Brimonidine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.14542
PTPRD protein tyrosine phosphatase, receptor type, D 0.116845
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.114373
MEIS2 Meis homeobox 2 0.0796564
SYT1 synaptotagmin I 0.0747426
ITPRID2 ITPR interacting domain containing 2 0.0551281
TPST1 tyrosylprotein sulfotransferase 1 0.0518301
DST dystonin 0.0502675
PSD3 pleckstrin and Sec7 domain containing 3 0.0478641
PLPP1 phospholipid phosphatase 1 0.0478558
SOS1 son of sevenless homolog 1 (Drosophila) 0.0468046
NCAM2 neural cell adhesion molecule 2 0.043556
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0427979
PTEN phosphatase and tensin homolog 0.042752
SIK2 salt-inducible kinase 2 0.039666
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0387553
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0383259
KLHL13 kelch-like family member 13 0.0379623
AKAP12 A kinase (PRKA) anchor protein 12 0.0373216
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0369656
TENT5A terminal nucleotidyltransferase 5A 0.0361035
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0353805
TLE4 transducin-like enhancer of split 4 0.0351872
ZBTB20 zinc finger and BTB domain containing 20 0.0347194
ADGRB3 adhesion G protein-coupled receptor B3 0.034699
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0335529
TRIO trio Rho guanine nucleotide exchange factor 0.0318783
HAS2 hyaluronan synthase 2 0.0318551
PHF3 PHD finger protein 3 0.0317181
LINGO2 leucine rich repeat and Ig domain containing 2 0.0310328
RALYL RALY RNA binding protein-like 0.0304643
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0303821
PCDH7 protocadherin 7 0.0302159
ADGRG6 adhesion G protein-coupled receptor G6 0.0298938
PTPRK protein tyrosine phosphatase, receptor type, K 0.0297847
GLCCI1 glucocorticoid induced 1 0.0294949
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0284837
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0281698
RUNX1 runt-related transcription factor 1 0.0281003
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0280719
IFI16 interferon, gamma-inducible protein 16 0.0280186
ZFC3H1 zinc finger, C3H1-type containing 0.027994
FMN1 formin 1 0.0278186
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0265976
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0262122
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.025925
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0257254
NRP1 neuropilin 1 0.02487
CDC27 cell division cycle 27 0.0247258
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0238943
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0238207
STC1 stanniocalcin 1 0.0237488
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0230402
ARHGAP9 Rho GTPase activating protein 9 0.0230006
PLAT plasminogen activator, tissue 0.0228791
DISP1 dispatched homolog 1 (Drosophila) 0.022426
ZNF292 zinc finger protein 292 0.0223567
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0222659
LIMS1 LIM and senescent cell antigen-like domains 1 0.0221162
ADAR adenosine deaminase, RNA-specific 0.0220181
HAND2 heart and neural crest derivatives expressed 2 0.0214568
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.021185
PANK3 pantothenate kinase 3 0.021162
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0208537
PEAK1 pseudopodium-enriched atypical kinase 1 0.0208389
NRIP1 nuclear receptor interacting protein 1 0.0207521
DIAPH2 diaphanous-related formin 2 0.0207016
ETNK1 ethanolamine kinase 1 0.0203005
PCDH15 protocadherin-related 15 0.0202472
ADGRL2 adhesion G protein-coupled receptor L2 0.0199872
RAB30 RAB30, member RAS oncogene family 0.0199707
SLITRK6 SLIT and NTRK-like family, member 6 0.0199693
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0194562
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0194557
PCBP3 poly(rC) binding protein 3 0.0193424
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0192745
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0192196
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0191744
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0191477
GIGYF2 GRB10 interacting GYF protein 2 0.0190992
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0189852
AHCTF1 AT hook containing transcription factor 1 0.0188625
BPTF bromodomain PHD finger transcription factor 0.0188053
PUM2 pumilio RNA-binding family member 2 0.0187497
KIAA1217 KIAA1217 0.018713
PELI1 pellino E3 ubiquitin protein ligase 1 0.018639
ANKRD17 ankyrin repeat domain 17 0.0186246
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0186238
NKTR natural killer cell triggering receptor 0.0185243
MICU1 mitochondrial calcium uptake 1 0.0184785
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0182801
MTREX Mtr4 exosome RNA helicase 0.018265
AEBP2 AE binding protein 2 0.0181783
RTN4 reticulon 4 0.0179902
NPEPPS aminopeptidase puromycin sensitive 0.0179649
