Bosentan (hydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bosentan (hydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bosentan (hydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.190725
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103419
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0524864
RNF145 ring finger protein 145 0.0520722
NUP58 nucleoporin 58 0.051886
GOLGA4 golgin A4 0.049138
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0486442
USP3 ubiquitin specific peptidase 3 0.0482686
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0481129
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0479558
PUM2 pumilio RNA-binding family member 2 0.0452607
WAC WW domain containing adaptor with coiled-coil 0.0444492
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0439872
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0430525
KDM6A lysine (K)-specific demethylase 6A 0.0430127
PDE4B phosphodiesterase 4B, cAMP-specific 0.041106
NAMPT nicotinamide phosphoribosyltransferase 0.0409921
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0403134
ANXA1 annexin A1 0.0399827
GARS1 glycyl-tRNA synthetase 1 0.0394559
EREG epiregulin 0.0381095
KDM3A lysine (K)-specific demethylase 3A 0.0378171
OGA O-GlcNAcase 0.0372322
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0370773
FAR1 fatty acyl CoA reductase 1 0.0368283
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.035464
TOP1 topoisomerase (DNA) I 0.0352349
BBX bobby sox homolog (Drosophila) 0.0352012
KMT2C lysine (K)-specific methyltransferase 2C 0.035162
NCKAP1 NCK-associated protein 1 0.0348596
COG5 component of oligomeric golgi complex 5 0.0344753
RLF rearranged L-myc fusion 0.0334043
STRN3 striatin, calmodulin binding protein 3 0.0332007
PTBP2 polypyrimidine tract binding protein 2 0.0330143
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0321729
DDIT4 DNA-damage-inducible transcript 4 0.0319417
HILPDA hypoxia inducible lipid droplet-associated 0.0313247
NPEPPS aminopeptidase puromycin sensitive 0.0309464
BIRC3 baculoviral IAP repeat containing 3 0.0304567
CHD1 chromodomain helicase DNA binding protein 1 0.0304381
MXI1 MAX interactor 1, dimerization protein 0.0298685
WDR43 WD repeat domain 43 0.029785
RAB6A RAB6A, member RAS oncogene family 0.0297655
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0293693
MARCHF6 membrane associated ring-CH-type finger 6 0.0281705
YTHDC1 YTH domain containing 1 0.0280926
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0279927
HSPA8 heat shock 70kDa protein 8 0.0279631
CDC73 cell division cycle 73 0.0278706
RBM39 RNA binding motif protein 39 0.0276699
ZNF292 zinc finger protein 292 0.0274419
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272392
TOP2B topoisomerase (DNA) II beta 180kDa 0.026969
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0268378
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0267859
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0262064
RUNX2 runt-related transcription factor 2 0.026137
ZFAND3 zinc finger, AN1-type domain 3 0.0260032
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0258269
SFPQ splicing factor proline/glutamine-rich 0.0257246
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.025391
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0251827
CSDE1 cold shock domain containing E1, RNA-binding 0.0246852
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0243906
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0237714
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0231011
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0230214
ESYT2 extended synaptotagmin-like protein 2 0.0229838
TFG TRK-fused gene 0.0229142
ABI1 abl-interactor 1 0.0228048
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0221249
ADAM9 ADAM metallopeptidase domain 9 0.0221206
SLMAP sarcolemma associated protein 0.0217665
EWSR1 EWS RNA-binding protein 1 0.0216628
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0216393
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0215569
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.021546
CCNY cyclin Y 0.0209177
TFRC transferrin receptor 0.0205542
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0205268
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0204359
PNISR PNN-interacting serine/arginine-rich protein 0.0202688
ERRFI1 ERBB receptor feedback inhibitor 1 0.0199411
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.019879
RICTOR RPTOR independent companion of MTOR, complex 2 0.0198782
ADAM17 ADAM metallopeptidase domain 17 0.0198577
IPO7 importin 7 0.0196628
RAD23B RAD23 homolog B (S. cerevisiae) 0.0194753
MATR3 matrin 3 0.0194373
ELP2 elongator acetyltransferase complex subunit 2 0.0193971
CKAP5 cytoskeleton associated protein 5 0.0192383
ANXA5 annexin A5 0.0190086
UBA2 ubiquitin-like modifier activating enzyme 2 0.0189964
