Bosutinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5328940
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Genes

199 proteins with high or low expression in Bosutinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
APOB apolipoprotein B 3.97
TMEM59 transmembrane protein 59 3.96
LAPTM4A lysosomal protein transmembrane 4 alpha 3.56
ITM2B integral membrane protein 2B 3.48
NDFIP1 Nedd4 family interacting protein 1 3.18
ITM2C integral membrane protein 2C 2.96
NCOA4 nuclear receptor coactivator 4 2.69
FGFBP1 fibroblast growth factor binding protein 1 2.57
IFNGR1 interferon gamma receptor 1 2.44
C4BPA complement component 4 binding protein, alpha 2.41
APOE apolipoprotein E 2.41
NBR1 neighbor of BRCA1 gene 1 2.37
LRP10 low density lipoprotein receptor-related protein 10 2.36
SEMG1 semenogelin I 2.18
NDFIP2 Nedd4 family interacting protein 2 2.15
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.97
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.96
PCSK9 proprotein convertase subtilisin/kexin type 9 1.96
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.86
TMEM248 transmembrane protein 248 1.86
AREG amphiregulin 1.82
ACVR1B activin A receptor, type IB 1.81
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.77
DNAH12 dynein, axonemal, heavy chain 12 1.76
APP amyloid beta (A4) precursor protein 1.76
RNF149 ring finger protein 149 1.75
CLK1 CDC-like kinase 1 1.72
F5 coagulation factor V (proaccelerin, labile factor) 1.69
APLP2 amyloid beta (A4) precursor-like protein 2 1.69
RNF130 ring finger protein 130 1.66
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 1.66
HGFAC HGF activator 1.62
BMPR1B bone morphogenetic protein receptor, type IB 1.57
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.55
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.54
PSAP prosaposin 1.47
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.47
H1-0 H1.0 linker histone 1.47
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.47
ADGRG1 adhesion G protein-coupled receptor G1 1.46
CALCOCO2 calcium binding and coiled-coil domain 2 1.41
SQSTM1 sequestosome 1 1.4
MSMO1 methylsterol monooxygenase 1 1.4
INPP5J inositol polyphosphate-5-phosphatase J 1.4
PTPRS protein tyrosine phosphatase, receptor type, S 1.39
TRIM2 tripartite motif containing 2 1.39
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.37
UGCG UDP-glucose ceramide glucosyltransferase 1.36
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.34
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.33
CD63 CD63 molecule 1.33
BMPR1A bone morphogenetic protein receptor, type IA 1.33
CCDC158 coiled-coil domain containing 158 1.33
FGB fibrinogen beta chain 1.33
MVK mevalonate kinase 1.32
MFGE8 milk fat globule-EGF factor 8 protein 1.31
IDI1 isopentenyl-diphosphate delta isomerase 1 1.31
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.3
SQLE squalene epoxidase 1.28
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.28
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.27
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.26
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.26
SERINC1 serine incorporator 1 1.26
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.22
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.21
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.19
COL14A1 collagen, type XIV, alpha 1 1.19
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.17
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.16
TMUB1 transmembrane and ubiquitin-like domain containing 1 1.14
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 1.14
OSMR oncostatin M receptor 1.14
CERK ceramide kinase 1.14
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 1.14
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.12
PLD3 phospholipase D family, member 3 1.12
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.11
SDCBP syndecan binding protein (syntenin) 1.11
GRN granulin 1.11
LDLR low density lipoprotein receptor 1.1
FAT1 FAT atypical cadherin 1 1.09
METTL7A methyltransferase like 7A 1.07
GINM1 glycoprotein integral membrane 1 1.07
TIMP3 TIMP metallopeptidase inhibitor 3 1.06
VTN vitronectin 1.05
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.05
SLC38A2 solute carrier family 38, member 2 1.05
CD81 CD81 molecule 1.04
LPIN1 lipin 1 1.04
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.02
THAP9 THAP domain containing 9 1.01
GSS glutathione synthetase 1.01
BHLHE40 basic helix-loop-helix family, member e40 1.01
CLSTN3 calsyntenin 3 1.01
HSPG2 heparan sulfate proteoglycan 2 1.0
FBXL2 F-box and leucine-rich repeat protein 2 0.99
IL10RB interleukin 10 receptor, beta 0.98
CLDND1 claudin domain containing 1 0.98

