| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.118489 |
| ITGAV | integrin, alpha V | 0.072286 |
| SPAG9 | sperm associated antigen 9 | 0.0687694 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.065179 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0602389 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0515565 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0491296 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0467625 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0421588 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0418655 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0416805 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0403524 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0385859 |
| TOP1 | topoisomerase (DNA) I | 0.0385334 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0380348 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0376103 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0375088 |
| TUT4 | terminal uridylyl transferase 4 | 0.0362365 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0355202 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0352777 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0340207 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0335964 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.033171 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0329055 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0328459 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0327692 |
| ITSN2 | intersectin 2 | 0.0325947 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0325835 |
| COG5 | component of oligomeric golgi complex 5 | 0.0324133 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0321014 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0319042 |
| TJP1 | tight junction protein 1 | 0.0318451 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0314483 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0313627 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0310902 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0309612 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0309438 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0306222 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0305797 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0305238 |
| MED13L | mediator complex subunit 13-like | 0.0304301 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0304284 |
| MPG | N-methylpurine-DNA glycosylase | 0.0299605 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0299259 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0297726 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0287087 |
| SRP54 | signal recognition particle 54kDa | 0.0284584 |
| TLK2 | tousled-like kinase 2 | 0.0284046 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0280598 |
| NEK7 | NIMA-related kinase 7 | 0.0276792 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0276179 |
| NCKAP1 | NCK-associated protein 1 | 0.0276069 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0275826 |
| DSPP | dentin sialophosphoprotein | 0.0275482 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0275444 |
| PDS5B | PDS5 cohesin associated factor B | 0.0274729 |
| USP34 | ubiquitin specific peptidase 34 | 0.0274197 |
| SGO2 | shugoshin 2 | 0.027321 |
| CS | citrate synthase | 0.0271363 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0271135 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0270227 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0270171 |
| ITM2B | integral membrane protein 2B | 0.0269083 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0267604 |
| FBXO11 | F-box protein 11 | 0.0267579 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0265619 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0264135 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0263944 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0263635 |
| CCNY | cyclin Y | 0.0263251 |
| CCN2 | cellular communication network factor 2 | 0.0260898 |
| UTRN | utrophin | 0.0260765 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0260406 |
| CENPF | centromere protein F, 350/400kDa | 0.0260191 |
| GOLM2 | golgi membrane protein 2 | 0.0260185 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0258779 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0258247 |
| BPTF | bromodomain PHD finger transcription factor | 0.0257319 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0256165 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0255881 |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.0255766 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | 0.0254975 |
| RLF | rearranged L-myc fusion | 0.0252588 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0251519 |
| USP33 | ubiquitin specific peptidase 33 | 0.025103 |
| ENAH | enabled homolog (Drosophila) | 0.0250827 |
| INTS6 | integrator complex subunit 6 | 0.0250459 |
| GPC4 | glypican 4 | 0.0249398 |
| TENM2 | teneurin transmembrane protein 2 | 0.0248253 |
| THOC2 | THO complex 2 | 0.0247397 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0246937 |
| WDR43 | WD repeat domain 43 | 0.0245594 |
| RPS6 | ribosomal protein S6 | 0.0243859 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0243258 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0242488 |
| PAPOLA | poly(A) polymerase alpha | 0.0241957 |
| ATL2 | atlastin GTPase 2 | 0.0241855 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0241586 |
| TMEM87A | transmembrane protein 87A | 0.0237204 |
| CANX | calnexin | 0.0236494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.150977 |
| VIM | vimentin | -0.144763 |
| PEG10 | paternally expressed 10 | -0.106507 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.102733 |
| GPC3 | glypican 3 | -0.0943692 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0901474 |
| THBS1 | thrombospondin 1 | -0.0703607 |
| ACTG1 | actin gamma 1 | -0.0666531 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0657623 |
| MEIS2 | Meis homeobox 2 | -0.0642927 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0642093 |
| TMSB10 | thymosin beta 10 | -0.0628631 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0561487 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.054915 |
| EMP1 | epithelial membrane protein 1 | -0.0546067 |
| RPL19 | ribosomal protein L19 | -0.0524971 |
| RPS16 | ribosomal protein S16 | -0.0524701 |
| CADM2 | cell adhesion molecule 2 | -0.051539 |
| RPL23 | ribosomal protein L23 | -0.0509995 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0480519 |
| RPS19 | ribosomal protein S19 | -0.0475738 |
| ACTN4 | actinin, alpha 4 | -0.0451976 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0448565 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | -0.0439141 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0430402 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0427884 |
| RPLP1 | ribosomal protein, large, P1 | -0.041571 |
| H1-0 | H1.0 linker histone | -0.0410856 |
| COL5A2 | collagen, type V, alpha 2 | -0.0410767 |
| UBC | ubiquitin C | -0.0409542 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0408094 |
| RPL7 | ribosomal protein L7 | -0.0407267 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0406244 |
| PFN1 | profilin 1 | -0.0400941 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0391918 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.037931 |
| FOXP2 | forkhead box P2 | -0.0366578 |
| SHROOM3 | shroom family member 3 | -0.0361243 |
| HDAC9 | histone deacetylase 9 | -0.0361238 |
| GNAS | GNAS complex locus | -0.0359706 |
| RPL18 | ribosomal protein L18 | -0.0355172 |
| AHNAK | AHNAK nucleoprotein | -0.0352353 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0347613 |
| RPL12 | ribosomal protein L12 | -0.0346178 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0344165 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0340429 |
| RPL34 | ribosomal protein L34 | -0.0330429 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0328936 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0327619 |
| RPL32 | ribosomal protein L32 | -0.0327406 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0325855 |
| RPL36A | ribosomal protein L36a | -0.032343 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.032231 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0321292 |
| FUS | FUS RNA binding protein | -0.0319091 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0316994 |
| TENM3 | teneurin transmembrane protein 3 | -0.0315999 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0315577 |
| RPS27A | ribosomal protein S27a | -0.0312849 |
| MYL12B | myosin, light chain 12B, regulatory | -0.03127 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0312464 |
| CALR | calreticulin | -0.031002 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0307368 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0306656 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0299837 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0298681 |
| RPLP2 | ribosomal protein, large, P2 | -0.0294965 |
| RPS4X | ribosomal protein S4, X-linked | -0.0294376 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0291381 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0284493 |
| RPS3 | ribosomal protein S3 | -0.0283937 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0281336 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.0281306 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0280482 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0276937 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0275983 |
| YBX1 | Y box binding protein 1 | -0.0274477 |
| DOCK5 | dedicator of cytokinesis 5 | -0.027137 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0269842 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0269838 |
| RPL37A | ribosomal protein L37a | -0.0269424 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0269201 |
| COX6C | cytochrome c oxidase subunit VIc | -0.0264675 |
| RPL35 | ribosomal protein L35 | -0.0263161 |
| METTL16 | methyltransferase like 16 | -0.0263001 |
| LCA5 | Leber congenital amaurosis 5 | -0.0256739 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0255985 |
| CBX3 | chromobox homolog 3 | -0.0254427 |
| RFX7 | regulatory factor X, 7 | -0.0253498 |
| RPS13 | ribosomal protein S13 | -0.0253417 |
| VGLL3 | vestigial-like family member 3 | -0.025215 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | -0.0251797 |
| ZNF608 | zinc finger protein 608 | -0.0250522 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.024919 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0248579 |
| CALU | calumenin | -0.0247494 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0244345 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0243939 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0243357 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0239802 |
