| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bosentan (hydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | 0.0875451 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0684925 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0656044 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0608994 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0580669 |
| GOLGA4 | golgin A4 | 0.0566738 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0510707 |
| CENPF | centromere protein F, 350/400kDa | 0.0499727 |
| NUP58 | nucleoporin 58 | 0.0494426 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0459253 |
| KIF5B | kinesin family member 5B | 0.0448675 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0433649 |
| RBM39 | RNA binding motif protein 39 | 0.0424909 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0421945 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0404169 |
| NAV2 | neuron navigator 2 | 0.0401626 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.039351 |
| KIAA1328 | KIAA1328 | 0.0384832 |
| IL6ST | interleukin 6 signal transducer | 0.0372329 |
| TPX2 | TPX2, microtubule-associated | 0.0369649 |
| GPR107 | G protein-coupled receptor 107 | 0.0367128 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0364715 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0354494 |
| PHIP | pleckstrin homology domain interacting protein | 0.0352017 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0352011 |
| FANCM | Fanconi anemia, complementation group M | 0.0344854 |
| TFG | TRK-fused gene | 0.0340448 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0325263 |
| RDX | radixin | 0.0325064 |
| CLTC | clathrin, heavy chain (Hc) | 0.0324637 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0318596 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0314961 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0314673 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0305876 |
| MED13L | mediator complex subunit 13-like | 0.030497 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0303846 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0299748 |
| ENO1 | enolase 1, (alpha) | 0.0298988 |
| RPL11 | ribosomal protein L11 | 0.0292669 |
| UBQLN1 | ubiquilin 1 | 0.0288282 |
| FAM76B | family with sequence similarity 76, member B | 0.0283681 |
| CEP70 | centrosomal protein 70kDa | 0.0282457 |
| ECT2 | epithelial cell transforming 2 | 0.0282361 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0280526 |
| SET | SET nuclear proto-oncogene | 0.0277979 |
| CEP97 | centrosomal protein 97kDa | 0.0276893 |
| UVRAG | UV radiation resistance associated | 0.027567 |
| NKTR | natural killer cell triggering receptor | 0.0274614 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0273941 |
| RSF1 | remodeling and spacing factor 1 | 0.0273383 |
| NBAS | neuroblastoma amplified sequence | 0.0273161 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0272447 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0269768 |
| ANLN | anillin, actin binding protein | 0.0269439 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0268954 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0268334 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0264621 |
| SKP1 | S-phase kinase-associated protein 1 | 0.026428 |
| PHF14 | PHD finger protein 14 | 0.0262189 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0262052 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0261036 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0259013 |
| RPL23 | ribosomal protein L23 | 0.0257583 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0256917 |
| KIF4A | kinesin family member 4A | 0.0256686 |
| DIAPH3 | diaphanous-related formin 3 | 0.0256533 |
| PDS5B | PDS5 cohesin associated factor B | 0.0255398 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0253139 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0252806 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.025275 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0251362 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0249209 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0248118 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0246204 |
| RPL37A | ribosomal protein L37a | 0.0244314 |
| MATR3 | matrin 3 | 0.0242349 |
| TMEM41B | transmembrane protein 41B | 0.0241413 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0240457 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0239327 |
| CEP170 | centrosomal protein 170kDa | 0.0238488 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0236845 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 0.0236221 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.023572 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0234987 |
| CALR | calreticulin | 0.0234343 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0234124 |
| KIF15 | kinesin family member 15 | 0.0232625 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0232541 |
| RNF145 | ring finger protein 145 | 0.0232309 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0231716 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0230625 |
| HMGB2 | high mobility group box 2 | 0.0229122 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0228848 |
| ZFR | zinc finger RNA binding protein | 0.0227919 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0227389 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.0227207 |
| RTN4 | reticulon 4 | 0.0225666 |
| CCNB1 | cyclin B1 | 0.0224992 |
| CASC3 | cancer susceptibility candidate 3 | 0.0224737 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0223788 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253096 |
| FNDC3B | fibronectin type III domain containing 3B | -0.142346 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.11298 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.102074 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.100209 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0896448 |
| VIM | vimentin | -0.0867747 |
| LDHA | lactate dehydrogenase A | -0.0863184 |
| TMSB10 | thymosin beta 10 | -0.0852151 |
| PKM | pyruvate kinase, muscle | -0.0814874 |
| NDRG1 | N-myc downstream regulated 1 | -0.0724835 |
| RIGI | RNA sensor RIG-I | -0.0711649 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0700509 |
| CD44 | CD44 molecule (Indian blood group) | -0.0676051 |
| PRKCA | protein kinase C, alpha | -0.0672477 |
| ANGPTL4 | angiopoietin-like 4 | -0.0608675 |
| HMGA2 | high mobility group AT-hook 2 | -0.0606273 |
| FLNB | filamin B, beta | -0.0592435 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0591043 |
| POTEF | POTE ankyrin domain family, member F | -0.0568681 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0545802 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.054536 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0541334 |
| IGF2 | insulin-like growth factor 2 | -0.0528615 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0520414 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0518486 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.05149 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0505364 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0496509 |
| EGR1 | early growth response 1 | -0.0496496 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.048855 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0479536 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0478913 |
| RAI14 | retinoic acid induced 14 | -0.0474078 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0473577 |
| FMNL2 | formin-like 2 | -0.0459988 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0458605 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0458232 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0456521 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0449333 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0444704 |
| B2M | beta-2-microglobulin | -0.0444412 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0443215 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0439626 |
| ANXA2 | annexin A2 | -0.0435607 |
| ATXN1 | ataxin 1 | -0.0430711 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0429471 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0429045 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0423733 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0422142 |
| SMAD3 | SMAD family member 3 | -0.0421555 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0415396 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0411742 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0410866 |
| SETD5 | SET domain containing 5 | -0.0410595 |
| PTK2 | protein tyrosine kinase 2 | -0.0408715 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.040734 |
| PTMA | prothymosin, alpha | -0.0398027 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0397928 |
| IER3 | immediate early response 3 | -0.039146 |
| RUNX1 | runt-related transcription factor 1 | -0.0390069 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0388306 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0386975 |
| ZNF638 | zinc finger protein 638 | -0.0384115 |
| SETX | senataxin | -0.0378049 |
| DTNA | dystrobrevin, alpha | -0.0375928 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.03699 |
| MYO9B | myosin IXB | -0.0368012 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0365151 |
| CAPRIN2 | caprin family member 2 | -0.0350431 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0348718 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0348164 |
| SLC38A2 | solute carrier family 38, member 2 | -0.034813 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0345766 |
| ADM | adrenomedullin | -0.034536 |
| INTS6 | integrator complex subunit 6 | -0.0345291 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0339585 |
| OSMR | oncostatin M receptor | -0.0336071 |
| S100A10 | S100 calcium binding protein A10 | -0.0333325 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0332036 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0331759 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0329285 |
| RNF213 | ring finger protein 213 | -0.0328321 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0327515 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0325207 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0324658 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0320635 |
| EFNA5 | ephrin-A5 | -0.0320398 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.031828 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0316556 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0315869 |
| MCL1 | myeloid cell leukemia 1 | -0.031423 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0312685 |
| PCNX4 | pecanex 4 | -0.0311229 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.0309866 |
| PRSS23 | protease, serine, 23 | -0.0308212 |
| BPTF | bromodomain PHD finger transcription factor | -0.030813 |
| EGFR | epidermal growth factor receptor | -0.0304956 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.030478 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0304728 |
