Bosentan (hydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114963
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0918158
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0647619
KDM3A lysine (K)-specific demethylase 3A 0.0628449
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0623403
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0601729
CANX calnexin 0.0584447
HSPA8 heat shock 70kDa protein 8 0.055312
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0546732
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0544175
DSPP dentin sialophosphoprotein 0.0539671
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0525654
FXR1 fragile X mental retardation, autosomal homolog 1 0.0513491
MATR3 matrin 3 0.0492416
RAD21 RAD21 homolog (S. pombe) 0.0467695
USP3 ubiquitin specific peptidase 3 0.0459285
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0451297
RBM39 RNA binding motif protein 39 0.0446871
OGA O-GlcNAcase 0.0440378
ZNF292 zinc finger protein 292 0.0381627
HMGB2 high mobility group box 2 0.0376859
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0375696
NCKAP1 NCK-associated protein 1 0.0374094
PGK1 phosphoglycerate kinase 1 0.0373347
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0343038
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0341716
SQSTM1 sequestosome 1 0.0339051
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333227
ARHGAP32 Rho GTPase activating protein 32 0.0328753
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0327587
FAR1 fatty acyl CoA reductase 1 0.0324227
SPAG9 sperm associated antigen 9 0.0322436
TPX2 TPX2, microtubule-associated 0.0322247
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0312246
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0311811
FNBP1L formin binding protein 1-like 0.0311085
NAMPT nicotinamide phosphoribosyltransferase 0.0310801
SET SET nuclear proto-oncogene 0.0303724
PTK2 protein tyrosine kinase 2 0.0303696
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0301313
ANKRD11 ankyrin repeat domain 11 0.0300421
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.029831
UBQLN1 ubiquilin 1 0.0297963
RAB1A RAB1A, member RAS oncogene family 0.0295894
EPCAM epithelial cell adhesion molecule 0.0295787
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.029516
XPO1 exportin 1 0.0293246
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0285
NAP1L1 nucleosome assembly protein 1-like 1 0.027474
PUM2 pumilio RNA-binding family member 2 0.0273136
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0272732
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0272314
KDM6A lysine (K)-specific demethylase 6A 0.0271858
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0271348
STX16 syntaxin 16 0.0271251
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266202
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0263886
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0263352
TMF1 TATA element modulatory factor 1 0.0262594
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0260583
AHNAK AHNAK nucleoprotein 0.0258422
KMT2C lysine (K)-specific methyltransferase 2C 0.0257739
CENPF centromere protein F, 350/400kDa 0.0257299
SETD2 SET domain containing 2 0.0250331
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0243887
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.024194
PDS5B PDS5 cohesin associated factor B 0.0241128
AFDN afadin, adherens junction formation factor 0.0237212
JMJD1C jumonji domain containing 1C 0.0236209
LDHA lactate dehydrogenase A 0.0235255
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0234663
AKAP12 A kinase (PRKA) anchor protein 12 0.0233673
PDIA3 protein disulfide isomerase family A, member 3 0.0233394
ADAM17 ADAM metallopeptidase domain 17 0.0232578
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0232178
NAV2 neuron navigator 2 0.0230306
SFPQ splicing factor proline/glutamine-rich 0.0229977
BBX bobby sox homolog (Drosophila) 0.022809
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0224795
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0220656
BZW1 basic leucine zipper and W2 domains 1 0.0220401
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0220393
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0220365
RBM33 RNA binding motif protein 33 0.0219682
TCEA1 transcription elongation factor A (SII), 1 0.0219156
HBP1 HMG-box transcription factor 1 0.0217936
DIDO1 death inducer-obliterator 1 0.0216501
TOP2B topoisomerase (DNA) II beta 180kDa 0.0215447
USP9X ubiquitin specific peptidase 9, X-linked 0.0213056
SERINC1 serine incorporator 1 0.0212176
FMR1 fragile X mental retardation 1 0.0212129
TM9SF3 transmembrane 9 superfamily member 3 0.0211914
CKAP5 cytoskeleton associated protein 5 0.0211559
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0211469
USP24 ubiquitin specific peptidase 24 0.0211075
HELZ helicase with zinc finger 0.0209088
RLF rearranged L-myc fusion 0.0208958
