Brimonidine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0746889
VCL vinculin 0.0617016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0580031
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0535299
LMO7 LIM domain 7 0.0526623
PTBP3 polypyrimidine tract binding protein 3 0.0524358
MACC1 metastasis associated in colon cancer 1 0.0486028
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0485273
STK24 serine/threonine kinase 24 0.0476187
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0473174
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0472655
SMAD3 SMAD family member 3 0.0444219
VMP1 vacuole membrane protein 1 0.0425876
YAP1 Yes-associated protein 1 0.0405884
RNF43 ring finger protein 43 0.0394716
MYO1E myosin IE 0.0365629
NRIP1 nuclear receptor interacting protein 1 0.0352385
IL20RA interleukin 20 receptor, alpha 0.0325745
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0324315
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0321709
PDZD8 PDZ domain containing 8 0.0318778
DSCAM Down syndrome cell adhesion molecule 0.031858
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0309856
SERINC5 serine incorporator 5 0.030887
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0308238
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0305387
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0300954
AREG amphiregulin 0.0297409
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0294296
FHL2 four and a half LIM domains 2 0.0293707
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.029219
AKAP13 A kinase (PRKA) anchor protein 13 0.029004
ACTN4 actinin, alpha 4 0.0277288
EPHB2 EPH receptor B2 0.0272736
RUNX1 runt-related transcription factor 1 0.0270308
STS steroid sulfatase (microsomal), isozyme S 0.0268624
SHB Src homology 2 domain containing adaptor protein B 0.0268511
BCL2L1 BCL2-like 1 0.0264142
SH3RF1 SH3 domain containing ring finger 1 0.0250779
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0247962
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0235803
ETV6 ets variant 6 0.0232117
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0230942
EREG epiregulin 0.0226387
OCLN occludin 0.0221991
TMEM51 transmembrane protein 51 0.0218801
PELI1 pellino E3 ubiquitin protein ligase 1 0.0208139
DPP4 dipeptidyl-peptidase 4 0.0205621
DUSP10 dual specificity phosphatase 10 0.0205277
NCOA2 nuclear receptor coactivator 2 0.0201056
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0199245
TC2N tandem C2 domains, nuclear 0.0199097
SPRED1 sprouty-related, EVH1 domain containing 1 0.0197867
IFNGR1 interferon gamma receptor 1 0.0197242
MLPH melanophilin 0.01969
PLAUR plasminogen activator, urokinase receptor 0.019595
PHACTR4 phosphatase and actin regulator 4 0.0195618
FOXO3 forkhead box O3 0.0194813
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0194161
ERRFI1 ERBB receptor feedback inhibitor 1 0.0193073
CTNND1 catenin (cadherin-associated protein), delta 1 0.0191175
TJP1 tight junction protein 1 0.0190494
DIAPH1 diaphanous-related formin 1 0.018679
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0185633
UBAP1 ubiquitin associated protein 1 0.0185042
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0184828
MEIS2 Meis homeobox 2 0.018433
VEGFA vascular endothelial growth factor A 0.0182476
PLSCR2 phospholipid scramblase 2 0.0180963
EFNB2 ephrin-B2 0.0179431
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0176843
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0175719
ANXA11 annexin A11 0.0174312
NDFIP2 Nedd4 family interacting protein 2 0.017397
ZBTB43 zinc finger and BTB domain containing 43 0.0172722
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.01688
CCNL1 cyclin L1 0.01686
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0166689
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0164205
WWOX WW domain containing oxidoreductase 0.0164116
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0163287
KIAA1217 KIAA1217 0.0162755
MCTP1 multiple C2 domains, transmembrane 1 0.016002
CEMIP2 cell migration inducing hyaluronidase 2 0.0157946
TTC39B tetratricopeptide repeat domain 39B 0.0156213
TRERF1 transcriptional regulating factor 1 0.0154799
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0153216
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0152521
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0152055
SPRED2 sprouty-related, EVH1 domain containing 2 0.0151716
SUSD1 sushi domain containing 1 0.0148736
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0148727
SMAD5 SMAD family member 5 0.0148466
CD46 CD46 molecule, complement regulatory protein 0.0148291
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0147363
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0147157
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0147061
NCOR2 nuclear receptor corepressor 2 0.0146306
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0144466