low expression

Symbol Name Standardized Value
DUOX1 dual oxidase 1 -4.06
ZMYND19 zinc finger, MYND-type containing 19 -2.2
RRM2 ribonucleotide reductase M2 -2.07
CCNA1 cyclin A1 -2.05
JPT1 Jupiter microtubule associated homolog 1 -2.0
UBE2C ubiquitin-conjugating enzyme E2C -1.96
PCLAF PCNA clamp associated factor -1.83
CCNA2 cyclin A2 -1.75
CDC20 cell division cycle 20 -1.75
DPY19L2 dpy-19-like 2 (C. elegans) -1.73
RESF1 retroelement silencing factor 1 -1.71
CLSPN claspin -1.69
CDCA3 cell division cycle associated 3 -1.61
CDCA5 cell division cycle associated 5 -1.6
CCNB1 cyclin B1 -1.58
DEPDC1 DEP domain containing 1 -1.58
E2F2 E2F transcription factor 2 -1.54
MCM10 minichromosome maintenance complex component 10 -1.52
CCNE2 cyclin E2 -1.51
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.5
ARHGAP11A Rho GTPase activating protein 11A -1.48
DONSON downstream neighbor of SON -1.48
SATB2 SATB homeobox 2 -1.48
ANLN anillin, actin binding protein -1.44
EXO1 exonuclease 1 -1.41
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -1.4
WDR76 WD repeat domain 76 -1.38
USP37 ubiquitin specific peptidase 37 -1.38
PIMREG PICALM interacting mitotic regulator -1.36
SGO1 shugoshin 1 -1.35
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.34
BCAR3 breast cancer anti-estrogen resistance 3 -1.31
MLPH melanophilin -1.31
TACC3 transforming, acidic coiled-coil containing protein 3 -1.29
SYTL3 synaptotagmin-like 3 -1.28
CDC7 cell division cycle 7 -1.24
GTSE1 G-2 and S-phase expressed 1 -1.24
DBF4 DBF4 zinc finger -1.22
TPX2 TPX2, microtubule-associated -1.22
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.21
KIF20B kinesin family member 20B -1.21
CDC25B cell division cycle 25B -1.21
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.2
ZFP36L1 ZFP36 ring finger protein-like 1 -1.18
TRAIP TRAF interacting protein -1.18
TOP2A topoisomerase (DNA) II alpha 170kDa -1.17
CDC6 cell division cycle 6 -1.17
KIF18B kinesin family member 18B -1.17
FANCM Fanconi anemia, complementation group M -1.17
KIF22 kinesin family member 22 -1.16
SACK1D scaffolding CK1 anchoring protein D -1.16
PLK1 polo-like kinase 1 -1.16
LRR1 leucine rich repeat protein 1 -1.16
ENO1 enolase 1, (alpha) -1.15
TK1 thymidine kinase 1, soluble -1.15
DIAPH3 diaphanous-related formin 3 -1.13
RAD51AP1 RAD51 associated protein 1 -1.12
MTFR2 mitochondrial fission regulator 2 -1.12
GMNN geminin, DNA replication inhibitor -1.12
AKAP6 A kinase (PRKA) anchor protein 6 -1.11
CCNB2 cyclin B2 -1.11
GREB1 growth regulation by estrogen in breast cancer 1 -1.1
ETV5 ets variant 5 -1.1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.09
NUSAP1 nucleolar and spindle associated protein 1 -1.09
KIFC1 kinesin family member C1 -1.09
KIF11 kinesin family member 11 -1.08
ZNF189 zinc finger protein 189 -1.08
TNS4 tensin 4 -1.07
BAIAP2 BAI1-associated protein 2 -1.07
NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.07
AMD1 adenosylmethionine decarboxylase 1 -1.06
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -1.06
BARD1 BRCA1 associated RING domain 1 -1.06
CENPF centromere protein F, 350/400kDa -1.06
KNL1 kinetochore scaffold 1 -1.06
CBX2 chromobox homolog 2 -1.05
POLQ polymerase (DNA directed), theta -1.04
MIS18BP1 MIS18 binding protein 1 -1.04
ZFAND5 zinc finger, AN1-type domain 5 -1.04
CENPE centromere protein E, 312kDa -1.04
DNA2 DNA replication helicase/nuclease 2 -1.03
MGLL monoglyceride lipase -1.03
SASS6 spindle assembly 6 homolog (C. elegans) -1.03
PTTG1 pituitary tumor-transforming 1 -1.02
ZNRD1 zinc ribbon domain containing 1 -1.02
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -1.02
SLBP stem-loop binding protein -1.02
JAK2 Janus kinase 2 -1.01
FBXO5 F-box protein 5 -1.01
PRR11 proline rich 11 -1.01
JUNB jun B proto-oncogene -1.0
UBE2S ubiquitin-conjugating enzyme E2S -0.99
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.99
MUTYH mutY homolog -0.98
ECT2 epithelial cell transforming 2 -0.98
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.97
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -0.97
BTG3 BTG family, member 3 -0.97
CCNE1 cyclin E1 -0.97