| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bosentan (hydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bosentan (hydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.0863055 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0817755 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0682529 |
| PTMA | prothymosin, alpha | 0.0607017 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0596127 |
| CAVIN1 | caveolae associated protein 1 | 0.0579125 |
| ATP13A3 | ATPase type 13A3 | 0.0535151 |
| RPS3 | ribosomal protein S3 | 0.0513939 |
| CANX | calnexin | 0.0502431 |
| DST | dystonin | 0.0424426 |
| ADM | adrenomedullin | 0.04064 |
| GOLGA4 | golgin A4 | 0.0405507 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0400939 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0385255 |
| RNF145 | ring finger protein 145 | 0.0383733 |
| KIF5B | kinesin family member 5B | 0.0378987 |
| CLINT1 | clathrin interactor 1 | 0.0354635 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0352904 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0352459 |
| RPL21 | ribosomal protein L21 | 0.0344821 |
| RPS12 | ribosomal protein S12 | 0.0340216 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0337736 |
| RPL26 | ribosomal protein L26 | 0.0337724 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0333255 |
| TNPO1 | transportin 1 | 0.0329332 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.032854 |
| RPL10A | ribosomal protein L10a | 0.0326962 |
| HMGB2 | high mobility group box 2 | 0.03268 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0324431 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0323595 |
| SET | SET nuclear proto-oncogene | 0.0323072 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0321982 |
| RASA2 | RAS p21 protein activator 2 | 0.0306905 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0299892 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0288372 |
| RPL23 | ribosomal protein L23 | 0.0285848 |
| TMF1 | TATA element modulatory factor 1 | 0.0285751 |
| RPS17 | ribosomal protein S17 | 0.0281929 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0270293 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0262926 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0262076 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0261396 |
| MMP12 | matrix metallopeptidase 12 | 0.0260111 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0258413 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0258198 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0256269 |
| USP3 | ubiquitin specific peptidase 3 | 0.025528 |
| OGA | O-GlcNAcase | 0.0245316 |
| WDR43 | WD repeat domain 43 | 0.0245175 |
| TMSB4X | thymosin beta 4, X-linked | 0.0244275 |
| TPM3 | tropomyosin 3 | 0.0243422 |
| NGLY1 | N-glycanase 1 | 0.0242018 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.024121 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0238617 |
| MEIS1 | Meis homeobox 1 | 0.0234419 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0233321 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0233096 |
| SPAG9 | sperm associated antigen 9 | 0.0232593 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0227509 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0226488 |
| RACK1 | receptor for activated C kinase 1 | 0.0226095 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0225296 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0224271 |
| SRP54 | signal recognition particle 54kDa | 0.0223096 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0222324 |
| FAM162A | family with sequence similarity 162, member A | 0.0219505 |
| NBAS | neuroblastoma amplified sequence | 0.021881 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0217941 |
| MMP1 | matrix metallopeptidase 1 | 0.0217169 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0215855 |
| RPS27A | ribosomal protein S27a | 0.0212766 |
| ZNF292 | zinc finger protein 292 | 0.0211744 |
| RPS2 | ribosomal protein S2 | 0.0211378 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0210823 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0207986 |
| MATR3 | matrin 3 | 0.020675 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0204955 |
| CD63 | CD63 molecule | 0.0203977 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0201331 |
| RPS7 | ribosomal protein S7 | 0.0200776 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0199579 |
| UBQLN1 | ubiquilin 1 | 0.019768 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0197359 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0196452 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0194289 |
| PGK1 | phosphoglycerate kinase 1 | 0.0191325 |
| SFXN1 | sideroflexin 1 | 0.019124 |
| SERINC1 | serine incorporator 1 | 0.019079 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0190351 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0190256 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0187589 |
| NUP58 | nucleoporin 58 | 0.0187491 |
| PRPF4B | pre-mRNA processing factor 4B | 0.018704 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0186068 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0185927 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0185923 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0182663 |
| RPL37A | ribosomal protein L37a | 0.0182573 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0180332 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0179884 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.62104 |
