| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.137836 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0914584 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0641835 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.060264 |
| GOLGA4 | golgin A4 | 0.0562435 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0562034 |
| PTK2 | protein tyrosine kinase 2 | 0.0514425 |
| ADM | adrenomedullin | 0.0499191 |
| ZNF451 | zinc finger protein 451 | 0.0482843 |
| RNF145 | ring finger protein 145 | 0.0460866 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0450623 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0442302 |
| TOP1 | topoisomerase (DNA) I | 0.0428664 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0425337 |
| OGA | O-GlcNAcase | 0.0408131 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0402496 |
| CD109 | CD109 molecule | 0.0397819 |
| RLF | rearranged L-myc fusion | 0.0387753 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0386487 |
| ARRDC3 | arrestin domain containing 3 | 0.0380697 |
| EFHD2 | EF-hand domain family, member D2 | 0.0380419 |
| ANXA5 | annexin A5 | 0.0378029 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0374196 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0363047 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0360612 |
| GDNF | glial cell derived neurotrophic factor | 0.0352172 |
| NUP58 | nucleoporin 58 | 0.0347201 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0336743 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0334579 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0330995 |
| ZNF292 | zinc finger protein 292 | 0.0327251 |
| POMP | proteasome maturation protein | 0.032524 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0322102 |
| ATP11A | ATPase, class VI, type 11A | 0.0320185 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0316953 |
| MT2A | metallothionein 2A | 0.0312417 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0309137 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0307192 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0303421 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0303273 |
| TMSB4X | thymosin beta 4, X-linked | 0.0300749 |
| RPL23 | ribosomal protein L23 | 0.0297495 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0293856 |
| RPL15 | ribosomal protein L15 | 0.0289081 |
| CDK6 | cyclin-dependent kinase 6 | 0.028681 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0285633 |
| TENM3 | teneurin transmembrane protein 3 | 0.0279563 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0275502 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0275277 |
| WDR26 | WD repeat domain 26 | 0.0274361 |
| THOC2 | THO complex 2 | 0.0274123 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0272442 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0272113 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.026898 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0267741 |
| LMO7 | LIM domain 7 | 0.0267053 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0266557 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0263176 |
| XPO1 | exportin 1 | 0.0262317 |
| EP300 | E1A binding protein p300 | 0.026202 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0261924 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0261141 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.026051 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0259218 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0255625 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0252497 |
| IKBIP | IKBKB interacting protein | 0.0252091 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0251858 |
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 0.025179 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.025066 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.02498 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0245973 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0244593 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0243915 |
| INSIG2 | insulin induced gene 2 | 0.0243712 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0243344 |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 0.0243114 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0242816 |
| DENND5A | DENN/MADD domain containing 5A | 0.0242792 |
| FMNL2 | formin-like 2 | 0.0242492 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0241709 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0241267 |
| ANXA1 | annexin A1 | 0.0240388 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0236967 |
| COPA | coatomer protein complex, subunit alpha | 0.0236863 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0235686 |
| FBXO7 | F-box protein 7 | 0.0234779 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0234716 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0234225 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0233529 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0233287 |
| GINM1 | glycoprotein integral membrane 1 | 0.0233083 |
| FLNB | filamin B, beta | 0.023266 |
| LNPK | lunapark, ER junction formation factor | 0.0232362 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0231837 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0231655 |
| CCNY | cyclin Y | 0.0230365 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.022972 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0229504 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229002 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191189 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185767 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.167466 |
| FN1 | fibronectin 1 | -0.108894 |
| HLA-B | major histocompatibility complex, class I, B | -0.107298 |
| TMSB10 | thymosin beta 10 | -0.0913537 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0862286 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0808607 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0739269 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0730628 |
| COL5A1 | collagen, type V, alpha 1 | -0.0721202 |
| LOXL2 | lysyl oxidase-like 2 | -0.0690028 |
| B2M | beta-2-microglobulin | -0.0644134 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0615655 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0614852 |
| COL6A1 | collagen, type VI, alpha 1 | -0.058657 |
| HLA-C | major histocompatibility complex, class I, C | -0.0570779 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0568346 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.055611 |
| VIM | vimentin | -0.0543491 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0543328 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0514308 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0513173 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0491414 |
| PRELID2 | PRELI domain containing 2 | -0.0479765 |
| RUNX1 | runt-related transcription factor 1 | -0.0451334 |
| AUTS2 | autism susceptibility candidate 2 | -0.0442502 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0432111 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0414966 |
| HLA-A | major histocompatibility complex, class I, A | -0.0414015 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0393256 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.039059 |
| SEPTIN2 | septin 2 | -0.0389402 |
| NAV1 | neuron navigator 1 | -0.0385949 |
| VCL | vinculin | -0.0381237 |
| MAP1B | microtubule-associated protein 1B | -0.0380303 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0379668 |
| WASF2 | WAS protein family, member 2 | -0.0376774 |
| FAM20C | family with sequence similarity 20, member C | -0.0365793 |
| RPL28 | ribosomal protein L28 | -0.0363647 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0361912 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0356748 |
| COL1A2 | collagen, type I, alpha 2 | -0.0343026 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0339973 |
| HDLBP | high density lipoprotein binding protein | -0.0338365 |
| CD44 | CD44 molecule (Indian blood group) | -0.0336883 |
| CALU | calumenin | -0.033563 |
| MAP4 | microtubule-associated protein 4 | -0.0335175 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0333158 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0332193 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0331819 |
| STC1 | stanniocalcin 1 | -0.0329121 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0328722 |
| INHBA | inhibin, beta A | -0.0324143 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0322716 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0322111 |
| S100A9 | S100 calcium binding protein A9 | -0.0320453 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0318909 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0316674 |
| S100A10 | S100 calcium binding protein A10 | -0.0310616 |
| IL6ST | interleukin 6 signal transducer | -0.0296722 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0294667 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0293563 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0292778 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0291994 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0291492 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0290943 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0290279 |
| EGR1 | early growth response 1 | -0.0289915 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0287379 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.028654 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0286171 |
| RBM39 | RNA binding motif protein 39 | -0.0280951 |
| NRXN3 | neurexin 3 | -0.0280757 |
| LOX | lysyl oxidase | -0.0280394 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0275667 |
| FUS | FUS RNA binding protein | -0.0272377 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0271717 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0271251 |
| POLK | polymerase (DNA directed) kappa | -0.0271035 |
| SUCO | SUN domain containing ossification factor | -0.0269529 |
| TVP23C-CDRT4 | TVP23C-CDRT4 readthrough | -0.0268838 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0268818 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0267841 |
| SON | SON DNA binding protein | -0.0264613 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0263479 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0261948 |
| NOP58 | NOP58 ribonucleoprotein | -0.0259631 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.025942 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.025886 |
| UBC | ubiquitin C | -0.0255093 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0254608 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.025333 |
| TMEM165 | transmembrane protein 165 | -0.0253136 |
| FLOT1 | flotillin 1 | -0.0252858 |
| EGFR | epidermal growth factor receptor | -0.0252416 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0252385 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0252202 |
| GNAS | GNAS complex locus | -0.0247657 |
| ACTN4 | actinin, alpha 4 | -0.0246092 |
