| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.100578 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0898788 |
| NDRG1 | N-myc downstream regulated 1 | 0.0827133 |
| PGK1 | phosphoglycerate kinase 1 | 0.0756563 |
| DTNA | dystrobrevin, alpha | 0.0731547 |
| WDR45B | WD repeat domain 45B | 0.068055 |
| NUP58 | nucleoporin 58 | 0.066353 |
| GRB10 | growth factor receptor-bound protein 10 | 0.061729 |
| ZNF292 | zinc finger protein 292 | 0.0556449 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0553573 |
| FAM13A | family with sequence similarity 13, member A | 0.0547169 |
| RLF | rearranged L-myc fusion | 0.0534296 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0522563 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0519853 |
| ENO1 | enolase 1, (alpha) | 0.0501803 |
| CA8 | carbonic anhydrase VIII | 0.0486314 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0482116 |
| JAM3 | junctional adhesion molecule 3 | 0.0475602 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0473413 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0472342 |
| FMNL2 | formin-like 2 | 0.0463844 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0454004 |
| MATR3 | matrin 3 | 0.0440138 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.04339 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0424748 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0419838 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0405493 |
| MED13L | mediator complex subunit 13-like | 0.0400226 |
| PTK2 | protein tyrosine kinase 2 | 0.0397025 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0395094 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0390624 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0384144 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0382381 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0380727 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0376393 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0374987 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0369059 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0365916 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0353438 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0353062 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0347562 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0338976 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0336008 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0333603 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.032772 |
| NBAS | neuroblastoma amplified sequence | 0.0323811 |
| PARD3 | par-3 family cell polarity regulator | 0.0323385 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0321862 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.031929 |
| NRG1 | neuregulin 1 | 0.0316083 |
| RTN4 | reticulon 4 | 0.0310594 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0305418 |
| AHR | aryl hydrocarbon receptor | 0.0302667 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0301606 |
| PAPOLA | poly(A) polymerase alpha | 0.0299923 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0297163 |
| TFRC | transferrin receptor | 0.0294473 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0293947 |
| TPD52 | tumor protein D52 | 0.0293008 |
| GPC6 | glypican 6 | 0.0292423 |
| CCNY | cyclin Y | 0.0292109 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0287877 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0287745 |
| FAM162A | family with sequence similarity 162, member A | 0.0287529 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0285684 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0284371 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0284143 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0282385 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0274141 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0272638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0267601 |
| POU2F1 | POU class 2 homeobox 1 | 0.0267595 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.026717 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0266209 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.026499 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0264401 |
| STC1 | stanniocalcin 1 | 0.0259314 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0257802 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0253916 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0253341 |
| BMERB1 | bMERB domain containing 1 | 0.0251224 |
| RORA | RAR-related orphan receptor A | 0.0249626 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.0249453 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0246412 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0244945 |
| YY1AP1 | YY1 associated protein 1 | 0.0244623 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0243521 |
| BBX | bobby sox homolog (Drosophila) | 0.0243427 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0242892 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.024238 |
| CLINT1 | clathrin interactor 1 | 0.0242107 |
| NCKAP1 | NCK-associated protein 1 | 0.0240563 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.023887 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0236025 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0235067 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0234311 |
| USP37 | ubiquitin specific peptidase 37 | 0.02343 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0234122 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0233343 |
| XPO1 | exportin 1 | 0.0232494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.253523 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0846446 |
| VGF | VGF nerve growth factor inducible | -0.0827034 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0787468 |
| FGF14 | fibroblast growth factor 14 | -0.0779799 |
| MT2A | metallothionein 2A | -0.0745943 |
| TENM1 | teneurin transmembrane protein 1 | -0.0707961 |
| EGR1 | early growth response 1 | -0.0701584 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0646491 |
| FTL | ferritin, light polypeptide | -0.0640333 |
| CPE | carboxypeptidase E | -0.0607289 |
| SNTG1 | syntrophin, gamma 1 | -0.059217 |
| RIT2 | Ras-like without CAAX 2 | -0.0561342 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0538447 |
| SYT1 | synaptotagmin I | -0.0537127 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0529721 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0528009 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0522391 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0507484 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0506693 |
| CALCA | calcitonin-related polypeptide alpha | -0.0477945 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.0471396 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0452306 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.045015 |
| RPS3 | ribosomal protein S3 | -0.0441185 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0434747 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0425208 |
| RNF213 | ring finger protein 213 | -0.0419904 |
| NCKAP5 | NCK-associated protein 5 | -0.0410194 |
| CCDC88A | coiled-coil domain containing 88A | -0.0401298 |
| PCDH9 | protocadherin 9 | -0.0397647 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0391232 |
| INHBA | inhibin, beta A | -0.0386489 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0383261 |
| PFN1 | profilin 1 | -0.0382199 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0376387 |
| KIAA0825 | KIAA0825 | -0.0355652 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0350177 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | -0.0345903 |
| CNKSR3 | CNKSR family member 3 | -0.034433 |
| PEG10 | paternally expressed 10 | -0.0331021 |
| WWOX | WW domain containing oxidoreductase | -0.0330439 |
| GPC5 | glypican 5 | -0.0327047 |
| KIF26B | kinesin family member 26B | -0.0312036 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0311374 |
| IRS2 | insulin receptor substrate 2 | -0.0303983 |
| TMSB10 | thymosin beta 10 | -0.0303851 |
| RPS19 | ribosomal protein S19 | -0.0301714 |
| POTEF | POTE ankyrin domain family, member F | -0.0298636 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0298544 |
| GSE1 | Gse1 coiled-coil protein | -0.0297904 |
| SLC35F4 | solute carrier family 35, member F4 | -0.0293051 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.029147 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0289568 |
| ACTG1 | actin gamma 1 | -0.0289485 |
| MT1X | metallothionein 1X | -0.0285442 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0283571 |
| S100A9 | S100 calcium binding protein A9 | -0.028275 |
| FOXP1 | forkhead box P1 | -0.0279267 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0278303 |
| KLHL29 | kelch-like family member 29 | -0.027693 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0276844 |
| SIK2 | salt-inducible kinase 2 | -0.0275773 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0275633 |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | -0.02741 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0270813 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0270664 |
| RPS21 | ribosomal protein S21 | -0.026899 |
| PHF14 | PHD finger protein 14 | -0.0267336 |
| ADAR | adenosine deaminase, RNA-specific | -0.0266903 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0265175 |
| RPS8 | ribosomal protein S8 | -0.0264075 |
| MCL1 | myeloid cell leukemia 1 | -0.0262571 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0262075 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0261268 |
| EXOC4 | exocyst complex component 4 | -0.0259199 |
| RALYL | RALY RNA binding protein-like | -0.0252755 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0249346 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0245211 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.024339 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0242882 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0240296 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0235526 |
| GLIS3 | GLIS family zinc finger 3 | -0.0235223 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0232595 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0231807 |
| SLC36A4 | solute carrier family 36 (proton/amino acid symporter), member 4 | -0.0231409 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0231235 |
| RPS14 | ribosomal protein S14 | -0.0230449 |
| LSAMP | limbic system-associated membrane protein | -0.0229954 |
| RPS12 | ribosomal protein S12 | -0.0229266 |
| CDK13 | cyclin-dependent kinase 13 | -0.0229123 |
| RPL26 | ribosomal protein L26 | -0.022861 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0227769 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0223855 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0222309 |
| AUTS2 | autism susceptibility candidate 2 | -0.0222202 |
| RPL19 | ribosomal protein L19 | -0.0217173 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.021364 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0213553 |