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0189865
ARRDC3 arrestin domain containing 3 0.0189468
MED13L mediator complex subunit 13-like 0.018886
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187907
TES testin LIM domain protein 0.0187589
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0184954
ACBD3 acyl-CoA binding domain containing 3 0.0184533

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.183759
HMGA2 high mobility group AT-hook 2 -0.161184
ACTG1 actin gamma 1 -0.153937
EGR1 early growth response 1 -0.147767
EGFR epidermal growth factor receptor -0.117105
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.110782
RAD51B RAD51 paralog B -0.100419
RCOR1 REST corepressor 1 -0.091871
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0907154
VCL vinculin -0.0891418
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0889538
FHIT fragile histidine triad -0.0773692
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0753549
LAMA4 laminin, alpha 4 -0.0747883
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0681231
FLOT1 flotillin 1 -0.0655353
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0650383
CD9 CD9 molecule -0.0617628
CUX1 cut-like homeobox 1 -0.0609166
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0608213
ANXA2 annexin A2 -0.0577734
DOCK5 dedicator of cytokinesis 5 -0.0564656
ATXN1 ataxin 1 -0.0557671
TPT1 tumor protein, translationally-controlled 1 -0.0544234
LAMB3 laminin, beta 3 -0.0539525
EZR ezrin -0.0536192
RPS8 ribosomal protein S8 -0.0529815
FERMT1 fermitin family member 1 -0.0503435
RPLP1 ribosomal protein, large, P1 -0.0496319
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0486202
RPL35A ribosomal protein L35a -0.0483075
MPRIP myosin phosphatase Rho interacting protein -0.0481349
RPS6 ribosomal protein S6 -0.0474027
EMP1 epithelial membrane protein 1 -0.0464372
NCEH1 neutral cholesterol ester hydrolase 1 -0.0462696
MTAP methylthioadenosine phosphorylase -0.0457588
NTSR1 neurotensin receptor 1 (high affinity) -0.0433953
LOC102724023 ES1 protein homolog, mitochondrial -0.0426799
ITPKC inositol-trisphosphate 3-kinase C -0.0418757
CCSER1 coiled-coil serine-rich protein 1 -0.0415016
FHL2 four and a half LIM domains 2 -0.0410482
IER3 immediate early response 3 -0.0408386
RBM25 RNA binding motif protein 25 -0.0398966
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.039619
PTMA prothymosin, alpha -0.0395894
EHBP1 EH domain binding protein 1 -0.039288
CMIP c-Maf inducing protein -0.0391027
CDK13 cyclin-dependent kinase 13 -0.0386063
SEPTIN9 septin 9 -0.0384439
RPS29 ribosomal protein S29 -0.0370426
ANKRD17 ankyrin repeat domain 17 -0.0369737
EXOC4 exocyst complex component 4 -0.036418
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0363937
ACTN4 actinin, alpha 4 -0.035911
PHF14 PHD finger protein 14 -0.0354286
EFNB2 ephrin-B2 -0.0353951
SMAD3 SMAD family member 3 -0.0351727
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0350971
ITGB4 integrin, beta 4 -0.0350436
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0350305
TNS3 tensin 3 -0.0349297
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0348608
BCL2L1 BCL2-like 1 -0.0346394
RPS19 ribosomal protein S19 -0.0343855
TMSB10 thymosin beta 10 -0.0342083
NUP50 nucleoporin 50kDa -0.0341042
RPS12 ribosomal protein S12 -0.0338189
GPC5 glypican 5 -0.0336726
HMGA1 high mobility group AT-hook 1 -0.0332097
JARID2 jumonji, AT rich interactive domain 2 -0.0331797
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0329576
TPM4 tropomyosin 4 -0.0327535
SH3RF2 SH3 domain containing ring finger 2 -0.0326787
AKAP13 A kinase (PRKA) anchor protein 13 -0.032301
RPL32 ribosomal protein L32 -0.0322914
POTEF POTE ankyrin domain family, member F -0.0309841
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0300932
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0296884
PATJ PATJ crumbs cell polarity complex component -0.0292489
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0291675
GATAD2A GATA zinc finger domain containing 2A -0.0287354
TRAF3 TNF receptor-associated factor 3 -0.028305
BPTF bromodomain PHD finger transcription factor -0.0282967
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0280031
PKM pyruvate kinase, muscle -0.0279794
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0279465
ITGA6 integrin, alpha 6 -0.0273081
RPL34 ribosomal protein L34 -0.0260839
LMNA lamin A/C -0.0258547
EXT1 exostosin glycosyltransferase 1 -0.0256185
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0255145
ABR active BCR-related -0.0254787
SCFD1 sec1 family domain containing 1 -0.0253363
RPL37A ribosomal protein L37a -0.0252397
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0251268
MCL1 myeloid cell leukemia 1 -0.0250056
CLIP2 CAP-GLY domain containing linker protein 2 -0.0249802
PCNX4 pecanex 4 -0.0247638
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0244476
SGMS2 sphingomyelin synthase 2 -0.0244174