Bosentan (hydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0537123
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0368663
ATP13A3 ATPase type 13A3 0.0340339
ZFAND3 zinc finger, AN1-type domain 3 0.0335172
PTK2 protein tyrosine kinase 2 0.0328631
KDM6A lysine (K)-specific demethylase 6A 0.0326174
ZNF292 zinc finger protein 292 0.0305439
NUP58 nucleoporin 58 0.030224
USP3 ubiquitin specific peptidase 3 0.0299617
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0298059
FOXJ3 forkhead box J3 0.0288453
KMT2C lysine (K)-specific methyltransferase 2C 0.0268875
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0262405
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0247258
RLF rearranged L-myc fusion 0.024666
ADAM17 ADAM metallopeptidase domain 17 0.0245281
WDR43 WD repeat domain 43 0.0243864
NCKAP1 NCK-associated protein 1 0.0241866
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0233947
SBF2 SET binding factor 2 0.0233056
ZEB1 zinc finger E-box binding homeobox 1 0.0231931
UBA6 ubiquitin-like modifier activating enzyme 6 0.0230073
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0226635
USP9X ubiquitin specific peptidase 9, X-linked 0.0221361
TRA2A transformer 2 alpha homolog (Drosophila) 0.0212605
CDC73 cell division cycle 73 0.0211226
LRRC8C leucine rich repeat containing 8 family, member C 0.0210647
NEK7 NIMA-related kinase 7 0.0209996
CDK17 cyclin-dependent kinase 17 0.0199501
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0197768
CAMTA1 calmodulin binding transcription activator 1 0.0196469
PICALM phosphatidylinositol binding clathrin assembly protein 0.0195189
RBM39 RNA binding motif protein 39 0.0193113
NAMPT nicotinamide phosphoribosyltransferase 0.0192116
ADAM9 ADAM metallopeptidase domain 9 0.0189286
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0189259
ABI1 abl-interactor 1 0.0184936
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0182363
WAC WW domain containing adaptor with coiled-coil 0.018083
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0179621
BIRC6 baculoviral IAP repeat containing 6 0.0177692
RBM33 RNA binding motif protein 33 0.0177445
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0175382
FAR1 fatty acyl CoA reductase 1 0.0175177
HELZ helicase with zinc finger 0.0170143
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0169579
MED13L mediator complex subunit 13-like 0.0169512
PUM2 pumilio RNA-binding family member 2 0.0167086
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0167043
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0165679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0165359
CHD1 chromodomain helicase DNA binding protein 1 0.0165062
RAB18 RAB18, member RAS oncogene family 0.0164705
PIAS2 protein inhibitor of activated STAT, 2 0.0160871
TFG TRK-fused gene 0.0160277
BBX bobby sox homolog (Drosophila) 0.0160224
PTBP2 polypyrimidine tract binding protein 2 0.0158766
YTHDC1 YTH domain containing 1 0.0158737
RNF145 ring finger protein 145 0.0157911
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0157875
COG5 component of oligomeric golgi complex 5 0.0156109
HBS1L HBS1-like translational GTPase 0.0154775
ECT2 epithelial cell transforming 2 0.0154769
SPAG9 sperm associated antigen 9 0.0154441
EWSR1 EWS RNA-binding protein 1 0.0154434
OGA O-GlcNAcase 0.0152525
CCNL1 cyclin L1 0.0150742
ZMYM2 zinc finger, MYM-type 2 0.0150552
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0149447
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0149364
PNISR PNN-interacting serine/arginine-rich protein 0.0149235
USP24 ubiquitin specific peptidase 24 0.0147372
KDM3A lysine (K)-specific demethylase 3A 0.0146977
ANXA5 annexin A5 0.014638
RAD23B RAD23 homolog B (S. cerevisiae) 0.0146193
FMNL2 formin-like 2 0.0145964
CAPRIN2 caprin family member 2 0.0145596
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0143679
RNMT RNA (guanine-7-) methyltransferase 0.0143615
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0142633
BCLAF1 BCL2-associated transcription factor 1 0.0142261
TSC22D2 TSC22 domain family, member 2 0.0140413
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.013972
ARL5B ADP-ribosylation factor-like 5B 0.0137501
WDR26 WD repeat domain 26 0.0136998
FXR1 fragile X mental retardation, autosomal homolog 1 0.0135844
KDM2A lysine (K)-specific demethylase 2A 0.0134353
PDS5B PDS5 cohesin associated factor B 0.0134308
RASA2 RAS p21 protein activator 2 0.0134195
MEMO1 mediator of cell motility 1 0.0133868
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0132785
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0132459
KMT2E lysine (K)-specific methyltransferase 2E 0.0132439
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0131925
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0128653
