Brain Ischemia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0007786
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Genes

345 genes associated with the disease Brain Ischemia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ACE angiotensin I converting enzyme
ACTB actin, beta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AGER advanced glycosylation end product-specific receptor
AGTR1 angiotensin II receptor, type 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIF1 allograft inflammatory factor 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ANGPT2 angiopoietin 2
ANXA1 annexin A1
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
AQP4 aquaporin 4
AQP5 aquaporin 5
AQP8 aquaporin 8
ASIC1 acid sensing (proton gated) ion channel 1
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BMP6 bone morphogenetic protein 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG2 BTG family, member 2
C2ORF61 chromosome 2 open reading frame 61
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAST calpastatin
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDK5 cyclin-dependent kinase 5
CDNF cerebral dopamine neurotrophic factor
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHMP2B charged multivesicular body protein 2B
CHRM1 cholinergic receptor, muscarinic 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN5 claudin 5
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CP ceruloplasmin (ferroxidase)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSPG4 chondroitin sulfate proteoglycan 4
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSB cathepsin B
CTSC cathepsin C
CTSL cathepsin L
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCR3 chemokine (C-X-C motif) receptor 3
CYCS cytochrome c, somatic
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCX doublecortin
DDIT3 DNA-damage-inducible transcript 3
DIABLO diablo, IAP-binding mitochondrial protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG4 discs, large homolog 4 (Drosophila)
DMRT1 doublesex and mab-3 related transcription factor 1
DNM1L dynamin 1-like
DPYSL2 dihydropyrimidinase-like 2
DRD2 dopamine receptor D2
DUSP6 dual specificity phosphatase 6
DYNLL1 dynein, light chain, LC8-type 1
EDN1 endothelin 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF3E eukaryotic translation initiation factor 3, subunit E
EMD emerin
ENDOG endonuclease G
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR2 estrogen receptor 2 (ER beta)
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F5 coagulation factor V (proaccelerin, labile factor)
FAIM2 Fas apoptotic inhibitory molecule 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGA fibrinogen alpha chain
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FOXO1 forkhead box O1
FSD1 fibronectin type III and SPRY domain containing 1
FSD1L fibronectin type III and SPRY domain containing 1-like
G6PD glucose-6-phosphate dehydrogenase
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GC group-specific component (vitamin D binding protein)
GET1 guided entry of tail-anchored proteins factor 1
GFAP glial fibrillary acidic protein
GFRA1 GDNF family receptor alpha 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLP1R glucagon-like peptide 1 receptor
GLUD1 glutamate dehydrogenase 1
GOLGA6A golgin A6 family, member A
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GRAP2 GRB2-related adaptor protein 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRM2 glutamate receptor, metabotropic 2
GSK3B glycogen synthase kinase 3 beta
HAP1 huntingtin-associated protein 1
HDAC9 histone deacetylase 9
HDLBP high density lipoprotein binding protein
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HVCN1 hydrogen voltage gated channel 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10RB interleukin 10 receptor, beta
IL12RB1 interleukin 12 receptor, beta 1
IL15 interleukin 15
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INTS6 integrator complex subunit 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
JUN jun proto-oncogene
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDR kinase insert domain receptor
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
KNG1 kininogen 1
LAMC2 laminin, gamma 2
LEMD3 LEM domain containing 3
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LONP1 lon peptidase 1, mitochondrial
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MBL2 mannose-binding lectin (protein C) 2, soluble
MBTPS1 membrane-bound transcription factor peptidase, site 1
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MDK midkine (neurite growth-promoting factor 2)
MFN2 mitofusin 2
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPRIP myosin phosphatase Rho interacting protein
MSI1 musashi RNA-binding protein 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAIP NLR family, apoptosis inhibitory protein
NAMPT nicotinamide phosphoribosyltransferase
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLN neurolysin (metallopeptidase M3 family)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NPTXR neuronal pentraxin receptor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRF1 nuclear respiratory factor 1
NRG1 neuregulin 1
NTN1 netrin 1
NUCB2 nucleobindin 2
OCLN occludin
OPRM1 opioid receptor, mu 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PAEP progestagen-associated endometrial protein
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PGP phosphoglycolate phosphatase
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PMM1 phosphomannomutase 1
PMM2 phosphomannomutase 2
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX6 peroxiredoxin 6
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRNP prion protein
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRRT2 proline-rich transmembrane protein 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RB1 retinoblastoma 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RET ret proto-oncogene
RETN resistin
RIPK3 receptor-interacting serine-threonine kinase 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
S100B S100 calcium binding protein B
SCN5A sodium channel, voltage gated, type V alpha subunit
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN2 sestrin 2
SGK1 serum/glucocorticoid regulated kinase 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STC1 stanniocalcin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TEK TEK tyrosine kinase, endothelial
TF transferrin
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
TICAM1 toll-like receptor adaptor molecule 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TJP1 tight junction protein 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLX2 T-cell leukemia homeobox 2
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TP53 tumor protein p53
TRIM69 tripartite motif containing 69
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSPAN33 tetraspanin 33
TTR transthyretin
TXN thioredoxin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZC3H12A zinc finger CCCH-type containing 12A