| FN1 | fibronectin 1 | -0.184294 |
| VIM | vimentin | -0.0979295 |
| CD44 | CD44 molecule (Indian blood group) | -0.0911819 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0851213 |
| COL1A1 | collagen, type I, alpha 1 | -0.084626 |
| HLA-B | major histocompatibility complex, class I, B | -0.0840176 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0839357 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.083704 |
| NDRG1 | N-myc downstream regulated 1 | -0.0835616 |
| ACTG1 | actin gamma 1 | -0.0773169 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0677683 |
| STC1 | stanniocalcin 1 | -0.0634611 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0600379 |
| NAV1 | neuron navigator 1 | -0.0594121 |
| MYO10 | myosin X | -0.0571181 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0560539 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0551741 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0501272 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0498293 |
| PKM | pyruvate kinase, muscle | -0.0462323 |
| MT2A | metallothionein 2A | -0.0459444 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0454011 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0426766 |
| B2M | beta-2-microglobulin | -0.0409191 |
| EMP1 | epithelial membrane protein 1 | -0.0401603 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0389791 |
| EGR1 | early growth response 1 | -0.0380863 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0380798 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0378232 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0375894 |
| TMSB10 | thymosin beta 10 | -0.0369681 |
| FTL | ferritin, light polypeptide | -0.0360252 |
| IL6 | interleukin 6 | -0.035819 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0354444 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0350577 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0350193 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0340336 |
| VEGFA | vascular endothelial growth factor A | -0.0337276 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0335184 |
| RUNX1 | runt-related transcription factor 1 | -0.0334765 |
| EGFR | epidermal growth factor receptor | -0.0330024 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0319838 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0316298 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.031166 |
| BRD2 | bromodomain containing 2 | -0.0308502 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0304968 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0304372 |
| FUS | FUS RNA binding protein | -0.0299585 |
| LOXL2 | lysyl oxidase-like 2 | -0.0297223 |
| GLIS3 | GLIS family zinc finger 3 | -0.0295477 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0288908 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0285503 |
| IGF2 | insulin-like growth factor 2 | -0.0281989 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0276233 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0275362 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0274793 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0273226 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0268311 |
| OXR1 | oxidation resistance 1 | -0.0267146 |
| VCL | vinculin | -0.0266607 |
| MAP1B | microtubule-associated protein 1B | -0.0266491 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0265952 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0265567 |
| RPLP1 | ribosomal protein, large, P1 | -0.0263921 |
| TAPBP | TAP binding protein (tapasin) | -0.025877 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0257444 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0255011 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0252073 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0251202 |
| WASF2 | WAS protein family, member 2 | -0.0245969 |
| FRMD4A | FERM domain containing 4A | -0.0244847 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0243456 |
| RPS23 | ribosomal protein S23 | -0.0241398 |
| FOXP1 | forkhead box P1 | -0.0239386 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0239039 |
| SMAD3 | SMAD family member 3 | -0.0238969 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0234438 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.023017 |
| CTSB | cathepsin B | -0.0229367 |
| TMEM50A | transmembrane protein 50A | -0.0229127 |
| OSMR | oncostatin M receptor | -0.0228202 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0227524 |
| TXNIP | thioredoxin interacting protein | -0.0227088 |
| CCND1 | cyclin D1 | -0.0226517 |
| FLNA | filamin A, alpha | -0.0226123 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0222072 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.022191 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0220636 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0220184 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0218211 |
| RPS6 | ribosomal protein S6 | -0.0217479 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0217104 |
| GOLGB1 | golgin B1 | -0.0216357 |
| RPS19 | ribosomal protein S19 | -0.0211111 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.021086 |
| POTEF | POTE ankyrin domain family, member F | -0.0206864 |
| TPM1 | tropomyosin 1 (alpha) | -0.0205143 |
| UBC | ubiquitin C | -0.0204459 |
| AHNAK | AHNAK nucleoprotein | -0.0204362 |
