Bosentan (hydrate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0558079
CENPF centromere protein F, 350/400kDa 0.0542308
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526372
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0500067
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.036144
ATP13A3 ATPase type 13A3 0.0331714
UBA6 ubiquitin-like modifier activating enzyme 6 0.032964
CD109 CD109 molecule 0.0321675
ECT2 epithelial cell transforming 2 0.0312577
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0309613
TFG TRK-fused gene 0.030843
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0296578
NUP58 nucleoporin 58 0.0290506
ELL2 elongation factor, RNA polymerase II, 2 0.0280064
NAMPT nicotinamide phosphoribosyltransferase 0.027546
INSIG2 insulin induced gene 2 0.0271337
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0267866
ANLN anillin, actin binding protein 0.0259711
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0258245
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0257589
PTBP2 polypyrimidine tract binding protein 2 0.0256127
ESYT2 extended synaptotagmin-like protein 2 0.0254026
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0246785
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0246098
SMC4 structural maintenance of chromosomes 4 0.0244932
XPO1 exportin 1 0.0241414
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0241227
OGA O-GlcNAcase 0.0239573
CCNL1 cyclin L1 0.0238192
KIF5B kinesin family member 5B 0.023691
MSN moesin 0.0235639
FAM13A family with sequence similarity 13, member A 0.0231802
DIAPH3 diaphanous-related formin 3 0.0231705
HELZ helicase with zinc finger 0.0229478
YEATS2 YEATS domain containing 2 0.0224787
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.022231
ADAM17 ADAM metallopeptidase domain 17 0.0216315
BCLAF1 BCL2-associated transcription factor 1 0.0214432
SUCO SUN domain containing ossification factor 0.0213289
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0208582
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0207507
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0206562
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0206079
CKAP5 cytoskeleton associated protein 5 0.0204953
CDC73 cell division cycle 73 0.0204595
NAV2 neuron navigator 2 0.020439
KDM3A lysine (K)-specific demethylase 3A 0.0202205
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0202003
NGLY1 N-glycanase 1 0.020148
KIF4A kinesin family member 4A 0.0196676
RB1CC1 RB1-inducible coiled-coil 1 0.0195174
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0192821
GOLGA4 golgin A4 0.0190629
PNISR PNN-interacting serine/arginine-rich protein 0.0189602
TRA2A transformer 2 alpha homolog (Drosophila) 0.0188209
TPX2 TPX2, microtubule-associated 0.018793
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0187748
CENPE centromere protein E, 312kDa 0.018436
SGO2 shugoshin 2 0.0180892
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0179086
KIF23 kinesin family member 23 0.0179041
HMGB2 high mobility group box 2 0.0178648
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.017811
ARHGAP12 Rho GTPase activating protein 12 0.0177391
CYLD cylindromatosis (turban tumor syndrome) 0.0175542
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0175207
GAS2L3 growth arrest-specific 2 like 3 0.0175026
TMF1 TATA element modulatory factor 1 0.0174056
PICALM phosphatidylinositol binding clathrin assembly protein 0.0172295
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0170875
ELP2 elongator acetyltransferase complex subunit 2 0.0169477
RTN4 reticulon 4 0.016877
RLF rearranged L-myc fusion 0.0167518
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0167288
RAD23B RAD23 homolog B (S. cerevisiae) 0.0166285
ZNF148 zinc finger protein 148 0.0166199
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0165449
ACBD3 acyl-CoA binding domain containing 3 0.0163979
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0163786
PPME1 protein phosphatase methylesterase 1 0.0163425
RNF145 ring finger protein 145 0.016233
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.016128
MKI67 marker of proliferation Ki-67 0.0160162
NEK7 NIMA-related kinase 7 0.0159682
NRIP1 nuclear receptor interacting protein 1 0.0158334
SPRED1 sprouty-related, EVH1 domain containing 1 0.0157891
CKAP2 cytoskeleton associated protein 2 0.0157033
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0156628
KMT2E lysine (K)-specific methyltransferase 2E 0.0156487
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0154778
MEF2A myocyte enhancer factor 2A 0.0153479
RNMT RNA (guanine-7-) methyltransferase 0.0153315
TENT2 terminal nucleotidyltransferase 2 0.015306
TP53BP1 tumor protein p53 binding protein 1 0.0151188
ARHGAP11A Rho GTPase activating protein 11A 0.0150591
LCORL ligand dependent nuclear receptor corepressor-like 0.0150429
SKIC3 SKI3 subunit of superkiller complex 0.01502
