Bosentan (hydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0743574
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0705693
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0694612
NAMPT nicotinamide phosphoribosyltransferase 0.040498
FXR1 fragile X mental retardation, autosomal homolog 1 0.035714
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0352036
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.033182
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0324304
HSPA8 heat shock 70kDa protein 8 0.0319439
MATR3 matrin 3 0.0288138
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.028473
RAD21 RAD21 homolog (S. pombe) 0.0276322
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0268664
MSMO1 methylsterol monooxygenase 1 0.0265966
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0233823
NCKAP1 NCK-associated protein 1 0.0230585
USP3 ubiquitin specific peptidase 3 0.0213809
ZNF292 zinc finger protein 292 0.0190772
ARRDC3 arrestin domain containing 3 0.018948
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.018548
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0184225
TOP2B topoisomerase (DNA) II beta 180kDa 0.0175075
PAPOLA poly(A) polymerase alpha 0.0173152
HMGB2 high mobility group box 2 0.0172508
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0167899
SSBP2 single-stranded DNA binding protein 2 0.0165393
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0164496
UBQLN1 ubiquilin 1 0.0156676
RYBP RING1 and YY1 binding protein 0.0155262
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.015496
ECT2 epithelial cell transforming 2 0.0151865
KDM3A lysine (K)-specific demethylase 3A 0.0151802
SMG7 SMG7 nonsense mediated mRNA decay factor 0.015178
FHIT fragile histidine triad 0.0149262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0144826
RPL4 ribosomal protein L4 0.0140803
TFG TRK-fused gene 0.014056
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0136313
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.013496
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.013447
CAMTA1 calmodulin binding transcription activator 1 0.013389
CDC73 cell division cycle 73 0.013178
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0131686
CCNL1 cyclin L1 0.0131511
GARS1 glycyl-tRNA synthetase 1 0.0130779
ASPH aspartate beta-hydroxylase 0.0128989
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.012895
NEK7 NIMA-related kinase 7 0.012585
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.012575
NPTN neuroplastin 0.0125716
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0125665
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0125557
CLINT1 clathrin interactor 1 0.012547
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0125277
PELI1 pellino E3 ubiquitin protein ligase 1 0.0122709
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0121548
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0120399
CPNE8 copine VIII 0.0119865
ATP13A3 ATPase type 13A3 0.0117422
LRRC1 leucine rich repeat containing 1 0.0117101
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.011678
FAR1 fatty acyl CoA reductase 1 0.011645
PPME1 protein phosphatase methylesterase 1 0.0116387
RPL3 ribosomal protein L3 0.0115735
ANXA5 annexin A5 0.011527
SERINC1 serine incorporator 1 0.0113923
CANX calnexin 0.0113738
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0111444
PTK2 protein tyrosine kinase 2 0.0108529
OLA1 Obg-like ATPase 1 0.0108101
NUP58 nucleoporin 58 0.0107884
AHR aryl hydrocarbon receptor 0.0107438
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0106076
RYK receptor-like tyrosine kinase 0.010587
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0105127
CD83 CD83 molecule 0.0104743
WDR43 WD repeat domain 43 0.0103321
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0102692
IL6ST interleukin 6 signal transducer 0.0101708
OSBPL9 oxysterol binding protein-like 9 0.0101483
DSPP dentin sialophosphoprotein 0.0100896
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0100772
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00996867
MSN moesin 0.0099639
YTHDC1 YTH domain containing 1 0.00995221
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0099504
EIF4H eukaryotic translation initiation factor 4H 0.00985586
RAD23B RAD23 homolog B (S. cerevisiae) 0.00983503
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00981201
AGFG1 ArfGAP with FG repeats 1 0.00977961
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00972405
TMEM39A transmembrane protein 39A 0.00966698
IPO7 importin 7 0.00949952
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00944291
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00941153
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.00939734
METAP1 methionyl aminopeptidase 1 0.00934042
