| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.0533236 |
| ASPH | aspartate beta-hydroxylase | 0.0520391 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0470249 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0447714 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0367828 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0353914 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0338183 |
| LSAMP | limbic system-associated membrane protein | 0.033222 |
| RPL23 | ribosomal protein L23 | 0.0299208 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0298806 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.028595 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.027501 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0271551 |
| PDE7B | phosphodiesterase 7B | 0.0271283 |
| OGA | O-GlcNAcase | 0.0250897 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.024699 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0239063 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0230794 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0220594 |
| SPAG9 | sperm associated antigen 9 | 0.0217698 |
| CENPF | centromere protein F, 350/400kDa | 0.0217239 |
| SET | SET nuclear proto-oncogene | 0.0215756 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0213505 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0213401 |
| CTBP2 | C-terminal binding protein 2 | 0.0194042 |
| DIAPH3 | diaphanous-related formin 3 | 0.0193878 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0192461 |
| ZNF292 | zinc finger protein 292 | 0.0189975 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0189575 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0187115 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.018665 |
| MYOF | myoferlin | 0.0185098 |
| WDR43 | WD repeat domain 43 | 0.0181475 |
| FAM13A | family with sequence similarity 13, member A | 0.0178936 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0177089 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0170971 |
| METTL15 | methyltransferase like 15 | 0.0170842 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0166663 |
| RBM25 | RNA binding motif protein 25 | 0.0165323 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0162752 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0161917 |
| RPL37A | ribosomal protein L37a | 0.01611 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0160164 |
| NUP58 | nucleoporin 58 | 0.0159798 |
| PRELID2 | PRELI domain containing 2 | 0.0158276 |
| TMSB10 | thymosin beta 10 | 0.0154239 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0152164 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0149563 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0148456 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0148174 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0146699 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0145247 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0145097 |
| PNN | pinin, desmosome associated protein | 0.0141756 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0140922 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0139863 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0139153 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.013838 |
| NCKAP1 | NCK-associated protein 1 | 0.0138372 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0137282 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0136218 |
| RPL21 | ribosomal protein L21 | 0.0135993 |
| MKI67 | marker of proliferation Ki-67 | 0.0134403 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0133686 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0133462 |
| RPS7 | ribosomal protein S7 | 0.0132832 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0132727 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0130872 |
| ZNF638 | zinc finger protein 638 | 0.0130277 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0129436 |
| RPS19 | ribosomal protein S19 | 0.0128654 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0126739 |
| MATR3 | matrin 3 | 0.0125974 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0125428 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.012524 |
| GOLGA4 | golgin A4 | 0.012389 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0122049 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0121273 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0120472 |
| TPR | translocated promoter region, nuclear basket protein | 0.011899 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0118115 |
| CDC73 | cell division cycle 73 | 0.0117398 |
| RPS12 | ribosomal protein S12 | 0.0116938 |
| ANO6 | anoctamin 6 | 0.0114802 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0114792 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0114765 |
| TOP1 | topoisomerase (DNA) I | 0.0114712 |
| CEP72 | centrosomal protein 72kDa | 0.011457 |
| TPM3 | tropomyosin 3 | 0.011382 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0113425 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0113009 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0112835 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0112705 |
| RPL36 | ribosomal protein L36 | 0.0111971 |
| SRP54 | signal recognition particle 54kDa | 0.0108956 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.010879 |
| CKAP5 | cytoskeleton associated protein 5 | 0.010771 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0106802 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0106279 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0104947 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.361836 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.360237 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.308461 |
| VIM | vimentin | -0.128447 |
| GDA | guanine deaminase | -0.0953448 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0869026 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0826607 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0807237 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0790825 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.076055 |
| CDH13 | cadherin 13 | -0.0756459 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0726994 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0694133 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0637415 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0620234 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0619319 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0556849 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0543789 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0531996 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0530582 |
| STC1 | stanniocalcin 1 | -0.0522172 |
| UBC | ubiquitin C | -0.0516909 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.050976 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0492119 |
| AUTS2 | autism susceptibility candidate 2 | -0.047536 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0450889 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0444214 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0438691 |
| RPS23 | ribosomal protein S23 | -0.0432144 |
| NDRG1 | N-myc downstream regulated 1 | -0.0428713 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0427954 |
| HLA-B | major histocompatibility complex, class I, B | -0.0421884 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0401899 |
| S100A10 | S100 calcium binding protein A10 | -0.0398156 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0396767 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0394832 |
| RPS24 | ribosomal protein S24 | -0.0394266 |
| CD44 | CD44 molecule (Indian blood group) | -0.0394018 |
| TPM4 | tropomyosin 4 | -0.0378702 |
| INHBA | inhibin, beta A | -0.0378453 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0376902 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0372747 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0372671 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0372412 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0372125 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0370484 |
| MCL1 | myeloid cell leukemia 1 | -0.0370277 |
| VCL | vinculin | -0.0369952 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0361398 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.03529 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.034298 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0342639 |
| SMAD2 | SMAD family member 2 | -0.0342299 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0338583 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0337518 |
| OSMR | oncostatin M receptor | -0.0326377 |
| PYGL | phosphorylase, glycogen, liver | -0.0326149 |
| DST | dystonin | -0.0325561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0323097 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0321743 |
| RPLP0 | ribosomal protein, large, P0 | -0.031713 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.031625 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0315803 |
| LDHA | lactate dehydrogenase A | -0.031183 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0310585 |
| ACTG1 | actin gamma 1 | -0.030849 |
| CANX | calnexin | -0.0307049 |
| RPS6 | ribosomal protein S6 | -0.0306093 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0302634 |
| HLA-A | major histocompatibility complex, class I, A | -0.0301922 |
| ANXA2 | annexin A2 | -0.0301778 |
| JMJD1C | jumonji domain containing 1C | -0.0300611 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0299958 |
| KYNU | kynureninase | -0.0296751 |
| EXT1 | exostosin glycosyltransferase 1 | -0.029652 |
| PTMA | prothymosin, alpha | -0.0296158 |
| RPLP1 | ribosomal protein, large, P1 | -0.0293732 |
| CTSL | cathepsin L | -0.0292014 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0291733 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0289547 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286635 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0286155 |
| ABLIM1 | actin binding LIM protein 1 | -0.0285131 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0284189 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0283871 |
| FMNL2 | formin-like 2 | -0.0277989 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0277319 |
| S100A6 | S100 calcium binding protein A6 | -0.027658 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0268172 |
| RPL34 | ribosomal protein L34 | -0.0262679 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0257789 |
| ASTN2 | astrotactin 2 | -0.0256231 |
| NTN4 | netrin 4 | -0.0251683 |
| GNAS | GNAS complex locus | -0.0250584 |
| FOXC1 | forkhead box C1 | -0.0247269 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0247234 |
| ATXN1 | ataxin 1 | -0.0246462 |
| MFF | mitochondrial fission factor | -0.0246024 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0244471 |
| RHOA | ras homolog family member A | -0.024328 |
