Brimonidine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.178825
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.1333
LOX lysyl oxidase 0.0937404
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.083758
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0686946
NAV1 neuron navigator 1 0.068502
ZBTB20 zinc finger and BTB domain containing 20 0.0446463
COL8A1 collagen, type VIII, alpha 1 0.0441135
GLIS3 GLIS family zinc finger 3 0.0435098
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0427228
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0412906
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0403901
RSAD2 radical S-adenosyl methionine domain containing 2 0.0394614
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0384376
DOCK5 dedicator of cytokinesis 5 0.0379854
DST dystonin 0.0375883
VMP1 vacuole membrane protein 1 0.036786
VEGFC vascular endothelial growth factor C 0.0363641
COL1A2 collagen, type I, alpha 2 0.0361671
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0360266
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0359908
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0342506
PSD3 pleckstrin and Sec7 domain containing 3 0.033369
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0331304
MEIS2 Meis homeobox 2 0.0328376
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0320173
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.031994
WWTR1 WW domain containing transcription regulator 1 0.0312247
SLC39A11 solute carrier family 39, member 11 0.0308671
EGFR epidermal growth factor receptor 0.0308277
EFNA5 ephrin-A5 0.0307143
COL5A2 collagen, type V, alpha 2 0.0303311
RASAL2 RAS protein activator like 2 0.0297266
MAP1B microtubule-associated protein 1B 0.029104
RIGI RNA sensor RIG-I 0.028975
VCL vinculin 0.0288272
PRELID2 PRELI domain containing 2 0.0284659
EXT1 exostosin glycosyltransferase 1 0.0278471
EHBP1 EH domain binding protein 1 0.0276034
SVIL supervillin 0.0273759
MX2 MX dynamin-like GTPase 2 0.0272203
TENM3 teneurin transmembrane protein 3 0.0271251
FNDC3B fibronectin type III domain containing 3B 0.0268751
CD44 CD44 molecule (Indian blood group) 0.0266807
ERRFI1 ERBB receptor feedback inhibitor 1 0.0266516
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0264027
SMYD3 SET and MYND domain containing 3 0.0262877
HDAC9 histone deacetylase 9 0.0257925
RUNX1 runt-related transcription factor 1 0.0256304
AUTS2 autism susceptibility candidate 2 0.0255924
ASPH aspartate beta-hydroxylase 0.0254353
RABGAP1L RAB GTPase activating protein 1-like 0.0248704
RNF213 ring finger protein 213 0.0246138
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0243988
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.024311
DCLK2 doublecortin-like kinase 2 0.0242261
COL5A1 collagen, type V, alpha 1 0.024114
SDCCAG8 serologically defined colon cancer antigen 8 0.0240653
CDH13 cadherin 13 0.0239378
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0238826
ANKRD36 ankyrin repeat domain 36 0.0236566
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0231992
PLAT plasminogen activator, tissue 0.0231752
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0231501
COPA coatomer protein complex, subunit alpha 0.0229437
MBNL1 muscleblind-like splicing regulator 1 0.0227685
LPP LIM domain containing preferred translocation partner in lipoma 0.0224201
RAD51B RAD51 paralog B 0.0222873
CD59 CD59 molecule, complement regulatory protein 0.0222349
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.021935
MYO9A myosin IXA 0.0217593
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0214026
AOPEP aminopeptidase O (putative) 0.0210737
N4BP2L2 NEDD4 binding protein 2-like 2 0.0207562
LHFPL6 LHFPL tetraspan subfamily member 6 0.0207389
MCL1 myeloid cell leukemia 1 0.020537
CEP112 centrosomal protein 112kDa 0.0204014
RAD50 RAD50 homolog (S. cerevisiae) 0.0202908
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0200905
PARD3 par-3 family cell polarity regulator 0.0199223
PBX3 pre-B-cell leukemia homeobox 3 0.019768
CSNK1A1 casein kinase 1, alpha 1 0.0191067
SAMD9 sterile alpha motif domain containing 9 0.0190211
PDE4D phosphodiesterase 4D, cAMP-specific 0.0190055
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0187442
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0186623
BPTF bromodomain PHD finger transcription factor 0.0186072
TSC22D1 TSC22 domain family, member 1 0.0185708
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0184197
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0180106
NBEAL1 neurobeachin-like 1 0.0178889
FER fer (fps/fes related) tyrosine kinase 0.0178889
TRABD2B TraB domain containing 2B 0.0176899
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0176752
MSN moesin 0.0175948
ARB2A ARB2 cotranscriptional regulator A 0.0175519
SATB2 SATB homeobox 2 0.0174643
