Bosentan (hydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bosentan (hydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104267
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0875126
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0539893
CANX calnexin 0.0493382
CXCL8 chemokine (C-X-C motif) ligand 8 0.0459697
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330647
INPP5F inositol polyphosphate-5-phosphatase F 0.0313091
EGLN1 egl-9 family hypoxia-inducible factor 1 0.027291
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0262311
IL1RAP interleukin 1 receptor accessory protein 0.0262095
NAMPT nicotinamide phosphoribosyltransferase 0.0227276
MSI2 musashi RNA-binding protein 2 0.0226599
CCDC47 coiled-coil domain containing 47 0.0219154
AKAP12 A kinase (PRKA) anchor protein 12 0.0214601
CFAP20DC CFAP20 domain containing 0.0188308
BHLHE40 basic helix-loop-helix family, member e40 0.0184581
USP3 ubiquitin specific peptidase 3 0.0183194
KDM3A lysine (K)-specific demethylase 3A 0.0182235
PRELID2 PRELI domain containing 2 0.0181042
TFRC transferrin receptor 0.0178975
HPCAL1 hippocalcin-like 1 0.0178767
MIMS1 mitochondrial inner membrane scaffold 1 0.0177776
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0173284
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0170438
CSDE1 cold shock domain containing E1, RNA-binding 0.0169953
ERRFI1 ERBB receptor feedback inhibitor 1 0.0168934
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0158578
KIF5B kinesin family member 5B 0.0156295
DENND1A DENN/MADD domain containing 1A 0.0155492
KAZN kazrin, periplakin interacting protein 0.015034
MAML3 mastermind-like 3 (Drosophila) 0.0150281
HILPDA hypoxia inducible lipid droplet-associated 0.0149926
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0146148
RAD21 RAD21 homolog (S. pombe) 0.0142585
CD109 CD109 molecule 0.0141726
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0139545
OGA O-GlcNAcase 0.0139226
ARHGAP21 Rho GTPase activating protein 21 0.0138528
BZW1 basic leucine zipper and W2 domains 1 0.0138154
FAM13A family with sequence similarity 13, member A 0.013672
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0134577
SERINC1 serine incorporator 1 0.0131852
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0131743
FAM162A family with sequence similarity 162, member A 0.0131454
PHF3 PHD finger protein 3 0.0131276
SNX14 sorting nexin 14 0.0128987
MMP12 matrix metallopeptidase 12 0.012863
ESYT2 extended synaptotagmin-like protein 2 0.012715
PDIA3 protein disulfide isomerase family A, member 3 0.0124653
USP9X ubiquitin specific peptidase 9, X-linked 0.0124427
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0121622
RLF rearranged L-myc fusion 0.0121024
MLF1 myeloid leukemia factor 1 0.0120449
MXI1 MAX interactor 1, dimerization protein 0.0120294
RNMT RNA (guanine-7-) methyltransferase 0.0119157
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0117843
NUP58 nucleoporin 58 0.0116295
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0115319
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0114884
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0114808
LARS1 leucyl-tRNA synthetase 1 0.0114102
EHBP1 EH domain binding protein 1 0.0113866
CTBP2 C-terminal binding protein 2 0.0111808
COPB1 coatomer protein complex, subunit beta 1 0.0111243
HELZ helicase with zinc finger 0.0110882
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0110701
HBP1 HMG-box transcription factor 1 0.0110336
CHD1 chromodomain helicase DNA binding protein 1 0.0110015
WDFY1 WD repeat and FYVE domain containing 1 0.0109839
LCORL ligand dependent nuclear receptor corepressor-like 0.0109706
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0108812
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.010823
UBE2O ubiquitin-conjugating enzyme E2O 0.0108192
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.010764
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0107276
TKT transketolase 0.0107154
NSD3 nuclear receptor binding SET domain protein 3 0.0106312
ZNF292 zinc finger protein 292 0.0106231
UBA2 ubiquitin-like modifier activating enzyme 2 0.0105528
USP37 ubiquitin specific peptidase 37 0.0103854
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0103795
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0103629
RYK receptor-like tyrosine kinase 0.0103489
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0103315
ARF1 ADP-ribosylation factor 1 0.0102189
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0101629
SOD2 superoxide dismutase 2, mitochondrial 0.010141
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0100149
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0100035
CALCOCO2 calcium binding and coiled-coil domain 2 0.00990389
IGFBP3 insulin-like growth factor binding protein 3 0.00985566
APP amyloid beta (A4) precursor protein 0.00973604
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00967561
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00962447
