Brain Atrophy Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Partial or complete wasting (loss) of brain tissue that was once present. (Human Phenotype Ontology, HP_0012444)
External Link https://www.disgenet.org/browser/0/1/0/C4551584
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Genes

175 genes associated with the disease Brain Atrophy in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE angiotensin I converting enzyme
ADAR adenosine deaminase, RNA-specific
ADAT3 adenosine deaminase, tRNA-specific 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGPS alkylglycerone phosphate synthase
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASPA aspartoacylase
ATP13A2 ATPase type 13A2
ATXN1 ataxin 1
ATXN3 ataxin 3
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
BIN1 bridging integrator 1
C9ORF72 chromosome 9 open reading frame 72
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPN1 calpain 1, (mu/I) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD163 CD163 molecule
CD2AP CD2-associated protein
CD33 CD33 molecule
CDK5 cyclin-dependent kinase 5
CDKL5 cyclin-dependent kinase-like 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHMP2B charged multivesicular body protein 2B
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CLU clusterin
CRP C-reactive protein, pentraxin-related
CRYGD crystallin, gamma D
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DPYS dihydropyrimidinase
DRD2 dopamine receptor D2
ENO2 enolase 2 (gamma, neuronal)
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FBLN1 fibulin 1
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGFR3 fibroblast growth factor receptor 3
FMR1 fragile X mental retardation 1
FTO fat mass and obesity associated
GCA grancalcin, EF-hand calcium binding protein
GGT1 gamma-glutamyltransferase 1
GGTLC3 gamma-glutamyltransferase light chain 3
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRID2 glutamate receptor, ionotropic, delta 2
GRM7 glutamate receptor, metabotropic 7
GRN granulin
GSTP1 glutathione S-transferase pi 1
HDAC3 histone deacetylase 3
HFE hemochromatosis
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HPGDS hematopoietic prostaglandin D synthase
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6 interleukin 6
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIF5B kinesin family member 5B
KIF7 kinesin family member 7
KL klotho
LAMC2 laminin, gamma 2
LBR lamin B receptor
LGI1 leucine-rich, glioma inactivated 1
LTA lymphotoxin alpha
MAPT microtubule-associated protein tau
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED20 mediator complex subunit 20
MPO myeloperoxidase
NAGLU N-acetylglucosaminidase, alpha
NANP N-acetylneuraminic acid phosphatase
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAXE NAD(P)HX epimerase
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NECAP1 NECAP endocytosis associated 1
NEFL neurofilament, light polypeptide
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NHLRC2 NHL repeat containing 2
NINL ninein-like
NRGN neurogranin (protein kinase C substrate, RC3)
NUCLEOLIN nucleolin multifunctional protein
P4HB prolyl 4-hydroxylase, beta polypeptide
PADI1 peptidyl arginine deiminase, type I
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDIA2 protein disulfide isomerase family A, member 2
PGAP1 post-GPI attachment to proteins 1
PGAP2 post-GPI attachment to proteins 2
PICALM phosphatidylinositol binding clathrin assembly protein
PLP1 proteolipid protein 1
PLXNA2 plexin A2
PODXL podocalyxin-like
POLG polymerase (DNA directed), gamma
PRSS3 protease, serine, 3
PSEN1 presenilin 1
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PVR poliovirus receptor
RAG1 recombination activating gene 1
RARS1 arginyl-tRNA synthetase 1
RBM45 RNA binding motif protein 45
RNASEH2A ribonuclease H2, subunit A
RNASEH2B ribonuclease H2, subunit B
RNASEH2C ribonuclease H2, subunit C
SAMHD1 SAM domain and HD domain 1
SCN2A sodium channel, voltage gated, type II alpha subunit
SERAC1 serine active site containing 1
SETBP1 SET binding protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST7 suppression of tumorigenicity 7
SYNJ1 synaptojanin 1
TANGO2 transport and golgi organization 2 homolog (Drosophila)
TARDBP TAR DNA binding protein
TBCK TBC1 domain containing kinase
TGFB1 transforming growth factor, beta 1
TGM6 transglutaminase 6
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIMP4 TIMP metallopeptidase inhibitor 4
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TMEM106B transmembrane protein 106B
TNF tumor necrosis factor
TPP1 tripeptidyl peptidase I
TPRKB TP53RK binding protein
TPSG1 tryptase gamma 1
TREM2 triggering receptor expressed on myeloid cells 2
TREX1 three prime repair exonuclease 1
TRMT5 tRNA methyltransferase 5
TSPO translocator protein (18kDa)
TTR transthyretin
USP9X ubiquitin specific peptidase 9, X-linked
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
WDR45 WD repeat domain 45
WDR73 WD repeat domain 73
WDR81 WD repeat domain 81
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
YME1L1 YME1-like 1 ATPase
ZNF335 zinc finger protein 335
ZNF592 zinc finger protein 592