| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/57030 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Brequinar relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP53I3 | tumor protein p53 inducible protein 3 | 3.68 |
| TP53 | tumor protein p53 | 3.38 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 2.61 |
| LAMA3 | laminin, alpha 3 | 1.84 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.77 |
| SMTN | smoothelin | 1.73 |
| EPN3 | epsin 3 | 1.66 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 1.64 |
| E2F7 | E2F transcription factor 7 | 1.62 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 1.59 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 1.51 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 1.51 |
| POLH | polymerase (DNA directed), eta | 1.5 |
| FDXR | ferredoxin reductase | 1.49 |
| FAS | Fas cell surface death receptor | 1.48 |
| ARG2 | arginase 2 | 1.43 |
| CCND3 | cyclin D3 | 1.41 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 1.39 |
| IKBIP | IKBKB interacting protein | 1.36 |
| RINL | Ras and Rab interactor-like | 1.35 |
| YPEL5 | yippee-like 5 (Drosophila) | 1.35 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | 1.35 |
| DGKA | diacylglycerol kinase, alpha 80kDa | 1.33 |
| RAET1G | retinoic acid early transcript 1G | 1.33 |
| CCNE1 | cyclin E1 | 1.3 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 1.27 |
| LAMB2 | laminin, beta 2 (laminin S) | 1.27 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 1.27 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 1.26 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 1.25 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1.23 |
| CPA4 | carboxypeptidase A4 | 1.21 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 1.2 |
| SYTL1 | synaptotagmin-like 1 | 1.18 |
| SULF2 | sulfatase 2 | 1.18 |
| COQ8A | coenzyme Q8A | 1.16 |
| ZNF503 | zinc finger protein 503 | 1.15 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 1.13 |
| THAP9 | THAP domain containing 9 | 1.12 |
| ZMAT3 | zinc finger, matrin-type 3 | 1.12 |
| SYBU | syntabulin (syntaxin-interacting) | 1.11 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 1.11 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 1.11 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.1 |
| MORC4 | MORC family CW-type zinc finger 4 | 1.1 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 1.09 |
| PLIN2 | perilipin 2 | 1.09 |
| CCN1 | cellular communication network factor 1 | 1.08 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 1.08 |
| JUN | jun proto-oncogene | 1.08 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.08 |
| SFN | stratifin | 1.07 |
| RRN3 | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) | 1.07 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 1.07 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 1.06 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 1.05 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 1.04 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 1.04 |
| TEP1 | telomerase-associated protein 1 | 1.04 |
| EPS8L2 | EPS8-like 2 | 1.03 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 1.02 |
| PDLIM3 | PDZ and LIM domain 3 | 1.01 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 1.01 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 1.0 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 1.0 |
| CEP68 | centrosomal protein 68kDa | 1.0 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 0.99 |
| TUBA4A | tubulin, alpha 4a | 0.98 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 0.98 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.97 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.97 |
| RBMXL1 | RNA binding motif protein, X-linked-like 1 | 0.96 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.95 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.95 |
| SPIN2B | spindlin family, member 2B | 0.95 |
| PML | promyelocytic leukemia | 0.95 |
| BAX | BCL2-associated X protein | 0.94 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | 0.94 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.93 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.93 |
| ZNF451 | zinc finger protein 451 | 0.93 |
| GLUL | glutamate-ammonia ligase | 0.93 |
| FOSL2 | FOS-like antigen 2 | 0.92 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.92 |
| TK1 | thymidine kinase 1, soluble | 0.92 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.92 |
| NOTCH3 | notch 3 | 0.91 |
| CIC | capicua transcriptional repressor | 0.91 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.91 |
| TREX1 | three prime repair exonuclease 1 | 0.91 |
| NRBP2 | nuclear receptor binding protein 2 | 0.89 |
| CDCA5 | cell division cycle associated 5 | 0.89 |
| GCH1 | GTP cyclohydrolase 1 | 0.89 |
| TROAP | trophinin associated protein | 0.88 |
| FITM2 | fat storage-inducing transmembrane protein 2 | 0.88 |
| SDC4 | syndecan 4 | 0.88 |
| GGT1 | gamma-glutamyltransferase 1 | 0.88 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | 0.88 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UTP11 | UTP11 small subunit processome component | -3.19 |
| CDCA4 | cell division cycle associated 4 | -3.12 |