SECISBP2L SECIS binding protein 2-like 0.0179311
RAD51B RAD51 paralog B 0.0176888
OCIAD1 OCIA domain containing 1 0.0174507
FER fer (fps/fes related) tyrosine kinase 0.0174054
PACS1 phosphofurin acidic cluster sorting protein 1 0.0174044

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.136314
NALF1 NALCN channel auxiliary factor 1 -0.100691
VCL vinculin -0.0989982
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0981109
NRG1 neuregulin 1 -0.0863164
VIM vimentin -0.0685153
EXT1 exostosin glycosyltransferase 1 -0.0662005
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0644339
FTL ferritin, light polypeptide -0.0542178
RPL35A ribosomal protein L35a -0.0513171
RPL23 ribosomal protein L23 -0.0508914
RPL38 ribosomal protein L38 -0.0491682
ACTG1 actin gamma 1 -0.0468445
RPL19 ribosomal protein L19 -0.0457754
RPL37A ribosomal protein L37a -0.0451158
RPL34 ribosomal protein L34 -0.0427796
RPS6 ribosomal protein S6 -0.0418655
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0417359
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0416814
TMSB10 thymosin beta 10 -0.0391663
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0378882
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0370698
NDRG1 N-myc downstream regulated 1 -0.0366008
TPM1 tropomyosin 1 (alpha) -0.0362634
KPNB1 karyopherin (importin) beta 1 -0.0360696
RPLP1 ribosomal protein, large, P1 -0.0352041
LSAMP limbic system-associated membrane protein -0.0350837
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0339689
WSB1 WD repeat and SOCS box containing 1 -0.0336519
TPT1 tumor protein, translationally-controlled 1 -0.0333368
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0329243
RPL32 ribosomal protein L32 -0.0328192
CEMIP cell migration inducing protein, hyaluronan binding -0.0323297
LMNA lamin A/C -0.0323121
CCND1 cyclin D1 -0.0322815
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.031824
HELZ helicase with zinc finger -0.0316589
DTNA dystrobrevin, alpha -0.031142
RPS24 ribosomal protein S24 -0.030888
RPL28 ribosomal protein L28 -0.030695
EGFR epidermal growth factor receptor -0.0303378
RPS19 ribosomal protein S19 -0.0302734
RPS3 ribosomal protein S3 -0.0300847
FAM13A family with sequence similarity 13, member A -0.029471
THSD4 thrombospondin, type I, domain containing 4 -0.0294194
CUX1 cut-like homeobox 1 -0.0292384
PDLIM5 PDZ and LIM domain 5 -0.0280234
DDIT4 DNA-damage-inducible transcript 4 -0.0279978
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0276528
NPAS2 neuronal PAS domain protein 2 -0.027574
LPIN1 lipin 1 -0.0274739
ANXA2 annexin A2 -0.0273407
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0267794
ZFAND3 zinc finger, AN1-type domain 3 -0.0267133
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0266325
HDLBP high density lipoprotein binding protein -0.0262912
RPS21 ribosomal protein S21 -0.0262533
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.026103
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0254806
RSRC2 arginine/serine-rich coiled-coil 2 -0.0251709
MAML2 mastermind-like 2 (Drosophila) -0.0251373
KDM3A lysine (K)-specific demethylase 3A -0.024994
CDH13 cadherin 13 -0.024854
RPL26 ribosomal protein L26 -0.0247985
ACBD3 acyl-CoA binding domain containing 3 -0.0247694
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0245035
TPM4 tropomyosin 4 -0.0238236
QKI QKI, KH domain containing, RNA binding -0.0235127
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0234015
KLHL5 kelch-like family member 5 -0.0231042
SLMAP sarcolemma associated protein -0.0230862
NAP1L1 nucleosome assembly protein 1-like 1 -0.023052
SQSTM1 sequestosome 1 -0.0228248
EIF5B eukaryotic translation initiation factor 5B -0.0227334
EFNA5 ephrin-A5 -0.0226693
CRABP2 cellular retinoic acid binding protein 2 -0.0226684
RPS8 ribosomal protein S8 -0.0226318
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0225534
MORF4L1 mortality factor 4 like 1 -0.0225532
PKM pyruvate kinase, muscle -0.022456
HILPDA hypoxia inducible lipid droplet-associated -0.0221897
NPAS3 neuronal PAS domain protein 3 -0.0220553
POTEF POTE ankyrin domain family, member F -0.0220153
INTS6 integrator complex subunit 6 -0.0219184
SEPTIN9 septin 9 -0.0218796
GARS1 glycyl-tRNA synthetase 1 -0.0217026
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0214014
EGR1 early growth response 1 -0.0213696
IER3 immediate early response 3 -0.0213218
RPL36 ribosomal protein L36 -0.021234
SEC31A SEC31 homolog A (S. cerevisiae) -0.0211266
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0211245
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.02071
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0205821
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0205
NES nestin -0.0203432
RPS23 ribosomal protein S23 -0.0201791
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0200064
HIP1 huntingtin interacting protein 1 -0.0199344
NCOR1 nuclear receptor corepressor 1 -0.0197108