Botulism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located_in neuromuscular junction, resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. (Human Disease Ontology, DOID_11976)
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Genes

137 genes co-occuring with the disease Botulism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 3.157
SNAP25 synaptosomal-associated protein, 25kDa 3.054
DENND11 DENN domain containing 11 3.052
SYT2 synaptotagmin II 3.041
SV2A synaptic vesicle glycoprotein 2A 2.946
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 2.944
SV2C synaptic vesicle glycoprotein 2C 2.898
GPA33 glycoprotein A33 (transmembrane) 2.661
SYT1 synaptotagmin I 2.572
SCAND1 SCAN domain containing 1 2.535
SV2B synaptic vesicle glycoprotein 2B 2.513
BRD3 bromodomain containing 3 2.491
STX1A syntaxin 1A (brain) 2.443
ALLC allantoicase 2.428
PEX19 peroxisomal biogenesis factor 19 2.294
GP2 glycoprotein 2 (zymogen granule membrane) 2.222
VAMP4 vesicle-associated membrane protein 4 2.215
VAMP5 vesicle-associated membrane protein 5 2.141
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.122
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.093
TUSC3 tumor suppressor candidate 3 2.031
MUSK muscle, skeletal, receptor tyrosine kinase 1.953
ALB albumin 1.943
TAC1 tachykinin, precursor 1 1.908
SNAP23 synaptosomal-associated protein, 23kDa 1.882
STX1B syntaxin 1B 1.878
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.843
STX2 syntaxin 2 1.814
TXN thioredoxin 1.742
SYT3 synaptotagmin III 1.687
RAPSN receptor-associated protein of the synapse 1.681
COPS9 COP9 signalosome subunit 9 1.641
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 1.585
CTRB2 chymotrypsinogen B2 1.58
CTRB1 chymotrypsinogen B1 1.574
DOK7 docking protein 7 1.548
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.547
CPE carboxypeptidase E 1.538
VAMP3 vesicle-associated membrane protein 3 1.532
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 1.529
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.522
HMGN4 high mobility group nucleosomal binding domain 4 1.51
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 1.502
NSF N-ethylmaleimide-sensitive factor 1.491
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.469
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.431
SVOP SV2 related protein homolog (rat) 1.394
ANTXR2 anthrax toxin receptor 2 1.384
CDR2 cerebellar degeneration-related protein 2, 62kDa 1.382
TYRP1 tyrosinase-related protein 1 1.36
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 1.353
EFS embryonal Fyn-associated substrate 1.344
ERVW-1 endogenous retrovirus group W, member 1 1.341
NKX2-1 NK2 homeobox 1 1.336
VAMP7 vesicle-associated membrane protein 7 1.332
LRP4 low density lipoprotein receptor-related protein 4 1.318
BCHE butyrylcholinesterase 1.313
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.305
DPH7 diphthamide biosynthesis 7 1.3
CHAT choline O-acetyltransferase 1.297
EEF2 eukaryotic translation elongation factor 2 1.287
CASS4 Cas scaffolding protein family member 4 1.286
RABGGTA Rab geranylgeranyltransferase, alpha subunit 1.28
DNAL1 dynein, axonemal, light chain 1 1.273
MRAP melanocortin 2 receptor accessory protein 1.269
ADCY10 adenylate cyclase 10 (soluble) 1.267
RAB5A RAB5A, member RAS oncogene family 1.264
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.262
STX4 syntaxin 4 1.262
CHRND cholinergic receptor, nicotinic, delta (muscle) 1.26
NGF nerve growth factor (beta polypeptide) 1.25
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 1.248
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.242
CKMT1B creatine kinase, mitochondrial 1B 1.241
CKB creatine kinase, brain 1.238
CPB2 carboxypeptidase B2 (plasma) 1.238
CKM creatine kinase, muscle 1.236
INS insulin 1.209
TNF tumor necrosis factor 1.206
BDNF brain-derived neurotrophic factor 1.204
ERV3-1 endogenous retrovirus group 3, member 1 1.203
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.202
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.197
TMPRSS15 transmembrane protease, serine 15 1.192
MB myoglobin 1.189
GMEB1 glucocorticoid modulatory element binding protein 1 1.188
IZUMO1 izumo sperm-egg fusion 1 1.182
KNG1 kininogen 1 1.175
RNGTT RNA guanylyltransferase and 5'-phosphatase 1.173
ACHE acetylcholinesterase (Yt blood group) 1.162
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 1.158
CD4 CD4 molecule 1.154
HACD2 3-hydroxyacyl-CoA dehydratase 2 1.154
GMPPB GDP-mannose pyrophosphorylase B 1.142
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 1.142
SUCO SUN domain containing ossification factor 1.142
AGRN agrin 1.141
IL6 interleukin 6 1.139
CRP C-reactive protein, pentraxin-related 1.136
RAD51 RAD51 recombinase 1.128
BASP1 brain abundant, membrane attached signal protein 1 1.121
ING2 inhibitor of growth family, member 2 1.12
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.119
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.119
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.119
HCFC2 host cell factor C2 1.115
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.109
ANTXR1 anthrax toxin receptor 1 1.107
CPB1 carboxypeptidase B1 (tissue) 1.104
LGALS4 lectin, galactoside-binding, soluble, 4 1.09
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.085
EEA1 early endosome antigen 1 1.083
IL10 interleukin 10 1.082
SYN1 synapsin I 1.079
IL1B interleukin 1, beta 1.072
GYPA glycophorin A (MNS blood group) 1.068
IGHMBP2 immunoglobulin mu binding protein 2 1.06
CDC42 cell division cycle 42 1.057
IFNG interferon, gamma 1.055
TJAP1 tight junction associated protein 1 (peripheral) 1.055
VAMP8 vesicle-associated membrane protein 8 1.05
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.041
PLA2G4E phospholipase A2, group IVE 1.041
LGALS2 lectin, galactoside-binding, soluble, 2 1.038
DENND2B DENN domain containing 2B 1.035
RARA retinoic acid receptor, alpha 1.033
CD8A CD8a molecule 1.03
PXDNL peroxidasin-like 1.027
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.026
PXDN peroxidasin 1.025
TLR5 toll-like receptor 5 1.022
GDNF glial cell derived neurotrophic factor 1.02
NASP nuclear autoantigenic sperm protein (histone-binding) 1.018
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 1.009
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 1.007
STX3 syntaxin 3 1.006
ING3 inhibitor of growth family, member 3 1.005