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0144378

decreased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 -0.175811
TPT1 tumor protein, translationally-controlled 1 -0.171785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.166291
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.153345
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.137542
EPSTI1 epithelial stromal interaction 1 (breast) -0.105744
PTMA prothymosin, alpha -0.102221
B2M beta-2-microglobulin -0.0930701
GMDS GDP-mannose 4,6-dehydratase -0.0930483
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0897881
GOLGB1 golgin B1 -0.0859268
RRBP1 ribosome binding protein 1 -0.0842607
GCLC glutamate-cysteine ligase, catalytic subunit -0.0825088
LYZ lysozyme -0.0773524
ZMYND8 zinc finger, MYND-type containing 8 -0.0767483
FNDC3A fibronectin type III domain containing 3A -0.075887
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0757882
HLA-B major histocompatibility complex, class I, B -0.0731446
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.072296
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0674572
PDIA3 protein disulfide isomerase family A, member 3 -0.065767
AHI1 Abelson helper integration site 1 -0.0652854
SP100 SP100 nuclear antigen -0.0645055
RNF213 ring finger protein 213 -0.0643763
NPSR1 neuropeptide S receptor 1 -0.0631954
RIGI RNA sensor RIG-I -0.0627208
CANX calnexin -0.062541
BTBD9 BTB (POZ) domain containing 9 -0.0624418
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0597226
FTL ferritin, light polypeptide -0.0590954
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0553603
IFI27 interferon, alpha-inducible protein 27 -0.0527439
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0525971
ANKHD1 ankyrin repeat and KH domain containing 1 -0.052579
ENO1 enolase 1, (alpha) -0.0520457
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0517656
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0507705
FNDC3B fibronectin type III domain containing 3B -0.0503119
MX2 MX dynamin-like GTPase 2 -0.0495088
MORF4L2 mortality factor 4 like 2 -0.0484848
PHF3 PHD finger protein 3 -0.0480763
MUC20 mucin 20, cell surface associated -0.0478122
AGR2 anterior gradient 2 -0.047101
ARHGAP26 Rho GTPase activating protein 26 -0.0469595
PATJ PATJ crumbs cell polarity complex component -0.0467016
HDLBP high density lipoprotein binding protein -0.0463416
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0454111
RPL34 ribosomal protein L34 -0.0449515
LMAN1 lectin, mannose-binding, 1 -0.0448106
SEC24D SEC24 family member D -0.0447665
XAF1 XIAP associated factor 1 -0.0445795
TTC3 tetratricopeptide repeat domain 3 -0.0444271
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0442725
RPS6 ribosomal protein S6 -0.04302
CALR calreticulin -0.0429655
HLA-E major histocompatibility complex, class I, E -0.0429437
UBC ubiquitin C -0.0423269
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0422117
HM13 histocompatibility (minor) 13 -0.0410685
H1-0 H1.0 linker histone -0.0403356
SQSTM1 sequestosome 1 -0.0400089
RAB7A RAB7A, member RAS oncogene family -0.0392869
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0392809
MT2A metallothionein 2A -0.0392062
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0390072
RPL35A ribosomal protein L35a -0.0387688
PKM pyruvate kinase, muscle -0.0385244
SEC31A SEC31 homolog A (S. cerevisiae) -0.0383128
CSTB cystatin B (stefin B) -0.0378512
EIF1 eukaryotic translation initiation factor 1 -0.0370602
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0366952
TMSB10 thymosin beta 10 -0.0362687
RPL19 ribosomal protein L19 -0.0360779
WDR45B WD repeat domain 45B -0.0359774
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0358123
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0356282
MPHOSPH8 M-phase phosphoprotein 8 -0.0355064
PDIA4 protein disulfide isomerase family A, member 4 -0.0354512
IRF1 interferon regulatory factor 1 -0.0349493
MON2 MON2 homolog (S. cerevisiae) -0.0349391
NDRG1 N-myc downstream regulated 1 -0.0348662
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0347847
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0344717
EGR1 early growth response 1 -0.0343133
PDIA6 protein disulfide isomerase family A, member 6 -0.0339553
GOLGA4 golgin A4 -0.0331909
TSHZ2 teashirt zinc finger homeobox 2 -0.0331341
GOLGA3 golgin A3 -0.0327354
LOC102724023 ES1 protein homolog, mitochondrial -0.0324191
PGK1 phosphoglycerate kinase 1 -0.0313774
RAB6A RAB6A, member RAS oncogene family -0.0313441
VDAC1 voltage-dependent anion channel 1 -0.0312253
RPL11 ribosomal protein L11 -0.0311812
RAB1A RAB1A, member RAS oncogene family -0.0311769
PERP PERP, TP53 apoptosis effector -0.0311101
PRRC2C proline-rich coiled-coil 2C -0.0309898
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -0.0309552
GNAS GNAS complex locus -0.0309239
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0308854
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0308206