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.00914032
DPEP2 dipeptidase 2 0.00913565
ARGLU1 arginine and glutamate rich 1 0.00909482

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.291375
TMSB10 thymosin beta 10 -0.196291
PTMA prothymosin, alpha -0.186907
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163887
ACTG1 actin gamma 1 -0.152493
NDRG1 N-myc downstream regulated 1 -0.132535
S100A6 S100 calcium binding protein A6 -0.105289
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.104829
MT2A metallothionein 2A -0.0970237
POTEF POTE ankyrin domain family, member F -0.0727386
LAMB3 laminin, beta 3 -0.0697394
IFI27 interferon, alpha-inducible protein 27 -0.0687486
RPL35A ribosomal protein L35a -0.0680488
HMGA1 high mobility group AT-hook 1 -0.0676542
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0676283
RPLP2 ribosomal protein, large, P2 -0.0670414
RPS19 ribosomal protein S19 -0.0667243
FBXO32 F-box protein 32 -0.0642873
UBC ubiquitin C -0.0620323
EIF1 eukaryotic translation initiation factor 1 -0.0619561
RPS3 ribosomal protein S3 -0.0617657
ZFP36L1 ZFP36 ring finger protein-like 1 -0.06013
IGFBP3 insulin-like growth factor binding protein 3 -0.0585434
RPS8 ribosomal protein S8 -0.056376
IFITM1 interferon induced transmembrane protein 1 -0.0550603
LIMCH1 LIM and calponin homology domains 1 -0.054906
IFITM3 interferon induced transmembrane protein 3 -0.0533233
KRT7 keratin 7, type II -0.0524107
RPLP1 ribosomal protein, large, P1 -0.0507197
ISG15 ISG15 ubiquitin-like modifier -0.0506288
ALCAM activated leukocyte cell adhesion molecule -0.0498813
RPS29 ribosomal protein S29 -0.0493478
IFI6 interferon, alpha-inducible protein 6 -0.0482883
TPT1 tumor protein, translationally-controlled 1 -0.0479858
HLA-A major histocompatibility complex, class I, A -0.0458882
CSTB cystatin B (stefin B) -0.0453368
LMNA lamin A/C -0.044904
S100A9 S100 calcium binding protein A9 -0.0445333
BASP1 brain abundant, membrane attached signal protein 1 -0.0443809
LPP LIM domain containing preferred translocation partner in lipoma -0.0440063
TPM4 tropomyosin 4 -0.0437723
SLC38A1 solute carrier family 38, member 1 -0.0434255
RPS13 ribosomal protein S13 -0.0431451
EXT1 exostosin glycosyltransferase 1 -0.0417767
RPL37A ribosomal protein L37a -0.0414723
RPL8 ribosomal protein L8 -0.0412291
LMO7 LIM domain 7 -0.0405926
TM4SF1 transmembrane 4 L six family member 1 -0.0405219
RAB7A RAB7A, member RAS oncogene family -0.0404679
RACK1 receptor for activated C kinase 1 -0.0402055
SH3KBP1 SH3-domain kinase binding protein 1 -0.0397571
ERBIN erbb2 interacting protein -0.039596
SOX4 SRY (sex determining region Y)-box 4 -0.0394827
PKM pyruvate kinase, muscle -0.0394428
ITCH itchy E3 ubiquitin protein ligase -0.0393645
SAMD4A sterile alpha motif domain containing 4A -0.039135
VIM vimentin -0.039016
RPL34 ribosomal protein L34 -0.038779
ZSWIM6 zinc finger, SWIM-type containing 6 -0.038692
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384741
RPS27 ribosomal protein S27 -0.038196
GNAS GNAS complex locus -0.038065
RPS14 ribosomal protein S14 -0.0380537
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0379505
ACBD3 acyl-CoA binding domain containing 3 -0.037609
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0375447
NPEPPS aminopeptidase puromycin sensitive -0.0374808
FLNB filamin B, beta -0.0373836
RPS6 ribosomal protein S6 -0.0365312
TMSB4X thymosin beta 4, X-linked -0.0363495
TPI1 triosephosphate isomerase 1 -0.0359066
G0S2 G0/G1 switch 2 -0.0358563
GOLGA4 golgin A4 -0.0354785
RPL19 ribosomal protein L19 -0.0354196
HLA-B major histocompatibility complex, class I, B -0.0352241
KDM5B lysine (K)-specific demethylase 5B -0.034071
UBE2H ubiquitin-conjugating enzyme E2H -0.033844
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0338134
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0337202
RBM25 RNA binding motif protein 25 -0.0336727
RPS27A ribosomal protein S27a -0.0334664
ANXA2 annexin A2 -0.0334013
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0333667
RPL9 ribosomal protein L9 -0.03318
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0331604
S100A10 S100 calcium binding protein A10 -0.033122
WASF2 WAS protein family, member 2 -0.0328349
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0321042
ENO2 enolase 2 (gamma, neuronal) -0.031629
RPL15 ribosomal protein L15 -0.0316077
RPL12 ribosomal protein L12 -0.0314742
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0311488
RPL28 ribosomal protein L28 -0.0310205
RPL31 ribosomal protein L31 -0.0309337
RPL37 ribosomal protein L37 -0.0308845
MYO1E myosin IE -0.0308596
CD63 CD63 molecule -0.0308323
RPL36 ribosomal protein L36 -0.0304252
RPL18 ribosomal protein L18 -0.0302359
COPA coatomer protein complex, subunit alpha -0.0301621