPL37A ribosomal protein L37a -0.037148
RPL12 ribosomal protein L12 -0.0368028
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0367744
MCL1 myeloid cell leukemia 1 -0.0366776
EGR1 early growth response 1 -0.0365402
OSMR oncostatin M receptor -0.035511
RPS12 ribosomal protein S12 -0.0350058
RPL37 ribosomal protein L37 -0.0346646
RPL31 ribosomal protein L31 -0.0345821
RPS21 ribosomal protein S21 -0.0345256
THSD4 thrombospondin, type I, domain containing 4 -0.0342418
RPL19 ribosomal protein L19 -0.0330566
RPS27A ribosomal protein S27a -0.0314128
RPS29 ribosomal protein S29 -0.0297933
RPLP2 ribosomal protein, large, P2 -0.0294688
MYL12B myosin, light chain 12B, regulatory -0.0294321
EML4 echinoderm microtubule associated protein like 4 -0.0294069
RPL5 ribosomal protein L5 -0.0286341
RPL36 ribosomal protein L36 -0.0281094
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0280676
PDE10A phosphodiesterase 10A -0.0277952
AFF3 AF4/FMR2 family, member 3 -0.0276815
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0271888
TPT1 tumor protein, translationally-controlled 1 -0.0269456
RPL34 ribosomal protein L34 -0.0268684
BASP1 brain abundant, membrane attached signal protein 1 -0.0267731
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.026321
IGF1R insulin-like growth factor 1 receptor -0.0262123
RPLP0 ribosomal protein, large, P0 -0.0261952
RACK1 receptor for activated C kinase 1 -0.0258506
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0257124
RPS6 ribosomal protein S6 -0.0243616
RPL11 ribosomal protein L11 -0.0233031
POTEF POTE ankyrin domain family, member F -0.0232802
NCOA7 nuclear receptor coactivator 7 -0.0232236
TPM2 tropomyosin 2 (beta) -0.0231483
TFPI2 tissue factor pathway inhibitor 2 -0.0228935
HMGA2 high mobility group AT-hook 2 -0.022736
FMNL2 formin-like 2 -0.0224194
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.022271
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0217088
FNDC3B fibronectin type III domain containing 3B -0.0215254
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0215121
NAP1L1 nucleosome assembly protein 1-like 1 -0.0213334
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0212566
VCL vinculin -0.0211347
ATP5F1E ATP synthase F1 subunit epsilon -0.0210552
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0210261
RIMS2 regulating synaptic membrane exocytosis 2 -0.0210057
GNAS GNAS complex locus -0.0209831
CAVIN1 caveolae associated protein 1 -0.0209547
WWOX WW domain containing oxidoreductase -0.0208634
RPS10 ribosomal protein S10 -0.0208337
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0208057
RPL18 ribosomal protein L18 -0.0206506
TPM4 tropomyosin 4 -0.0206194
EGFR epidermal growth factor receptor -0.0205945
RPS4X ribosomal protein S4, X-linked -0.0205306
PRH1 proline-rich protein HaeIII subfamily 1 -0.0202282
RPS17 ribosomal protein S17 -0.0201617
ADAR adenosine deaminase, RNA-specific -0.0201445
KRT18 keratin 18, type I -0.0200708
USP34 ubiquitin specific peptidase 34 -0.019969
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0198955
ATXN1 ataxin 1 -0.0197073
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0195158
PKM pyruvate kinase, muscle -0.0192926
RPL32 ribosomal protein L32 -0.0191707
RPS16 ribosomal protein S16 -0.0191049
RNF213 ring finger protein 213 -0.0186768
RPL27 ribosomal protein L27 -0.0186469
RPL35 ribosomal protein L35 -0.0186458
RPL36A ribosomal protein L36a -0.0186229
DOCK5 dedicator of cytokinesis 5 -0.0185027
RPS24 ribosomal protein S24 -0.0182302
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0181026