| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/104865 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Bosentan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC150 | coiled-coil domain containing 150 | 1.41 |
| TMC4 | transmembrane channel-like 4 | 1.27 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 1.12 |
| CFAP57 | cilia and flagella associated protein 57 | 1.12 |
| LIN7A | lin-7 homolog A (C. elegans) | 1.06 |
| PKM | pyruvate kinase, muscle | 0.86 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.76 |
| ACTBL2 | actin, beta-like 2 | 0.69 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | 0.65 |
| IER2 | immediate early response 2 | 0.62 |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 | 0.55 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.53 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.52 |
| SNX5 | sorting nexin 5 | 0.48 |
| POTEE | POTE ankyrin domain family, member E | 0.47 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | 0.46 |
| ZNF714 | zinc finger protein 714 | 0.46 |
| ZNF777 | zinc finger protein 777 | 0.46 |
| ZBTB7B | zinc finger and BTB domain containing 7B | 0.46 |
| RPL31 | ribosomal protein L31 | 0.43 |
| RPL37A | ribosomal protein L37a | 0.42 |
| FAM189B | family with sequence similarity 189, member B | 0.42 |
| XDH | xanthine dehydrogenase | 0.42 |
| MYNN | myoneurin | 0.41 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | 0.4 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | 0.4 |
| ZNF22 | zinc finger protein 22 | 0.39 |
| TMEM14C | transmembrane protein 14C | 0.38 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.37 |
| ERICH5 | glutamate-rich 5 | 0.37 |
| RHOT2 | ras homolog family member T2 | 0.36 |
| CCNYL1 | cyclin Y-like 1 | 0.35 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.35 |
| ZNF175 | zinc finger protein 175 | 0.35 |
| ZNF675 | zinc finger protein 675 | 0.35 |
| KIAA1210 | KIAA1210 | 0.35 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.34 |
| NAF1 | nuclear assembly factor 1 ribonucleoprotein | 0.34 |
| USP16 | ubiquitin specific peptidase 16 | 0.34 |
| RPL11 | ribosomal protein L11 | 0.34 |
| ATP5F1C | ATP synthase F1 subunit gamma | 0.33 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.33 |
| HECA | headcase homolog (Drosophila) | 0.33 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.33 |
| VIM | vimentin | 0.32 |
| SFXN4 | sideroflexin 4 | 0.32 |
| RPA1 | replication protein A1, 70kDa | 0.32 |
| ELK1 | ELK1, member of ETS oncogene family | 0.32 |
| TRIM29 | tripartite motif containing 29 | 0.32 |
| NUDT8 | nudix (nucleoside diphosphate linked moiety X)-type motif 8 | 0.32 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.32 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.32 |
| TRMT61A | tRNA methyltransferase 61A | 0.32 |
| YTHDC1 | YTH domain containing 1 | 0.32 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.32 |
| ABHD17C | abhydrolase domain containing 17C | 0.32 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.31 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.31 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | 0.31 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.3 |
| MRPL4 | mitochondrial ribosomal protein L4 | 0.3 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.3 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.3 |
| PCYT1B | phosphate cytidylyltransferase 1, choline, beta | 0.3 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.3 |
| MED30 | mediator complex subunit 30 | 0.3 |
| SPAG17 | sperm associated antigen 17 | 0.3 |
| DBN1 | drebrin 1 | 0.3 |
| ZNF823 | zinc finger protein 823 | 0.29 |
| TJP1 | tight junction protein 1 | 0.29 |
| NFYA | nuclear transcription factor Y, alpha | 0.29 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase | 0.29 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.29 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.29 |
| ADAR | adenosine deaminase, RNA-specific | 0.29 |
| RANBP17 | RAN binding protein 17 | 0.29 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 0.29 |
| TYMS | thymidylate synthetase | 0.29 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.28 |
| ZNF226 | zinc finger protein 226 | 0.28 |
| ZFHX4 | zinc finger homeobox 4 | 0.28 |
| MGA | MGA, MAX dimerization protein | 0.28 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.28 |
| ZBTB44 | zinc finger and BTB domain containing 44 | 0.28 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | 0.28 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | 0.28 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | 0.28 |
| TRAPPC13 | trafficking protein particle complex 13 | 0.28 |
| TMEM222 | transmembrane protein 222 | 0.28 |
| F8A1 | coagulation factor VIII-associated 1 | 0.27 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | 0.27 |
| SURF2 | surfeit 2 | 0.27 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.27 |
| THOC3 | THO complex 3 | 0.27 |
| DESI1 | desumoylating isopeptidase 1 | 0.27 |
| DXO | decapping exoribonuclease | 0.27 |
| AARS | alanyl-tRNA synthetase | 0.26 |
| BET1 | Bet1 golgi vesicular membrane trafficking protein | 0.26 |
| CAB39L | calcium binding protein 39-like | 0.26 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | -3.54 |
