Bosentan (hydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

145 genes differentially expressed following the Bosentan (hydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.127081
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.125347
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.12092
UBA6 ubiquitin-like modifier activating enzyme 6 0.120658
TRIO trio Rho guanine nucleotide exchange factor 0.119908
AKAP12 A kinase (PRKA) anchor protein 12 0.108322
RPL23 ribosomal protein L23 0.101969
GRB10 growth factor receptor-bound protein 10 0.101204
KYNU kynureninase 0.0955707
TRA2A transformer 2 alpha homolog (Drosophila) 0.0910093
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0887038
NAMPT nicotinamide phosphoribosyltransferase 0.0818779
NF1 neurofibromin 1 0.0809315
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0737117
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0718002
EZR ezrin 0.0701003
CANX calnexin 0.0683705
RPLP1 ribosomal protein, large, P1 0.0679373
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0672982
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0672322
NKD1 naked cuticle homolog 1 (Drosophila) 0.0661188
CCNI cyclin I 0.0638249
S100A9 S100 calcium binding protein A9 0.0636921
THSD4 thrombospondin, type I, domain containing 4 0.0635864
UBC ubiquitin C 0.0632262
NAP1L1 nucleosome assembly protein 1-like 1 0.0630133
RPS12 ribosomal protein S12 0.0623258
MAP1B microtubule-associated protein 1B 0.0622808
GPHN gephyrin 0.0618997
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0602351
PRELID2 PRELI domain containing 2 0.0594989
RBM39 RNA binding motif protein 39 0.0585868
RPL11 ribosomal protein L11 0.057543
ASPH aspartate beta-hydroxylase 0.0541084
GSK3B glycogen synthase kinase 3 beta 0.0535737
TOR1AIP2 torsin A interacting protein 2 0.0534424
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0501326
NAV1 neuron navigator 1 0.0499116
LOXL2 lysyl oxidase-like 2 0.0488397
ADAM10 ADAM metallopeptidase domain 10 0.0481195
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.048077
ENO1 enolase 1, (alpha) 0.0434199
ZMYND8 zinc finger, MYND-type containing 8 0.0417957
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.040472
BIRC6 baculoviral IAP repeat containing 6 0.0403468
HMGA2 high mobility group AT-hook 2 0.03884
FAM13A family with sequence similarity 13, member A 0.0362218
ELL2 elongation factor, RNA polymerase II, 2 0.0340414
RPS8 ribosomal protein S8 0.0337605
MYOF myoferlin 0.0328735
RPS6 ribosomal protein S6 0.0312201
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.030205
SETD5 SET domain containing 5 0.0295004
LMO7 LIM domain 7 0.0285706
RICTOR RPTOR independent companion of MTOR, complex 2 0.0264148
B2M beta-2-microglobulin 0.0255882
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0255325
RPS3 ribosomal protein S3 0.0250001
EPS8 epidermal growth factor receptor pathway substrate 8 0.0249312
OSMR oncostatin M receptor 0.0240478
FNDC3B fibronectin type III domain containing 3B 0.0237119
SMYD3 SET and MYND domain containing 3 0.0224548
SBF2 SET binding factor 2 0.022327
RPS24 ribosomal protein S24 0.021767
RPS25 ribosomal protein S25 0.0194584
RPS13 ribosomal protein S13 0.0185747
RPL36 ribosomal protein L36 0.0176998
STC1 stanniocalcin 1 0.0167843
TXNRD1 thioredoxin reductase 1 0.0159299
LOC102724023 ES1 protein homolog, mitochondrial 0.0158755
JMJD1C jumonji domain containing 1C 0.0153292
KMT2C lysine (K)-specific methyltransferase 2C 0.014533
MAP4 microtubule-associated protein 4 0.0139316
TMSB10 thymosin beta 10 0.0127888
AHNAK AHNAK nucleoprotein 0.0123212
FLNB filamin B, beta 0.0118211
THOC2 THO complex 2 0.0116905
ANXA2 annexin A2 0.01121
SRPK2 SRSF protein kinase 2 0.0107115
MAML3 mastermind-like 3 (Drosophila) 0.0102129
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00940988
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00632926
IGFBP3 insulin-like growth factor binding protein 3 0.00478839
USP34 ubiquitin specific peptidase 34 0.00472929
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.00437085
RPLP2 ribosomal protein, large, P2 0.0042605
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00232277
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.00206054
MYO1E myosin IE 0.0019146
LPP LIM domain containing preferred translocation partner in lipoma 0.00180019

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.417105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.36483
NDRG1 N-myc downstream regulated 1 -0.226091
VIM vimentin -0.161363
GPC6 glypican 6 -0.160495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.127418
IGFBP5 insulin-like growth factor binding protein 5 -0.0965115
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0919367
LDHA lactate dehydrogenase A -0.0904717
FTL ferritin, light polypeptide -0.0877661
PTMA prothymosin, alpha -0.0864808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0815201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0770698
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0761494
SPAG9 sperm associated antigen 9 -0.0691815
MT2A metallothionein 2A -0.0667698
RPL12 ribosomal protein L12 -0.0657106
NPAS2 neuronal PAS domain protein 2 -0.0586814
KMT2E lysine (K)-specific methyltransferase 2E -0.0585778
PKM pyruvate kinase, muscle -0.0539028
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0519415
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0483157
EGFR epidermal growth factor receptor -0.0470028
PGK1 phosphoglycerate kinase 1 -0.0469682
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0464208
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0463477
PARD3 par-3 family cell polarity regulator -0.0452415
DSCAM Down syndrome cell adhesion molecule -0.0444417
PTK2 protein tyrosine kinase 2 -0.0440398
CHD9 chromodomain helicase DNA binding protein 9 -0.0421414
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0413215
KDM5B lysine (K)-specific demethylase 5B -0.0400105
PDE10A phosphodiesterase 10A -0.0386439
ZFAND3 zinc finger, AN1-type domain 3 -0.0314635
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.030817
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0301313
FTH1 ferritin, heavy polypeptide 1 -0.0286887
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0277586
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0275635
MEF2A myocyte enhancer factor 2A -0.0262163
ACTG1 actin gamma 1 -0.0240496
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0223768
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0182315
PRRC2C proline-rich coiled-coil 2C -0.0180125
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0160814
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0134745
MON2 MON2 homolog (S. cerevisiae) -0.0119981
SLC38A1 solute carrier family 38, member 1 -0.00977498
HLA-B major histocompatibility complex, class I, B -0.00955804
PDE4D phosphodiesterase 4D, cAMP-specific -0.00876686
RPL35A ribosomal protein L35a -0.0084112
OGA O-GlcNAcase -0.00777176
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00641065
TPT1 tumor protein, translationally-controlled 1 -0.00179568
PDLIM5 PDZ and LIM domain 5 -0.00115649