TGFBR1 transforming growth factor, beta receptor 1 0.0150105
NBAS neuroblastoma amplified sequence 0.0149728
NUF2 NUF2, NDC80 kinetochore complex component 0.0149452

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.300026
FN1 fibronectin 1 -0.287575
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147559
MT2A metallothionein 2A -0.105179
FTL ferritin, light polypeptide -0.10353
TMSB10 thymosin beta 10 -0.103287
HLA-B major histocompatibility complex, class I, B -0.100849
COL1A1 collagen, type I, alpha 1 -0.100712
B2M beta-2-microglobulin -0.0999197
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0975388
COL1A2 collagen, type I, alpha 2 -0.0965944
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0960748
FRMD4A FERM domain containing 4A -0.0862193
COL5A1 collagen, type V, alpha 1 -0.0798939
COL6A2 collagen, type VI, alpha 2 -0.0772337
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0762843
NDRG1 N-myc downstream regulated 1 -0.0754488
PSD3 pleckstrin and Sec7 domain containing 3 -0.07457
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0737072
TGFBI transforming growth factor, beta-induced, 68kDa -0.0715815
CDH13 cadherin 13 -0.0673048
EXT1 exostosin glycosyltransferase 1 -0.0668654
COL6A1 collagen, type VI, alpha 1 -0.0645357
SP100 SP100 nuclear antigen -0.0619081
LOXL2 lysyl oxidase-like 2 -0.0555821
ANXA2 annexin A2 -0.0553036
PKM pyruvate kinase, muscle -0.0537092
NAV1 neuron navigator 1 -0.05346
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0531488
EGR1 early growth response 1 -0.0529689
FAM20C family with sequence similarity 20, member C -0.052014
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0515708
RAB7A RAB7A, member RAS oncogene family -0.0500717
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0500333
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0466837
CALR calreticulin -0.0441
RPLP1 ribosomal protein, large, P1 -0.0433816
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0431469
AHNAK AHNAK nucleoprotein -0.0422836
PTMA prothymosin, alpha -0.0419547
ZBTB38 zinc finger and BTB domain containing 38 -0.0417225
IGFBP3 insulin-like growth factor binding protein 3 -0.0412201
HLA-A major histocompatibility complex, class I, A -0.0400456
IER3 immediate early response 3 -0.0394746
TPM4 tropomyosin 4 -0.0390013
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.038797
RPL35A ribosomal protein L35a -0.0383943
PTPRG protein tyrosine phosphatase, receptor type, G -0.0383762
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0379869
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0374905
TFPI2 tissue factor pathway inhibitor 2 -0.037033
TPM1 tropomyosin 1 (alpha) -0.0368615
RPS19 ribosomal protein S19 -0.0364106
ACTG1 actin gamma 1 -0.0363178
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0363163
TPT1 tumor protein, translationally-controlled 1 -0.0360361
TMEM178B transmembrane protein 178B -0.0360331
HLA-C major histocompatibility complex, class I, C -0.0357973
INHBA inhibin, beta A -0.0357659
NRP1 neuropilin 1 -0.0356617
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0355604
LMNA lamin A/C -0.035414
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0348304
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0345911
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.034468
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0339225
IFI6 interferon, alpha-inducible protein 6 -0.033758
MARCKS myristoylated alanine-rich protein kinase C substrate -0.033436
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0333547
CTSB cathepsin B -0.0330799
TGFB1 transforming growth factor, beta 1 -0.0327039
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.032701
TNS3 tensin 3 -0.0322164
VCL vinculin -0.032081
H1-0 H1.0 linker histone -0.0320143
HM13 histocompatibility (minor) 13 -0.0317903
COL5A3 collagen, type V, alpha 3 -0.031728
RPS8 ribosomal protein S8 -0.031594
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0315425
TNNC1 troponin C type 1 (slow) -0.0307844
RND3 Rho family GTPase 3 -0.0307274
GNAS GNAS complex locus -0.0305431
HDLBP high density lipoprotein binding protein -0.0304564
INTS6 integrator complex subunit 6 -0.0304436
FBN1 fibrillin 1 -0.0302215
EGFR epidermal growth factor receptor -0.0299506
RRBP1 ribosome binding protein 1 -0.0298942
POTEF POTE ankyrin domain family, member F -0.0298329
GLIS3 GLIS family zinc finger 3 -0.0297794
SLIT2 slit homolog 2 (Drosophila) -0.0294012
RPL37A ribosomal protein L37a -0.0291592
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0290446
LOC102724023 ES1 protein homolog, mitochondrial -0.0290108
NPAS2 neuronal PAS domain protein 2 -0.0290067
IFITM3 interferon induced transmembrane protein 3 -0.0284399
SERF2 small EDRK-rich factor 2 -0.0282767
ICAM1 intercellular adhesion molecule 1 -0.0278589
S100A9 S100 calcium binding protein A9 -0.0278531
MMP2 matrix metallopeptidase 2 -0.0275239
SVIL supervillin -0.0273779