| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.210866 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.132553 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.12471 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.112706 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0956551 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0940269 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.090606 |
| PTMA | prothymosin, alpha | 0.0760303 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0740497 |
| FBL | fibrillarin | 0.0703275 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0663638 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0661206 |
| OGA | O-GlcNAcase | 0.063499 |
| ZNF292 | zinc finger protein 292 | 0.0615605 |
| ENO1 | enolase 1, (alpha) | 0.0587069 |
| FMNL2 | formin-like 2 | 0.0575226 |
| SPAG9 | sperm associated antigen 9 | 0.0573668 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0510606 |
| PRELID2 | PRELI domain containing 2 | 0.0500192 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0493198 |
| ATP13A3 | ATPase type 13A3 | 0.0476931 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0475665 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0450694 |
| GOLGA4 | golgin A4 | 0.0448008 |
| NAV2 | neuron navigator 2 | 0.0424034 |
| LDHA | lactate dehydrogenase A | 0.0418393 |
| SNX14 | sorting nexin 14 | 0.0408945 |
| CANX | calnexin | 0.0403233 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0401493 |
| PGK1 | phosphoglycerate kinase 1 | 0.039635 |
| AFAP1 | actin filament associated protein 1 | 0.0385227 |
| AHNAK | AHNAK nucleoprotein | 0.0384952 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0382917 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0381724 |
| PDE10A | phosphodiesterase 10A | 0.0370682 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0370091 |
| TXNRD1 | thioredoxin reductase 1 | 0.0369494 |
| TFRC | transferrin receptor | 0.0363663 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.036339 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0362238 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0356208 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0354543 |
| CDK19 | cyclin-dependent kinase 19 | 0.0352314 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0351808 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0348936 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0334618 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0331921 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0331173 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0329757 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0326468 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0319903 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0319022 |
| XPO1 | exportin 1 | 0.0316229 |
| SUCO | SUN domain containing ossification factor | 0.0313418 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.031255 |
| DST | dystonin | 0.0307967 |
| USP3 | ubiquitin specific peptidase 3 | 0.0304454 |
| TMEM123 | transmembrane protein 123 | 0.0300618 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0294991 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0292468 |
| ANLN | anillin, actin binding protein | 0.0291953 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0289866 |
| ARRDC3 | arrestin domain containing 3 | 0.0284936 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0284803 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0282807 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0281932 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0279438 |
| SET | SET nuclear proto-oncogene | 0.0279363 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0278236 |
| SERINC1 | serine incorporator 1 | 0.0276745 |
| TPD52 | tumor protein D52 | 0.0276164 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0275205 |
| MED13L | mediator complex subunit 13-like | 0.0269921 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.026762 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0265268 |
| RLF | rearranged L-myc fusion | 0.0264086 |
| MATR3 | matrin 3 | 0.0263081 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0262448 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0261252 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0257674 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0257479 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0257468 |
| YAP1 | Yes-associated protein 1 | 0.025564 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0255012 |
| PHIP | pleckstrin homology domain interacting protein | 0.0251725 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | 0.0251213 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0247663 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0246101 |
| TFG | TRK-fused gene | 0.0246047 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.023953 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0236736 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0235653 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0234521 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0232097 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0229831 |
| BBX | bobby sox homolog (Drosophila) | 0.0228809 |
| AFDN | afadin, adherens junction formation factor | 0.0228621 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0228422 |
| YEATS2 | YEATS domain containing 2 | 0.0227179 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0225053 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.318587 |
| ZFP36 | ZFP36 ring finger protein | -0.135539 |
| EGR1 | early growth response 1 | -0.0979932 |
| SAMD4B | sterile alpha motif domain containing 4B | -0.0932482 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0922735 |
| ACTN4 | actinin, alpha 4 | -0.0907314 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.0873416 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | -0.0741816 |
| VIM | vimentin | -0.0690941 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.062384 |
| CD44 | CD44 molecule (Indian blood group) | -0.0591957 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0570367 |
| TPM1 | tropomyosin 1 (alpha) | -0.0565028 |
| EGFR | epidermal growth factor receptor | -0.0482615 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0464504 |
| NUP98 | nucleoporin 98kDa | -0.0455554 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0444492 |
| VMP1 | vacuole membrane protein 1 | -0.0437728 |
| FHL2 | four and a half LIM domains 2 | -0.0427605 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0410399 |
| INTS6 | integrator complex subunit 6 | -0.0408854 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0394892 |
| ZNF780B | zinc finger protein 780B | -0.039483 |
| RPS16 | ribosomal protein S16 | -0.0387848 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0378838 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.037694 |
| NABP1 | nucleic acid binding protein 1 | -0.0362976 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0361256 |
| OSMR | oncostatin M receptor | -0.035859 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0353859 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0348855 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0348375 |
| PHF14 | PHD finger protein 14 | -0.0343462 |
| MYO1E | myosin IE | -0.0340619 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0331553 |
| ACTG1 | actin gamma 1 | -0.0329249 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0320308 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0314941 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0311929 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0310133 |
| ITGB5 | integrin, beta 5 | -0.0309006 |
| TMSB10 | thymosin beta 10 | -0.0299856 |
| LOC112694756 | uncharaterized LOC112694756 | -0.029685 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0296709 |
| MCL1 | myeloid cell leukemia 1 | -0.0290608 |
| FOSL1 | FOS-like antigen 1 | -0.0287621 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0285493 |
| BMP6 | bone morphogenetic protein 6 | -0.0275398 |
| MOSMO | modulator of smoothened | -0.0274899 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0272147 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0267641 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0265557 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0265443 |
| BRD2 | bromodomain containing 2 | -0.0265341 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0262878 |
| RPL35A | ribosomal protein L35a | -0.0261993 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.0260991 |
| RTN4 | reticulon 4 | -0.0260205 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0259117 |
| MAP3K10 | mitogen-activated protein kinase kinase kinase 10 | -0.0255423 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0254963 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0253883 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0253631 |
| RASAL2 | RAS protein activator like 2 | -0.025247 |
| EHBP1 | EH domain binding protein 1 | -0.0249847 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0249728 |
| RSU1 | Ras suppressor protein 1 | -0.024938 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0246775 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0244446 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0243551 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0238277 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023662 |
| TAPBP | TAP binding protein (tapasin) | -0.023473 |
| HDAC9 | histone deacetylase 9 | -0.0233034 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0231771 |
| EPAS1 | endothelial PAS domain protein 1 | -0.022714 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0226819 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0225893 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0225735 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0224699 |
| MAP1B | microtubule-associated protein 1B | -0.0223551 |
| ITGAV | integrin, alpha V | -0.0218758 |
| ZNF644 | zinc finger protein 644 | -0.0216865 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0212788 |
| CCN2 | cellular communication network factor 2 | -0.0212542 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0210213 |
| TRIM66 | tripartite motif containing 66 | -0.0209084 |
| BCL2L1 | BCL2-like 1 | -0.0208686 |
| MYADM | myeloid-associated differentiation marker | -0.0208179 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0207552 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.0204707 |
| ATG7 | autophagy related 7 | -0.0202446 |
| RPL28 | ribosomal protein L28 | -0.0201756 |
| DSCAM | Down syndrome cell adhesion molecule | -0.020094 |
| AXL | AXL receptor tyrosine kinase | -0.0197807 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0197675 |
| TMEM41B | transmembrane protein 41B | -0.0196996 |
| FAM120B | family with sequence similarity 120B | -0.0195249 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0191666 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0191396 |