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.00950845
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00946754
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.00944987
RPS7 ribosomal protein S7 0.00934367
MLEC malectin 0.00933774
DDIT4 DNA-damage-inducible transcript 4 0.00930711

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.19841
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14396
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.106268
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0821693
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0762086
VIM vimentin -0.0757804
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0728523
ICAM1 intercellular adhesion molecule 1 -0.0700764
NLGN1 neuroligin 1 -0.0688893
POTEF POTE ankyrin domain family, member F -0.0556206
PKM pyruvate kinase, muscle -0.0551434
MT2A metallothionein 2A -0.0550668
TMSB10 thymosin beta 10 -0.0541139
NRG3 neuregulin 3 -0.0533158
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0519139
B2M beta-2-microglobulin -0.051347
SQSTM1 sequestosome 1 -0.0500677
TXNRD1 thioredoxin reductase 1 -0.0476241
FRMD4A FERM domain containing 4A -0.0468963
CD44 CD44 molecule (Indian blood group) -0.0442328
IFI6 interferon, alpha-inducible protein 6 -0.0439863
HLA-B major histocompatibility complex, class I, B -0.0439624
NDRG1 N-myc downstream regulated 1 -0.0430916
FLNA filamin A, alpha -0.0423005
ANKRD28 ankyrin repeat domain 28 -0.0421351
RPS3 ribosomal protein S3 -0.0420959
MSN moesin -0.0409955
CCND1 cyclin D1 -0.040139
HDAC9 histone deacetylase 9 -0.0397366
RUNX1 runt-related transcription factor 1 -0.0397344
RPS6 ribosomal protein S6 -0.0391442
ENO2 enolase 2 (gamma, neuronal) -0.0389738
FTL ferritin, light polypeptide -0.0385972
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0370121
FRMD5 FERM domain containing 5 -0.0369362
MAP4 microtubule-associated protein 4 -0.0367268
CTTN cortactin -0.0350219
RAB7A RAB7A, member RAS oncogene family -0.0327916
CYB5R3 cytochrome b5 reductase 3 -0.0317983
TPI1 triosephosphate isomerase 1 -0.0298562
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0290209
HMGA1 high mobility group AT-hook 1 -0.0286595
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0283837
RNF213 ring finger protein 213 -0.0277679
SETD5 SET domain containing 5 -0.0275611
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0275146
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0270112
ADAR adenosine deaminase, RNA-specific -0.0267695
PCBP2 poly(rC) binding protein 2 -0.0266826
EP300 E1A binding protein p300 -0.026598
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0263983
ACTG1 actin gamma 1 -0.0263973
KPNB1 karyopherin (importin) beta 1 -0.0259544
NOTCH2 notch 2 -0.0257984
CBX3 chromobox homolog 3 -0.0257428
BRD4 bromodomain containing 4 -0.0254356
SRPK2 SRSF protein kinase 2 -0.0251845
S100A9 S100 calcium binding protein A9 -0.0249834
RAD51B RAD51 paralog B -0.0247628
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0245081
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0241453
SOX10 SRY (sex determining region Y)-box 10 -0.0240567
RPS13 ribosomal protein S13 -0.0239125
BPTF bromodomain PHD finger transcription factor -0.0237871
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0237767
CLTC clathrin, heavy chain (Hc) -0.0233588
PRAME preferentially expressed antigen in melanoma -0.0233072
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0230141
RPS23 ribosomal protein S23 -0.0228979
MCL1 myeloid cell leukemia 1 -0.0228677
WNK1 WNK lysine deficient protein kinase 1 -0.0225978
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.022425
PLSCR1 phospholipid scramblase 1 -0.0223946
CELF1 CUGBP, Elav-like family member 1 -0.0220053
LIMS1 LIM and senescent cell antigen-like domains 1 -0.021908
RASAL2 RAS protein activator like 2 -0.0218233
TM4SF1 transmembrane 4 L six family member 1 -0.0217197
RPL35A ribosomal protein L35a -0.0216277
MED13 mediator complex subunit 13 -0.0215476
RPS21 ribosomal protein S21 -0.0215335
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0215216
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0215143
FOXP1 forkhead box P1 -0.0214402
ZBTB20 zinc finger and BTB domain containing 20 -0.0214119
PCNX4 pecanex 4 -0.021411
PGK1 phosphoglycerate kinase 1 -0.0213366
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0212709
ERBIN erbb2 interacting protein -0.0210779
SFTPA2 surfactant protein A2 -0.0210292
COMMD10 COMM domain containing 10 -0.0209757
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.020969
ACTN1 actinin, alpha 1 -0.0209343
ACTN4 actinin, alpha 4 -0.0205831
SP100 SP100 nuclear antigen -0.0205677
YBX3 Y box binding protein 3 -0.0205357
RANGAP1 Ran GTPase activating protein 1 -0.0205318
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0205079
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0204137
RTN4 reticulon 4 -0.0203015
MYH9 myosin, heavy chain 9, non-muscle -0.0201895