Bosentan (hydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0612667
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0572119
ECT2 epithelial cell transforming 2 0.0487116
NAMPT nicotinamide phosphoribosyltransferase 0.0404881
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0379476
PRELID2 PRELI domain containing 2 0.0369173
KDM3A lysine (K)-specific demethylase 3A 0.0359321
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0349057
ZNF292 zinc finger protein 292 0.0314923
CDC73 cell division cycle 73 0.0306575
RBM39 RNA binding motif protein 39 0.0274311
OGA O-GlcNAcase 0.027114
HSPA8 heat shock 70kDa protein 8 0.0232491
NUP58 nucleoporin 58 0.0229924
NCKAP1 NCK-associated protein 1 0.0213523
TFG TRK-fused gene 0.0208428
USP9X ubiquitin specific peptidase 9, X-linked 0.0208062
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0205049
RAD21 RAD21 homolog (S. pombe) 0.019668
QKI QKI, KH domain containing, RNA binding 0.019399
EIF4A2 eukaryotic translation initiation factor 4A2 0.0187075
AHNAK AHNAK nucleoprotein 0.0184549
YEATS2 YEATS domain containing 2 0.0179078
ANKRD36 ankyrin repeat domain 36 0.0175997
MED13L mediator complex subunit 13-like 0.0174546
ANK2 ankyrin 2, neuronal 0.0174402
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0173483
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0166191
PTBP2 polypyrimidine tract binding protein 2 0.0165884
MEMO1 mediator of cell motility 1 0.0161396
ADAM10 ADAM metallopeptidase domain 10 0.0158209
WAC WW domain containing adaptor with coiled-coil 0.0153031
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0152308
NBAS neuroblastoma amplified sequence 0.0150029
PLK2 polo-like kinase 2 0.0149752
MARCHF6 membrane associated ring-CH-type finger 6 0.0147667
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0145475
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143678
CD47 CD47 molecule 0.0141794
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.014069
UBA6 ubiquitin-like modifier activating enzyme 6 0.0139708
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0139142
PTK2 protein tyrosine kinase 2 0.0138752
STRN3 striatin, calmodulin binding protein 3 0.0138421
RYBP RING1 and YY1 binding protein 0.0138126
FAM13A family with sequence similarity 13, member A 0.0136719
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0136377
SPTBN1 spectrin, beta, non-erythrocytic 1 0.013521
KIF13A kinesin family member 13A 0.0134157
KDM6A lysine (K)-specific demethylase 6A 0.0133427
MTMR3 myotubularin related protein 3 0.0133357
TOP2B topoisomerase (DNA) II beta 180kDa 0.0132436
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0132254
OSBPL9 oxysterol binding protein-like 9 0.0132033
YTHDC1 YTH domain containing 1 0.0131906
FANCI Fanconi anemia, complementation group I 0.0130114
CAMTA1 calmodulin binding transcription activator 1 0.0129823
SPAG9 sperm associated antigen 9 0.0129552
UBQLN1 ubiquilin 1 0.0127475
SERINC1 serine incorporator 1 0.0127159
PRPF39 pre-mRNA processing factor 39 0.0125751
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0122117
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0120338
ANKRD10 ankyrin repeat domain 10 0.0120298
CCNT2 cyclin T2 0.0119323
ZFAND6 zinc finger, AN1-type domain 6 0.0114926
PPME1 protein phosphatase methylesterase 1 0.0113771
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0113494
ZMYM2 zinc finger, MYM-type 2 0.011313
EWSR1 EWS RNA-binding protein 1 0.0112945
AFDN afadin, adherens junction formation factor 0.0112516
CEP192 centrosomal protein 192kDa 0.011194
ANKRD36B ankyrin repeat domain 36B 0.011058
TRA2A transformer 2 alpha homolog (Drosophila) 0.0110384
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0108966
MXI1 MAX interactor 1, dimerization protein 0.0108108
ZBTB10 zinc finger and BTB domain containing 10 0.0107338
TEC tec protein tyrosine kinase 0.0107018
ZFR zinc finger RNA binding protein 0.0106896
NGLY1 N-glycanase 1 0.0106091
ADAM9 ADAM metallopeptidase domain 9 0.0105843
USP3 ubiquitin specific peptidase 3 0.0105197
ZDHHC21 zinc finger, DHHC-type containing 21 0.0104611
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0104195
SNX9 sorting nexin 9 0.0102936
SUN1 Sad1 and UNC84 domain containing 1 0.0102739
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0102432
COG6 component of oligomeric golgi complex 6 0.0102285
ATP9B ATPase, class II, type 9B 0.0101345
MIER3 mesoderm induction early response 1, family member 3 0.0101255
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.010066
JAK2 Janus kinase 2 0.0100465
MED6 mediator complex subunit 6 0.0100087
NEK7 NIMA-related kinase 7 0.00992881
NBPF15 neuroblastoma breakpoint family, member 15 0.00991539
ELP2 elongator acetyltransferase complex subunit 2 0.00976429
RHEB Ras homolog enriched in brain 0.00968055
