| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brimonidine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Brimonidine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.207227 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.156115 |
| NLGN1 | neuroligin 1 | 0.133281 |
| MMP12 | matrix metallopeptidase 12 | 0.114509 |
| YAP1 | Yes-associated protein 1 | 0.100608 |
| HMGA2 | high mobility group AT-hook 2 | 0.094025 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0748949 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0676143 |
| JMJD1C | jumonji domain containing 1C | 0.066894 |
| NHSL1 | NHS-like 1 | 0.0659735 |
| ASPH | aspartate beta-hydroxylase | 0.0568115 |
| EHBP1 | EH domain binding protein 1 | 0.050261 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0501074 |
| NEBL | nebulette | 0.0497105 |
| BCHE | butyrylcholinesterase | 0.049688 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0490397 |
| MTAP | methylthioadenosine phosphorylase | 0.0484759 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0446111 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0439677 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0437582 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0434111 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0432796 |
| RTN4 | reticulon 4 | 0.0422446 |
| PDGFC | platelet derived growth factor C | 0.0417308 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0403392 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0403033 |
| CMIP | c-Maf inducing protein | 0.0396822 |
| EDARADD | EDAR-associated death domain | 0.0385211 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0380042 |
| VCL | vinculin | 0.0369786 |
| NABP1 | nucleic acid binding protein 1 | 0.0360418 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0353456 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0342993 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0332329 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0329979 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0329953 |
| EGR1 | early growth response 1 | 0.0328566 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0320335 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.031219 |
| RCOR1 | REST corepressor 1 | 0.0310067 |
| RASAL2 | RAS protein activator like 2 | 0.0306944 |
| RAB10 | RAB10, member RAS oncogene family | 0.0304326 |
| TMEM41B | transmembrane protein 41B | 0.0299976 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0297532 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0295557 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0294596 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0290817 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0290621 |
| PCDH7 | protocadherin 7 | 0.0286022 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0283227 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0268068 |
| NRXN3 | neurexin 3 | 0.026738 |
| ERBIN | erbb2 interacting protein | 0.0266526 |
| INTS6 | integrator complex subunit 6 | 0.0264103 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0260829 |
| HDAC9 | histone deacetylase 9 | 0.0257311 |
| DTNA | dystrobrevin, alpha | 0.0257173 |
| EGFR | epidermal growth factor receptor | 0.0255158 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0251545 |
| MYPN | myopalladin | 0.0250628 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0249913 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0245767 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0235679 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0232186 |
| TENM3 | teneurin transmembrane protein 3 | 0.0231797 |
| RHOA | ras homolog family member A | 0.0230341 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0229404 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0223576 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.022211 |
| RNF13 | ring finger protein 13 | 0.021993 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0217988 |
| SETD5 | SET domain containing 5 | 0.0216859 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0215671 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0214349 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.02115 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0209858 |
| EXOC6B | exocyst complex component 6B | 0.0208872 |
| BPTF | bromodomain PHD finger transcription factor | 0.0208362 |
| CUX1 | cut-like homeobox 1 | 0.0207598 |
| ZNF804A | zinc finger protein 804A | 0.0205367 |
| PRKCE | protein kinase C, epsilon | 0.0203752 |
| TPM3 | tropomyosin 3 | 0.0203726 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0199395 |
| NAV3 | neuron navigator 3 | 0.0194358 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0193913 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0193043 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0192206 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0191573 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0190406 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0190061 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0189999 |
| R3HDM2 | R3H domain containing 2 | 0.018946 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0188739 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0188407 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0188114 |
| FHIT | fragile histidine triad | 0.0187753 |
| MCL1 | myeloid cell leukemia 1 | 0.0187474 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0187282 |
| NEGR1 | neuronal growth regulator 1 | 0.0186033 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0185322 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.121311 |
| VIM | vimentin | -0.0989624 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0939193 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0733899 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0721758 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0669302 |
| FTL | ferritin, light polypeptide | -0.0648066 |
| RPLP1 | ribosomal protein, large, P1 | -0.0647137 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0599361 |
| PTMA | prothymosin, alpha | -0.0584277 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0547714 |
| RPS19 | ribosomal protein S19 | -0.0513244 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0510241 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0488619 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0481825 |
| RPL19 | ribosomal protein L19 | -0.0479597 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0479487 |
| YBX1 | Y box binding protein 1 | -0.047129 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.046576 |
| RPL8 | ribosomal protein L8 | -0.0463362 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0453049 |
| YBX3 | Y box binding protein 3 | -0.0429621 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0423441 |
| RPS3 | ribosomal protein S3 | -0.0412943 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0405564 |
| RACK1 | receptor for activated C kinase 1 | -0.040313 |
| H1-0 | H1.0 linker histone | -0.0396898 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0395496 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0394994 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0393596 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0387562 |
| CCND1 | cyclin D1 | -0.0386316 |
| CLDN1 | claudin 1 | -0.0384839 |
| RPL36 | ribosomal protein L36 | -0.0381333 |
| TMEM123 | transmembrane protein 123 | -0.037877 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0377975 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0377461 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0375841 |
| RLF | rearranged L-myc fusion | -0.0372757 |
| KIF5B | kinesin family member 5B | -0.0360925 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0358756 |
| SLC38A1 | solute carrier family 38, member 1 | -0.035655 |
| RPL12 | ribosomal protein L12 | -0.0345089 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0342743 |
| RPS8 | ribosomal protein S8 | -0.0338683 |
| MATR3 | matrin 3 | -0.0338673 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0331095 |
| HMGB1 | high mobility group box 1 | -0.0330326 |
| HDLBP | high density lipoprotein binding protein | -0.0330213 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0321721 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0320603 |
| EDN1 | endothelin 1 | -0.0316915 |
| RPL32 | ribosomal protein L32 | -0.0308168 |
| RBM39 | RNA binding motif protein 39 | -0.0307248 |
| FUS | FUS RNA binding protein | -0.030527 |
| RPS6 | ribosomal protein S6 | -0.0303326 |
| NPR2 | natriuretic peptide receptor 2 | -0.0294464 |
| HMGB2 | high mobility group box 2 | -0.0294334 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.029239 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0286564 |
| RPS24 | ribosomal protein S24 | -0.0285802 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0285737 |
| RPL34 | ribosomal protein L34 | -0.0285117 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.028377 |
| PTMS | parathymosin | -0.0278479 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.027837 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0277209 |
| RPL23 | ribosomal protein L23 | -0.0276962 |
| RPS4X | ribosomal protein S4, X-linked | -0.0275827 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0275415 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0274603 |
| PFN1 | profilin 1 | -0.0272005 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0269368 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0263435 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0262457 |
| PRRC2C | proline-rich coiled-coil 2C | -0.02614 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0257831 |
| RPLP0 | ribosomal protein, large, P0 | -0.0257235 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.025694 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0255016 |
| XPO1 | exportin 1 | -0.025385 |
| TPR | translocated promoter region, nuclear basket protein | -0.0252617 |
| RPL26 | ribosomal protein L26 | -0.0250437 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0248683 |
| KLF6 | Kruppel-like factor 6 | -0.0246731 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0245646 |
| RPL38 | ribosomal protein L38 | -0.0241724 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0241007 |
| RPS16 | ribosomal protein S16 | -0.0236955 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0236816 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0236399 |
| SEPTIN7 | septin 7 | -0.0234758 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0233067 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0231014 |
| GNAS | GNAS complex locus | -0.0230845 |
| SPAG9 | sperm associated antigen 9 | -0.0230462 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0227149 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0223991 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | -0.0223679 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0223649 |