| SH2B3 | SH2B adaptor protein 3 | -0.84 |
| TRIM62 | tripartite motif containing 62 | -0.69 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.63 |
| GAB1 | GRB2-associated binding protein 1 | -0.62 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -0.6 |
| ENO1 | enolase 1, (alpha) | -0.58 |
| TC2N | tandem C2 domains, nuclear | -0.54 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.53 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.5 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.49 |
| SBSN | suprabasin | -0.49 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | -0.47 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.47 |
| COL1A2 | collagen, type I, alpha 2 | -0.46 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.44 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | -0.44 |
| EPHX4 | epoxide hydrolase 4 | -0.44 |
| FAT3 | FAT atypical cadherin 3 | -0.43 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | -0.42 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.42 |
| ZNF564 | zinc finger protein 564 | -0.41 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.41 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.4 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.39 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.39 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.39 |
| MIER2 | mesoderm induction early response 1, family member 2 | -0.39 |
| CCN2 | cellular communication network factor 2 | -0.39 |
| FBXO33 | F-box protein 33 | -0.38 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.37 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.37 |
| SCAMP4 | secretory carrier membrane protein 4 | -0.37 |
| FBN3 | fibrillin 3 | -0.36 |
| TPST2 | tyrosylprotein sulfotransferase 2 | -0.35 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.35 |
| ASB13 | ankyrin repeat and SOCS box containing 13 | -0.35 |
| NFYB | nuclear transcription factor Y, beta | -0.35 |
| SLC38A9 | solute carrier family 38, member 9 | -0.35 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.34 |
| PLEK | pleckstrin | -0.34 |
| CYB5D2 | cytochrome b5 domain containing 2 | -0.34 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | -0.34 |
| PSAP | prosaposin | -0.34 |
| TUB | tubby bipartite transcription factor | -0.34 |
| SARDH | sarcosine dehydrogenase | -0.34 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.34 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | -0.33 |
| MRVI1 | murine retrovirus integration site 1 homolog | -0.33 |
| SERINC5 | serine incorporator 5 | -0.33 |
| TRAIP | TRAF interacting protein | -0.33 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | -0.33 |
| VSIG10 | V-set and immunoglobulin domain containing 10 | -0.33 |
| CCDC82 | coiled-coil domain containing 82 | -0.33 |
| IFT43 | intraflagellar transport 43 | -0.32 |
| UBXN8 | UBX domain protein 8 | -0.32 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.32 |
| TBC1D32 | TBC1 domain family, member 32 | -0.32 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.32 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.31 |
| DYSF | dysferlin | -0.31 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.31 |
| KIF26A | kinesin family member 26A | -0.31 |
| KCTD17 | potassium channel tetramerization domain containing 17 | -0.31 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | -0.31 |
| SAP30L | SAP30-like | -0.31 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.31 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -0.3 |
| TM2D3 | TM2 domain containing 3 | -0.3 |
| MKRN4P | makorin ring finger protein 4, pseudogene | -0.3 |
| HSBP1 | heat shock factor binding protein 1 | -0.3 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.3 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -0.3 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.3 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.3 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.3 |
| DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | -0.29 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.29 |
| IFNGR1 | interferon gamma receptor 1 | -0.29 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | -0.29 |
| TPM1 | tropomyosin 1 (alpha) | -0.29 |
| FBXO44 | F-box protein 44 | -0.29 |
| FN1 | fibronectin 1 | -0.29 |
| ZNF296 | zinc finger protein 296 | -0.28 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.28 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.28 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.28 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.28 |
| SLC25A30 | solute carrier family 25, member 30 | -0.28 |
| ZNF805 | zinc finger protein 805 | -0.28 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.28 |
| SPRYD3 | SPRY domain containing 3 | -0.28 |
| PLA2G12A | phospholipase A2, group XIIA | -0.28 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.27 |
| COQ5 | coenzyme Q5 homolog, methyltransferase (S. cerevisiae) | -0.27 |
| CHMP3 | charged multivesicular body protein 3 | -0.27 |
| HDAC7 | histone deacetylase 7 | -0.27 |
| ENDOV | endonuclease V | -0.27 |
| CCDC167 | coiled-coil domain containing 167 | -0.27 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.27 |
