| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0618979 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0592597 |
| OGA | O-GlcNAcase | 0.0547804 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0532153 |
| TSC22D2 | TSC22 domain family, member 2 | 0.052191 |
| CCNL1 | cyclin L1 | 0.0470987 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0457937 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0457326 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.044633 |
| XPO1 | exportin 1 | 0.0436429 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0391333 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0369499 |
| ECT2 | epithelial cell transforming 2 | 0.0356375 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0353839 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0349571 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0341187 |
| KRT17 | keratin 17, type I | 0.0339279 |
| ARRDC3 | arrestin domain containing 3 | 0.0337728 |
| ANLN | anillin, actin binding protein | 0.0332434 |
| TFG | TRK-fused gene | 0.0322666 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0321918 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0318986 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0318779 |
| RBM39 | RNA binding motif protein 39 | 0.03182 |
| ATP13A3 | ATPase type 13A3 | 0.0318161 |
| MATR3 | matrin 3 | 0.0315406 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0312938 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.030598 |
| PTK2 | protein tyrosine kinase 2 | 0.0297086 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0295372 |
| NAV2 | neuron navigator 2 | 0.0294688 |
| RIOK3 | RIO kinase 3 | 0.0294103 |
| RLF | rearranged L-myc fusion | 0.0291582 |
| ZNF292 | zinc finger protein 292 | 0.0290087 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.028692 |
| CLINT1 | clathrin interactor 1 | 0.0285794 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.028288 |
| GOLGA4 | golgin A4 | 0.0281606 |
| RYK | receptor-like tyrosine kinase | 0.0278932 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0277594 |
| CALR | calreticulin | 0.0272595 |
| TMEM123 | transmembrane protein 123 | 0.0271868 |
| LDHA | lactate dehydrogenase A | 0.0269039 |
| CD47 | CD47 molecule | 0.0267903 |
| LRRC1 | leucine rich repeat containing 1 | 0.0267045 |
| FNBP1L | formin binding protein 1-like | 0.0266346 |
| USP3 | ubiquitin specific peptidase 3 | 0.0260254 |
| TMF1 | TATA element modulatory factor 1 | 0.025898 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0257006 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0256657 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0256097 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0255282 |
| NEK7 | NIMA-related kinase 7 | 0.0254069 |
| PGK1 | phosphoglycerate kinase 1 | 0.0251669 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0251485 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0249754 |
| MIS18BP1 | MIS18 binding protein 1 | 0.024872 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0246698 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0244356 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0243157 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0242033 |
| NCKAP1 | NCK-associated protein 1 | 0.0241662 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0240505 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0238853 |
| TRIM33 | tripartite motif containing 33 | 0.0237427 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0236 |
| HMGB2 | high mobility group box 2 | 0.0235675 |
| UBQLN1 | ubiquilin 1 | 0.0235522 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0232047 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0230601 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.022847 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0228143 |
| YTHDC1 | YTH domain containing 1 | 0.0226639 |
| MTF2 | metal response element binding transcription factor 2 | 0.022642 |
| MED13L | mediator complex subunit 13-like | 0.0222923 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0222181 |
| PDS5B | PDS5 cohesin associated factor B | 0.0221131 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0220224 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.021694 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0216283 |
| DENND4C | DENN/MADD domain containing 4C | 0.0212198 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0212137 |
| RNF145 | ring finger protein 145 | 0.0211075 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0209907 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0207921 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0205378 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0205307 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.020451 |
| ATL2 | atlastin GTPase 2 | 0.0203962 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0203748 |
| SERINC1 | serine incorporator 1 | 0.0201798 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0201683 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0197142 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0196838 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.01951 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0194532 |
| CENPF | centromere protein F, 350/400kDa | 0.0193954 |
