| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0851248 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0537091 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0489227 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0434257 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0380062 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0324126 |
| ARRDC3 | arrestin domain containing 3 | 0.0304258 |
| GOLGA4 | golgin A4 | 0.0300064 |
| OGA | O-GlcNAcase | 0.0297252 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.029375 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0290121 |
| ATP13A3 | ATPase type 13A3 | 0.0287104 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0283805 |
| ANLN | anillin, actin binding protein | 0.0269447 |
| MATR3 | matrin 3 | 0.0255906 |
| ZNF292 | zinc finger protein 292 | 0.024709 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0242699 |
| CENPF | centromere protein F, 350/400kDa | 0.0240537 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0239073 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0234027 |
| SPAG9 | sperm associated antigen 9 | 0.0225811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0222182 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0221833 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0218173 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0214717 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0211316 |
| SERINC1 | serine incorporator 1 | 0.0207562 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0206921 |
| DIAPH3 | diaphanous-related formin 3 | 0.0200822 |
| MKI67 | marker of proliferation Ki-67 | 0.019963 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0199548 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0190535 |
| CKAP5 | cytoskeleton associated protein 5 | 0.018542 |
| XPO1 | exportin 1 | 0.0179472 |
| TFG | TRK-fused gene | 0.0178628 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.017038 |
| NUP58 | nucleoporin 58 | 0.0163912 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0159107 |
| TPX2 | TPX2, microtubule-associated | 0.0158118 |
| RLF | rearranged L-myc fusion | 0.015732 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0154791 |
| NEK7 | NIMA-related kinase 7 | 0.0154519 |
| YBX1 | Y box binding protein 1 | 0.0154405 |
| UBQLN1 | ubiquilin 1 | 0.0150823 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0148488 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0147854 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0147297 |
| USP37 | ubiquitin specific peptidase 37 | 0.0146406 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0146382 |
| NUP153 | nucleoporin 153kDa | 0.0145305 |
| DSTN | destrin (actin depolymerizing factor) | 0.0144966 |
| USP3 | ubiquitin specific peptidase 3 | 0.014448 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0143961 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0143775 |
| HELZ | helicase with zinc finger | 0.0143745 |
| SUCO | SUN domain containing ossification factor | 0.0143029 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0141691 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.014158 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0141324 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.014098 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.013996 |
| SDC4 | syndecan 4 | 0.0139276 |
| NONO | non-POU domain containing, octamer-binding | 0.0138947 |
| SET | SET nuclear proto-oncogene | 0.0138113 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0138047 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0135312 |
| ABI1 | abl-interactor 1 | 0.0134871 |
| WDR43 | WD repeat domain 43 | 0.0134465 |
| WTAP | Wilms tumor 1 associated protein | 0.0134359 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0134058 |
| ECT2 | epithelial cell transforming 2 | 0.013391 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0133561 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0133338 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0132677 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0132511 |
| SRGN | serglycin | 0.0132477 |
| TPM3 | tropomyosin 3 | 0.0131939 |
| KIF4A | kinesin family member 4A | 0.0130729 |
| HMGB2 | high mobility group box 2 | 0.0130522 |
| IPO7 | importin 7 | 0.0130465 |
| PHIP | pleckstrin homology domain interacting protein | 0.0129066 |
| UVRAG | UV radiation resistance associated | 0.0127243 |
| CCNL1 | cyclin L1 | 0.012682 |
| ANXA5 | annexin A5 | 0.0126338 |
| RNF145 | ring finger protein 145 | 0.01251 |
| ZFR | zinc finger RNA binding protein | 0.0123364 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0123182 |
| TMF1 | TATA element modulatory factor 1 | 0.011995 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0119524 |
| DENND4C | DENN/MADD domain containing 4C | 0.0118548 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0118052 |
| TTK | TTK protein kinase | 0.0118012 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.0117641 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0116711 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | 0.011633 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0115528 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0114954 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0113548 |
| EZR | ezrin | 0.0111871 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0111361 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.190479 |