| FAM20C | family with sequence similarity 20, member C | -3.0 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -2.92 |
| WDR46 | WD repeat domain 46 | -2.69 |
| FAM207A | family with sequence similarity 207, member A | -2.6 |
| ODC1 | ornithine decarboxylase 1 | -2.5 |
| RSL1D1 | ribosomal L1 domain containing 1 | -2.35 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -2.35 |
| TIGD5 | tigger transposable element derived 5 | -2.33 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -2.32 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -2.29 |
| SURF6 | surfeit 6 | -2.21 |
| RPL7L1 | ribosomal protein L7-like 1 | -2.17 |
| RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | -2.15 |
| NOP53 | NOP53 ribosome biogenesis factor | -2.15 |
| ZC3H3 | zinc finger CCCH-type containing 3 | -2.13 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -2.09 |
| RNF146 | ring finger protein 146 | -1.98 |
| CCDC59 | coiled-coil domain containing 59 | -1.97 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -1.96 |
| UTP6 | UTP6, small subunit (SSU) processome component, homolog (yeast) | -1.9 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -1.84 |
| RPF1 | ribosome production factor 1 homolog (S. cerevisiae) | -1.84 |
| DCAF13 | DDB1 and CUL4 associated factor 13 | -1.83 |
| PDCD11 | programmed cell death 11 | -1.8 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | -1.79 |
| CDK14 | cyclin-dependent kinase 14 | -1.78 |
| ZNF696 | zinc finger protein 696 | -1.75 |
| C6ORF62 | chromosome 6 open reading frame 62 | -1.74 |
| CDC6 | cell division cycle 6 | -1.73 |
| ZNF770 | zinc finger protein 770 | -1.67 |
| RIOK2 | RIO kinase 2 | -1.65 |
| CCDC137 | coiled-coil domain containing 137 | -1.64 |
| ZFHX4 | zinc finger homeobox 4 | -1.62 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -1.58 |
| ING2 | inhibitor of growth family, member 2 | -1.57 |
| KLHL21 | kelch-like family member 21 | -1.56 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | -1.55 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -1.54 |
| SAPCD2 | suppressor APC domain containing 2 | -1.53 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -1.52 |
| NECTIN3 | nectin cell adhesion molecule 3 | -1.51 |
| FCF1 | FCF1 rRNA-processing protein | -1.51 |
| AZIN1 | antizyme inhibitor 1 | -1.49 |
| UTP18 | UTP18 small subunit (SSU) processome component homolog (yeast) | -1.49 |
| RIOK3 | RIO kinase 3 | -1.48 |
| NOL7 | nucleolar protein 7, 27kDa | -1.47 |
| C1ORF131 | chromosome 1 open reading frame 131 | -1.45 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -1.45 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -1.43 |
| CEP57 | centrosomal protein 57kDa | -1.43 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | -1.42 |
| KMT5A | lysine methyltransferase 5A | -1.42 |
| AEN | apoptosis enhancing nuclease | -1.41 |
| DUSP6 | dual specificity phosphatase 6 | -1.41 |
| BYSL | bystin-like | -1.39 |
| RRP7A | ribosomal RNA processing 7 homolog A (S. cerevisiae) | -1.37 |
| EBNA1BP2 | EBNA1 binding protein 2 | -1.36 |
| PUM3 | pumilio RNA binding family member 3 | -1.35 |
| CCDC170 | coiled-coil domain containing 170 | -1.35 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -1.35 |
| AKIRIN2 | akirin 2 | -1.34 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -1.32 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -1.32 |
| VWA1 | von Willebrand factor A domain containing 1 | -1.32 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | -1.31 |
| UTP20 | UTP20, small subunit (SSU) processome component, homolog (yeast) | -1.3 |
| LIAS | lipoic acid synthetase | -1.3 |
| LTV1 | LTV1 ribosome biogenesis factor | -1.3 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -1.3 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -1.29 |
| TCF12 | transcription factor 12 | -1.29 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | -1.29 |
| RPS19BP1 | ribosomal protein S19 binding protein 1 | -1.28 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -1.28 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -1.28 |
| NIFK | nucleolar protein interacting with the FHA domain of MKI67 | -1.28 |
| SIK2 | salt-inducible kinase 2 | -1.28 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -1.27 |
| RBM34 | RNA binding motif protein 34 | -1.26 |
| SYT1 | synaptotagmin I | -1.26 |
| IFRD1 | interferon-related developmental regulator 1 | -1.25 |
| H1-2 | H1.2 linker histone, cluster member | -1.24 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -1.23 |
| E2F2 | E2F transcription factor 2 | -1.22 |
| BRIX1 | BRX1, biogenesis of ribosomes | -1.21 |
| FAM117B | family with sequence similarity 117, member B | -1.19 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -1.19 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -1.19 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | -1.18 |
| EREG | epiregulin | -1.18 |
| NDFIP1 | Nedd4 family interacting protein 1 | -1.18 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -1.18 |
| ZNF385B | zinc finger protein 385B | -1.17 |
| AMD1 | adenosylmethionine decarboxylase 1 | -1.16 |
| EGR1 | early growth response 1 | -1.15 |
| ANAPC16 | anaphase promoting complex subunit 16 | -1.13 |
| ISG20L2 | interferon stimulated exonuclease gene 20kDa-like 2 | -1.13 |