SAMD9L sterile alpha motif domain containing 9-like 0.0174345
SMAD3 SMAD family member 3 0.0174322
TRIP12 thyroid hormone receptor interactor 12 0.017329

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.239541
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.17432
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134035
MT2A metallothionein 2A -0.112593
NDRG1 N-myc downstream regulated 1 -0.106727
VIM vimentin -0.105814
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.101374
PTMA prothymosin, alpha -0.0889056
SQSTM1 sequestosome 1 -0.0852933
CSTB cystatin B (stefin B) -0.0815569
S100A10 S100 calcium binding protein A10 -0.0771658
LMNA lamin A/C -0.0756526
FTL ferritin, light polypeptide -0.070598
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0571683
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0546077
TPT1 tumor protein, translationally-controlled 1 -0.0540642
GOLGA4 golgin A4 -0.0534549
ADM adrenomedullin -0.0505274
RPL35A ribosomal protein L35a -0.048341
RPS6 ribosomal protein S6 -0.0454342
THBS2 thrombospondin 2 -0.0438619
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0438508
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0437037
S100A6 S100 calcium binding protein A6 -0.0432384
RPS19 ribosomal protein S19 -0.0408662
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0395876
MXI1 MAX interactor 1, dimerization protein -0.0389671
HSPB1 heat shock 27kDa protein 1 -0.038847
GNAS GNAS complex locus -0.0373898
NAMPT nicotinamide phosphoribosyltransferase -0.0368142
PGK1 phosphoglycerate kinase 1 -0.0366865
RPL28 ribosomal protein L28 -0.0364571
RPS8 ribosomal protein S8 -0.0354515
ACTG1 actin gamma 1 -0.0353957
BHLHE40 basic helix-loop-helix family, member e40 -0.0343818
TPM4 tropomyosin 4 -0.034368
RPS3 ribosomal protein S3 -0.0342957
TMSB4X thymosin beta 4, X-linked -0.0341842
IFITM3 interferon induced transmembrane protein 3 -0.0340037
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0335333
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0333245
HLA-B major histocompatibility complex, class I, B -0.0327451
LDHA lactate dehydrogenase A -0.0325297
INSIG1 insulin induced gene 1 -0.0323386
KDM3A lysine (K)-specific demethylase 3A -0.0318656
CAVIN1 caveolae associated protein 1 -0.0318092
CCND1 cyclin D1 -0.031425
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0311911
KMT2E lysine (K)-specific methyltransferase 2E -0.030727
LGALS1 lectin, galactoside-binding, soluble, 1 -0.030451
RPL32 ribosomal protein L32 -0.0303673
DLG1 discs, large homolog 1 (Drosophila) -0.0301243
GARS1 glycyl-tRNA synthetase 1 -0.0300364
SDK1 sidekick cell adhesion molecule 1 -0.029944
RPL12 ribosomal protein L12 -0.0297597
RPL23 ribosomal protein L23 -0.0296285
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0295582
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0293739
FAM162A family with sequence similarity 162, member A -0.0289851
RPL34 ribosomal protein L34 -0.0288188
LOC112694756 uncharaterized LOC112694756 -0.028267
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0280744
DDIT4 DNA-damage-inducible transcript 4 -0.027606
RPLP2 ribosomal protein, large, P2 -0.0274474
RPL19 ribosomal protein L19 -0.0274413
RPL37A ribosomal protein L37a -0.0268445
SEC61G Sec61 gamma subunit -0.0268336
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0264402
RPLP1 ribosomal protein, large, P1 -0.0263698
HILPDA hypoxia inducible lipid droplet-associated -0.0262188
PKM pyruvate kinase, muscle -0.0261279
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0257206
PFN1 profilin 1 -0.0246972
NAP1L1 nucleosome assembly protein 1-like 1 -0.0244649
RPL36 ribosomal protein L36 -0.0243849
RPL26 ribosomal protein L26 -0.0241143
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0241108
MSI2 musashi RNA-binding protein 2 -0.0233254
WSB1 WD repeat and SOCS box containing 1 -0.0232227
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0230742
EIF1 eukaryotic translation initiation factor 1 -0.0229502
RPS24 ribosomal protein S24 -0.0226859
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0226462
KLF6 Kruppel-like factor 6 -0.0224827
B2M beta-2-microglobulin -0.0222716
RPL11 ribosomal protein L11 -0.0222567
RLF rearranged L-myc fusion -0.0222279
TAGLN2 transgelin 2 -0.0218594
S100A9 S100 calcium binding protein A9 -0.0217605
RACK1 receptor for activated C kinase 1 -0.0213342
FAM107B family with sequence similarity 107, member B -0.0211904
RPS15 ribosomal protein S15 -0.0209613
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.020899
GUK1 guanylate kinase 1 -0.0208807
BSG basigin (Ok blood group) -0.0208149
RPS16 ribosomal protein S16 -0.020647
MBNL2 muscleblind-like splicing regulator 2 -0.0205301
SEPTIN7 septin 7 -0.0204136
RPS13 ribosomal protein S13 -0.0203663
HELZ helicase with zinc finger -0.0203377