| FRMD4A | FERM domain containing 4A | -0.16042 |
| GLIS3 | GLIS family zinc finger 3 | -0.146306 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.139461 |
| COL6A3 | collagen, type VI, alpha 3 | -0.118941 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.114771 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.114226 |
| CD44 | CD44 molecule (Indian blood group) | -0.10554 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.10162 |
| HMGA2 | high mobility group AT-hook 2 | -0.0925719 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0886618 |
| HDAC9 | histone deacetylase 9 | -0.0850434 |
| NDRG1 | N-myc downstream regulated 1 | -0.0849156 |
| HLA-B | major histocompatibility complex, class I, B | -0.0826477 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0814925 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0806132 |
| VCL | vinculin | -0.0793898 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0791683 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0785067 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0778858 |
| TMSB10 | thymosin beta 10 | -0.0719806 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0700551 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.068916 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.064877 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0638771 |
| PDE10A | phosphodiesterase 10A | -0.0633888 |
| FTL | ferritin, light polypeptide | -0.0633735 |
| TNS3 | tensin 3 | -0.0632749 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0605105 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0604104 |
| VEGFA | vascular endothelial growth factor A | -0.0595362 |
| CDH13 | cadherin 13 | -0.0584859 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0568653 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0563383 |
| NAV1 | neuron navigator 1 | -0.0554927 |
| DST | dystonin | -0.0550313 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0542824 |
| BICC1 | BicC family RNA binding protein 1 | -0.0534789 |
| ATXN1 | ataxin 1 | -0.0522296 |
| RNF213 | ring finger protein 213 | -0.0512902 |
| INTS6 | integrator complex subunit 6 | -0.0511845 |
| KYNU | kynureninase | -0.0486229 |
| RAI14 | retinoic acid induced 14 | -0.0481666 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0481459 |
| NABP1 | nucleic acid binding protein 1 | -0.0481374 |
| DIAPH2 | diaphanous-related formin 2 | -0.0481236 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0475916 |
| C3 | complement component 3 | -0.0462523 |
| EGFR | epidermal growth factor receptor | -0.0456436 |
| IER3 | immediate early response 3 | -0.0453331 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0431886 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0425179 |
| VCAN | versican | -0.042242 |
| COL5A1 | collagen, type V, alpha 1 | -0.0422045 |
| RAD51B | RAD51 paralog B | -0.0421305 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0418976 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0409497 |
| HLA-A | major histocompatibility complex, class I, A | -0.0399166 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0396506 |
| ASPH | aspartate beta-hydroxylase | -0.0392838 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0388131 |
| MT2A | metallothionein 2A | -0.0387029 |
| SMAD3 | SMAD family member 3 | -0.0385397 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0383706 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0380286 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0378736 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0378293 |
| SEPTIN9 | septin 9 | -0.0374691 |
| EFNA5 | ephrin-A5 | -0.0370893 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.03686 |
| EGR1 | early growth response 1 | -0.0367425 |
| GPC6 | glypican 6 | -0.0365628 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0363423 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.036036 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0360312 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0358558 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0353381 |
| TMEM132D | transmembrane protein 132D | -0.0351667 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0349775 |
| SMYD3 | SET and MYND domain containing 3 | -0.0349023 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0348928 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0348192 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0345237 |
| RUNX1 | runt-related transcription factor 1 | -0.0344131 |
| SQSTM1 | sequestosome 1 | -0.0338794 |
| RIGI | RNA sensor RIG-I | -0.0337407 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0330897 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0329879 |
| FAM20C | family with sequence similarity 20, member C | -0.0329787 |
| RND3 | Rho family GTPase 3 | -0.0328131 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0326002 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0321846 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0319798 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0318479 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.031745 |
| CTSD | cathepsin D | -0.0313423 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0312922 |
| MYOF | myoferlin | -0.0312346 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0311869 |
| FLNB | filamin B, beta | -0.0309102 |