| SNX4 | sorting nexin 4 | 0.0192309 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.0191325 |
| CANX | calnexin | 0.0190075 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.14558 |
| INTS6 | integrator complex subunit 6 | -0.116834 |
| MUC4 | mucin 4, cell surface associated | -0.102826 |
| LAMA4 | laminin, alpha 4 | -0.0901416 |
| HMGA1 | high mobility group AT-hook 1 | -0.0885309 |
| MUC16 | mucin 16, cell surface associated | -0.082867 |
| RNF213 | ring finger protein 213 | -0.0820704 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0819932 |
| PLSCR1 | phospholipid scramblase 1 | -0.0808647 |
| ANXA2 | annexin A2 | -0.0806897 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0723341 |
| FN1 | fibronectin 1 | -0.0713921 |
| EGFR | epidermal growth factor receptor | -0.0708608 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0699992 |
| C3 | complement component 3 | -0.0668723 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0663093 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0656451 |
| SVIL | supervillin | -0.0629729 |
| VCL | vinculin | -0.0604575 |
| ACTG1 | actin gamma 1 | -0.0600351 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0587123 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0573116 |
| MYO1E | myosin IE | -0.0567732 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0555303 |
| HDAC9 | histone deacetylase 9 | -0.0540927 |
| MT2A | metallothionein 2A | -0.052549 |
| TMSB10 | thymosin beta 10 | -0.0506429 |
| EGR1 | early growth response 1 | -0.0500893 |
| SYT14 | synaptotagmin XIV | -0.0493847 |
| CD44 | CD44 molecule (Indian blood group) | -0.0489215 |
| RPL35A | ribosomal protein L35a | -0.0488724 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0483448 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0480652 |
| RPS6 | ribosomal protein S6 | -0.0473713 |
| TJP1 | tight junction protein 1 | -0.0469821 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0456958 |
| MX1 | MX dynamin-like GTPase 1 | -0.0453847 |
| ETV6 | ets variant 6 | -0.044979 |
| RIGI | RNA sensor RIG-I | -0.0447084 |
| OSMR | oncostatin M receptor | -0.0434006 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0432935 |
| TPM4 | tropomyosin 4 | -0.043238 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0427632 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0414828 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0411037 |
| RPS19 | ribosomal protein S19 | -0.0409873 |
| POTEF | POTE ankyrin domain family, member F | -0.040586 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0390834 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0383766 |
| ERBIN | erbb2 interacting protein | -0.0382909 |
| TGM2 | transglutaminase 2 | -0.038171 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0380753 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0380262 |
| RPS8 | ribosomal protein S8 | -0.0374593 |
| MX2 | MX dynamin-like GTPase 2 | -0.0374318 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0372759 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0372308 |
| RUNX1 | runt-related transcription factor 1 | -0.0371717 |
| NDRG1 | N-myc downstream regulated 1 | -0.0371466 |
| SP100 | SP100 nuclear antigen | -0.0369869 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0366409 |
| RCOR1 | REST corepressor 1 | -0.0362367 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0361917 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.036059 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0357677 |
| HMGA2 | high mobility group AT-hook 2 | -0.0357433 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0355192 |
| RAD51B | RAD51 paralog B | -0.0354523 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0353812 |
| ASPH | aspartate beta-hydroxylase | -0.0350648 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0348913 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0348076 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0346604 |
| EFNA5 | ephrin-A5 | -0.0345981 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0343168 |
| ACTN4 | actinin, alpha 4 | -0.0342925 |
| LAMC2 | laminin, gamma 2 | -0.0341368 |
| EFNB2 | ephrin-B2 | -0.0339102 |
| RPS3 | ribosomal protein S3 | -0.0338849 |
| GOLGB1 | golgin B1 | -0.0333247 |
| SEPTIN9 | septin 9 | -0.0332593 |
| MELTF | melanotransferrin | -0.0331583 |
| IFI44L | interferon-induced protein 44-like | -0.0331143 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.032845 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0320924 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -0.0311363 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0309702 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0308514 |
| JUP | junction plakoglobin | -0.0306815 |
| EHBP1 | EH domain binding protein 1 | -0.0306152 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0303333 |
| RACK1 | receptor for activated C kinase 1 | -0.030298 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.03015 |
| EMP1 | epithelial membrane protein 1 | -0.0293787 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.029153 |
| RPL37A | ribosomal protein L37a | -0.0290243 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0290015 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0286532 |
| NABP1 | nucleic acid binding protein 1 | -0.0284554 |
| PKM | pyruvate kinase, muscle | -0.0282921 |