RAB14 RAB14, member RAS oncogene family 0.00966258
MACROD2 MACRO domain containing 2 0.00964308
SPPL3 signal peptide peptidase like 3 0.00959935

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.224513
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140621
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.139144
PDE4B phosphodiesterase 4B, cAMP-specific -0.13211
CPED1 cadherin-like and PC-esterase domain containing 1 -0.123681
FOXP1 forkhead box P1 -0.0963452
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0872463
EGFR epidermal growth factor receptor -0.0863315
VCL vinculin -0.0804876
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0785782
RPL35A ribosomal protein L35a -0.0709985
RPS6 ribosomal protein S6 -0.070759
HDAC9 histone deacetylase 9 -0.0679917
RPS8 ribosomal protein S8 -0.0670358
PKM pyruvate kinase, muscle -0.0667591
RPS19 ribosomal protein S19 -0.0643822
S100A6 S100 calcium binding protein A6 -0.0641074
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0629962
RPS3 ribosomal protein S3 -0.0628467
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0618561
PFN1 profilin 1 -0.0618173
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0612664
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.056561
MT2A metallothionein 2A -0.0555121
RPLP2 ribosomal protein, large, P2 -0.0535742
TJP1 tight junction protein 1 -0.052397
NPAS2 neuronal PAS domain protein 2 -0.0518287
ACTG1 actin gamma 1 -0.0515839
NBEA neurobeachin -0.0496543
SOX6 SRY (sex determining region Y)-box 6 -0.0490207
RPL31 ribosomal protein L31 -0.0481662
RPL36 ribosomal protein L36 -0.0471193
ENO2 enolase 2 (gamma, neuronal) -0.0470551
RPL23 ribosomal protein L23 -0.0467201
ANKRD17 ankyrin repeat domain 17 -0.0464889
B2M beta-2-microglobulin -0.0459651
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0446241
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0437567
ZMYND8 zinc finger, MYND-type containing 8 -0.0433527
RPS13 ribosomal protein S13 -0.0427159
EIF1 eukaryotic translation initiation factor 1 -0.041915
RPL12 ribosomal protein L12 -0.0418493
FTL ferritin, light polypeptide -0.0417976
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0411842
RPLP1 ribosomal protein, large, P1 -0.0407021
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0394166
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0391155
PRDX2 peroxiredoxin 2 -0.0386668
RPL37 ribosomal protein L37 -0.0372015
RPL26 ribosomal protein L26 -0.0370598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0366688
RPL9 ribosomal protein L9 -0.0363954
NAP1L1 nucleosome assembly protein 1-like 1 -0.0363208
TXNRD1 thioredoxin reductase 1 -0.0363119
TPT1 tumor protein, translationally-controlled 1 -0.0362034
RPS12 ribosomal protein S12 -0.0361946
S100A9 S100 calcium binding protein A9 -0.035709
RPL7A ribosomal protein L7a -0.0356302
RPL34 ribosomal protein L34 -0.0353033
RPS29 ribosomal protein S29 -0.0349331
RPS25 ribosomal protein S25 -0.0341038
GPHN gephyrin -0.0340281
RPL11 ribosomal protein L11 -0.0338615
HMGA1 high mobility group AT-hook 1 -0.0335276
POTEF POTE ankyrin domain family, member F -0.0332661
DLG1 discs, large homolog 1 (Drosophila) -0.0331206
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0328565
HDLBP high density lipoprotein binding protein -0.0326548
NFIA nuclear factor I/A -0.0325596
TMSB10 thymosin beta 10 -0.032466
MBNL1 muscleblind-like splicing regulator 1 -0.0317877
ARL4C ADP-ribosylation factor-like 4C -0.0317468
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0315078
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0312979
RPL5 ribosomal protein L5 -0.0312134
GNAS GNAS complex locus -0.0309407
HSPB1 heat shock 27kDa protein 1 -0.0308538
RPS27 ribosomal protein S27 -0.0307311
RPL37A ribosomal protein L37a -0.0306853
ENO1 enolase 1, (alpha) -0.0305529
EEF2 eukaryotic translation elongation factor 2 -0.0305317
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0304602
BPTF bromodomain PHD finger transcription factor -0.0303611
RPS27A ribosomal protein S27a -0.030279
MTDH metadherin -0.030179
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0300479
BMP10 bone morphogenetic protein 10 -0.0300128
EFNA5 ephrin-A5 -0.0296176
PDE4D phosphodiesterase 4D, cAMP-specific -0.0294668
EML4 echinoderm microtubule associated protein like 4 -0.0293017
RPL13A ribosomal protein L13a -0.0292246
DPYD dihydropyrimidine dehydrogenase -0.0289736
CAMKMT calmodulin-lysine N-methyltransferase -0.0288912
MKI67 marker of proliferation Ki-67 -0.0288547
RPL27A ribosomal protein L27a -0.02852
GOLGA4 golgin A4 -0.0284617
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0284135
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0282384
RPL19 ribosomal protein L19 -0.0281921
KPNB1 karyopherin (importin) beta 1 -0.0281798