MARCHF6 membrane associated ring-CH-type finger 6 0.0128477
MTF2 metal response element binding transcription factor 2 0.0127714
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0127506
TPD52 tumor protein D52 0.0127154
OLA1 Obg-like ATPase 1 0.0126689

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.186558
RPS6 ribosomal protein S6 -0.128504
ZNF438 zinc finger protein 438 -0.0914582
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0903106
TPT1 tumor protein, translationally-controlled 1 -0.0896752
RPS8 ribosomal protein S8 -0.0894956
HDAC9 histone deacetylase 9 -0.0890658
RPL35A ribosomal protein L35a -0.0880121
FRMD4A FERM domain containing 4A -0.0843674
ACTG1 actin gamma 1 -0.0835865
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0830135
DLC1 DLC1 Rho GTPase activating protein -0.0815141
RPL7A ribosomal protein L7a -0.0733958
FTL ferritin, light polypeptide -0.0731084
RPL12 ribosomal protein L12 -0.0724123
FLNB filamin B, beta -0.0703947
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0663403
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0654359
IFI16 interferon, gamma-inducible protein 16 -0.0648862
FRMD6 FERM domain containing 6 -0.0642339
RPLP1 ribosomal protein, large, P1 -0.0639755
RPS3 ribosomal protein S3 -0.0638424
TMSB10 thymosin beta 10 -0.0633477
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0604311
RPS12 ribosomal protein S12 -0.0597001
ARHGAP22 Rho GTPase activating protein 22 -0.0593917
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0593587
RPS19 ribosomal protein S19 -0.0585495
RPLP2 ribosomal protein, large, P2 -0.0571436
RPL37A ribosomal protein L37a -0.0565215
RPL8 ribosomal protein L8 -0.0558722
RPL23 ribosomal protein L23 -0.0555942
NAV3 neuron navigator 3 -0.0554042
RPL9 ribosomal protein L9 -0.0548065
NABP1 nucleic acid binding protein 1 -0.0532885
TPM4 tropomyosin 4 -0.0527345
PTMA prothymosin, alpha -0.0518718
RPL26 ribosomal protein L26 -0.0505952
RPL30 ribosomal protein L30 -0.0502479
RPL11 ribosomal protein L11 -0.0492897
LAMB3 laminin, beta 3 -0.0488449
MTDH metadherin -0.0471614
HMGA1 high mobility group AT-hook 1 -0.0463473
RPL34 ribosomal protein L34 -0.0452962
RPS29 ribosomal protein S29 -0.0448953
RPL7 ribosomal protein L7 -0.0445317
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.043909
RPS27A ribosomal protein S27a -0.0431889
RPL35 ribosomal protein L35 -0.0400078
RPL31 ribosomal protein L31 -0.0395849
RPS13 ribosomal protein S13 -0.0389779
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0386702
RPL36 ribosomal protein L36 -0.0384213
PCNX4 pecanex 4 -0.0382981
RPLP0 ribosomal protein, large, P0 -0.0375929
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0373038
EEF2 eukaryotic translation elongation factor 2 -0.0367474
HMGA2 high mobility group AT-hook 2 -0.0360658
RPS2 ribosomal protein S2 -0.0359428
RRBP1 ribosome binding protein 1 -0.0345066
NAP1L1 nucleosome assembly protein 1-like 1 -0.0341817
RPL13A ribosomal protein L13a -0.0341137
RPS24 ribosomal protein S24 -0.0335541
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0331878
SP100 SP100 nuclear antigen -0.0331659
UQCRB ubiquinol-cytochrome c reductase binding protein -0.032923
RPL19 ribosomal protein L19 -0.0327031
RPS17 ribosomal protein S17 -0.0320732
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0320165
KPNB1 karyopherin (importin) beta 1 -0.0317404
RPS25 ribosomal protein S25 -0.0317269
RPL38 ribosomal protein L38 -0.0313239
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0309887
RPS21 ribosomal protein S21 -0.0302179
S100A9 S100 calcium binding protein A9 -0.0301344
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0300484
EFNB2 ephrin-B2 -0.029907
RACK1 receptor for activated C kinase 1 -0.0296217
GNAS GNAS complex locus -0.0295288
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0294353
RPS20 ribosomal protein S20 -0.0291821
RPS10 ribosomal protein S10 -0.0288209
RPL5 ribosomal protein L5 -0.0282714
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0280425
RPL28 ribosomal protein L28 -0.027592
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0270509
BNC2 basonuclin 2 -0.0267711
EIF1 eukaryotic translation initiation factor 1 -0.026697
TM4SF1 transmembrane 4 L six family member 1 -0.0266694
RPS16 ribosomal protein S16 -0.0262241
ASPH aspartate beta-hydroxylase -0.0261224
RPS27 ribosomal protein S27 -0.0260417
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0260095
RAB7A RAB7A, member RAS oncogene family -0.0259879
MT1X metallothionein 1X -0.0254804
ALCAM activated leukocyte cell adhesion molecule -0.02547
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0252528
B2M beta-2-microglobulin -0.0251056
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0249959
PFN1 profilin 1 -0.0249398