RNF149 ring finger protein 149 0.0208317
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0207216
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0206359

decreased expression

Symbol Name Standardized Value
BCL2L1 BCL2-like 1 -0.149709
FTL ferritin, light polypeptide -0.137988
TMSB10 thymosin beta 10 -0.107723
NCEH1 neutral cholesterol ester hydrolase 1 -0.0994606
MACC1 metastasis associated in colon cancer 1 -0.0896116
EGR1 early growth response 1 -0.0877861
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0720267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0702066
FTH1 ferritin, heavy polypeptide 1 -0.0673704
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0587683
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0573736
VCL vinculin -0.0566621
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0528855
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0526777
RPL35A ribosomal protein L35a -0.0507473
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0507046
MAML2 mastermind-like 2 (Drosophila) -0.049912
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.04794
CST3 cystatin C -0.0453585
GNAS GNAS complex locus -0.0433053
WWC1 WW and C2 domain containing 1 -0.0411543
HM13 histocompatibility (minor) 13 -0.0410802
RPS19 ribosomal protein S19 -0.0405357
CLDN4 claudin 4 -0.0404838
JUP junction plakoglobin -0.038957
LOC112694756 uncharaterized LOC112694756 -0.0383218
RPLP2 ribosomal protein, large, P2 -0.0377923
MYO1E myosin IE -0.0375758
RPS21 ribosomal protein S21 -0.0375584
TGFA transforming growth factor, alpha -0.0375086
HLA-A major histocompatibility complex, class I, A -0.0372187
OXSR1 oxidative stress responsive 1 -0.0366386
B2M beta-2-microglobulin -0.0364488
RPS12 ribosomal protein S12 -0.0362643
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0359984
RUNX1 runt-related transcription factor 1 -0.0356757
FHL2 four and a half LIM domains 2 -0.0353487
RAB7A RAB7A, member RAS oncogene family -0.0352492
MYOF myoferlin -0.0351088
NEBL nebulette -0.0344116
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0338408
HMGA1 high mobility group AT-hook 1 -0.0333259
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0331302
RPL28 ribosomal protein L28 -0.0328335
TOP1 topoisomerase (DNA) I -0.0326362
NRP1 neuropilin 1 -0.0318864
ZBTB38 zinc finger and BTB domain containing 38 -0.0315981
UBAP2 ubiquitin associated protein 2 -0.0315879
SHB Src homology 2 domain containing adaptor protein B -0.0315734
PLSCR1 phospholipid scramblase 1 -0.031139
LOC102724023 ES1 protein homolog, mitochondrial -0.030858
ACTN4 actinin, alpha 4 -0.030847
MX2 MX dynamin-like GTPase 2 -0.0305628
GSTP1 glutathione S-transferase pi 1 -0.0303417
FAM3C family with sequence similarity 3, member C -0.0300396
ITGB4 integrin, beta 4 -0.0299027
RPL37A ribosomal protein L37a -0.0294609
RPL31 ribosomal protein L31 -0.0291712
RPL12 ribosomal protein L12 -0.029101
SAMD4A sterile alpha motif domain containing 4A -0.0289004
RPS6 ribosomal protein S6 -0.0286625
ZNFX1 zinc finger, NFX1-type containing 1 -0.0283756
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0280545
MYH14 myosin, heavy chain 14, non-muscle -0.0275954
SMAD2 SMAD family member 2 -0.0274554
ARHGAP42 Rho GTPase activating protein 42 -0.0274347
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0272291
PKM pyruvate kinase, muscle -0.027122
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0268395
IFITM3 interferon induced transmembrane protein 3 -0.0263283
PTPRK protein tyrosine phosphatase, receptor type, K -0.0261344
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0260936
RPL18 ribosomal protein L18 -0.0257486
RPLP1 ribosomal protein, large, P1 -0.0256206
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0256098
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0253698
ACTG1 actin gamma 1 -0.0251884
TGFBI transforming growth factor, beta-induced, 68kDa -0.0250462
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0247053
SVIL supervillin -0.0246216
ETV6 ets variant 6 -0.0243442
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0238683
PKP4 plakophilin 4 -0.0238181
DLG1 discs, large homolog 1 (Drosophila) -0.0235509
BRD2 bromodomain containing 2 -0.0233439
POTEF POTE ankyrin domain family, member F -0.0230647
EHBP1 EH domain binding protein 1 -0.0229621
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0228104
CLDN3 claudin 3 -0.0225852
RPS13 ribosomal protein S13 -0.0225672
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0223411
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0220874
FOSL1 FOS-like antigen 1 -0.0220801
IFITM1 interferon induced transmembrane protein 1 -0.0220061
ITCH itchy E3 ubiquitin protein ligase -0.0219748
RPS14 ribosomal protein S14 -0.0219263
C6ORF132 chromosome 6 open reading frame 132 -0.0217544
ADNP activity-dependent neuroprotector homeobox -0.0215439
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0214832
AVL9 AVL9 homolog (S. cerevisiase) -0.0214741