| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brimonidine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Brimonidine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.27326 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0708599 |
| ATP13A3 | ATPase type 13A3 | 0.0657519 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0653756 |
| STC1 | stanniocalcin 1 | 0.0548066 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0439051 |
| HMGA2 | high mobility group AT-hook 2 | 0.0384107 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0383629 |
| OSMR | oncostatin M receptor | 0.0359908 |
| CD44 | CD44 molecule (Indian blood group) | 0.0358524 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0344455 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0328859 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0317685 |
| HAS2 | hyaluronan synthase 2 | 0.0310513 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0301361 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0291545 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0272276 |
| NRP1 | neuropilin 1 | 0.0266945 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0262867 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0255219 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0255102 |
| ARRDC3 | arrestin domain containing 3 | 0.0248925 |
| TMEM165 | transmembrane protein 165 | 0.0247184 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0245669 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0243408 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0241149 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0238126 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0232691 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0229102 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0228415 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.022761 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0220041 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0216596 |
| TMF1 | TATA element modulatory factor 1 | 0.0216502 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0215557 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0208577 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0200763 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0199421 |
| EFNA5 | ephrin-A5 | 0.0197302 |
| LOXL2 | lysyl oxidase-like 2 | 0.0196152 |
| EVI5 | ecotropic viral integration site 5 | 0.0195629 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0195297 |
| POSTN | periostin, osteoblast specific factor | 0.0194808 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0192648 |
| SYNJ2 | synaptojanin 2 | 0.0190448 |
| JAK2 | Janus kinase 2 | 0.0185475 |
| FN1 | fibronectin 1 | 0.0182014 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0179815 |
| DUSP6 | dual specificity phosphatase 6 | 0.0179643 |
| SMAD3 | SMAD family member 3 | 0.0178616 |
| CLMP | CXADR-like membrane protein | 0.0177908 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0176404 |
| LDHA | lactate dehydrogenase A | 0.0171385 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0170731 |
| RASA2 | RAS p21 protein activator 2 | 0.0168092 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0166162 |
| VEGFC | vascular endothelial growth factor C | 0.0165616 |
| CDC27 | cell division cycle 27 | 0.0161387 |
| MX2 | MX dynamin-like GTPase 2 | 0.0160285 |
| KAZN | kazrin, periplakin interacting protein | 0.0159038 |
| PTK2 | protein tyrosine kinase 2 | 0.0158336 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0158195 |
| TXNRD1 | thioredoxin reductase 1 | 0.0157686 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.015539 |
| ECE1 | endothelin converting enzyme 1 | 0.0153966 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0153833 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0153426 |
| JMJD1C | jumonji domain containing 1C | 0.0152864 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0152417 |
| PLSCR1 | phospholipid scramblase 1 | 0.015009 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0149983 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.014664 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0146535 |
| IL6 | interleukin 6 | 0.0146482 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0145161 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0144362 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.014263 |
| SVIL | supervillin | 0.0141653 |
| EGR1 | early growth response 1 | 0.0139345 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0137832 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0137603 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0136412 |
| VMP1 | vacuole membrane protein 1 | 0.0136242 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0136125 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0135608 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0135557 |
| NKTR | natural killer cell triggering receptor | 0.0134301 |
| PRRX1 | paired related homeobox 1 | 0.0133727 |
| FAM107B | family with sequence similarity 107, member B | 0.0132658 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0132171 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0132064 |
| CDK19 | cyclin-dependent kinase 19 | 0.0130609 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0125307 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0125144 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.012506 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0122355 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0122146 |
| SOCS5 | suppressor of cytokine signaling 5 | 0.0121352 |
| TAOK3 | TAO kinase 3 | 0.0119584 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0118149 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.24924 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.155614 |
| COL1A1 | collagen, type I, alpha 1 | -0.14669 |
| CDH13 | cadherin 13 | -0.144388 |
| COL6A3 | collagen, type VI, alpha 3 | -0.134291 |
| NDRG1 | N-myc downstream regulated 1 | -0.133303 |
| CADM1 | cell adhesion molecule 1 | -0.125592 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114326 |
| COL5A1 | collagen, type V, alpha 1 | -0.106034 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0965255 |
| TMSB10 | thymosin beta 10 | -0.0945378 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0926978 |
| IER3 | immediate early response 3 | -0.0889054 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0870874 |
| FBN1 | fibrillin 1 | -0.0762199 |
| ENO1 | enolase 1, (alpha) | -0.0740127 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0678578 |
| MT2A | metallothionein 2A | -0.0663141 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0624993 |
| VIM | vimentin | -0.062443 |
| FTL | ferritin, light polypeptide | -0.0619334 |
| RPS8 | ribosomal protein S8 | -0.061676 |
| AHNAK | AHNAK nucleoprotein | -0.0585443 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0556083 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0543584 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0539851 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0521846 |
| UBC | ubiquitin C | -0.0519479 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0510463 |
| SQSTM1 | sequestosome 1 | -0.0508277 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0492809 |
| RPL35A | ribosomal protein L35a | -0.049263 |
| ACTG1 | actin gamma 1 | -0.0490717 |
| RPS6 | ribosomal protein S6 | -0.0484325 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0473469 |
| COL1A2 | collagen, type I, alpha 2 | -0.0469169 |
| CALD1 | caldesmon 1 | -0.0460984 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0450051 |
| PTMA | prothymosin, alpha | -0.0447893 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0439228 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0428636 |
| CANX | calnexin | -0.0419416 |
| MTDH | metadherin | -0.0412132 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0409841 |
| CALR | calreticulin | -0.0407352 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0406476 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.038665 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0384037 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0374386 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0370191 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0369944 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0352948 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0348898 |
| DST | dystonin | -0.0340577 |
| QKI | QKI, KH domain containing, RNA binding | -0.034024 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0338129 |
| ADM | adrenomedullin | -0.0335445 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0335299 |
| RPL8 | ribosomal protein L8 | -0.032684 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0324864 |
| RPL23 | ribosomal protein L23 | -0.0323417 |
| STC2 | stanniocalcin 2 | -0.0321831 |
| HDAC9 | histone deacetylase 9 | -0.0320124 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0316727 |
| RPS27A | ribosomal protein S27a | -0.0309203 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0309056 |
| CALU | calumenin | -0.0307174 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0305063 |
| APP | amyloid beta (A4) precursor protein | -0.0301407 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0298771 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0297701 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.029618 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0291393 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0286142 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0285625 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.028308 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.028294 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0282052 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0281109 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0278151 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0276127 |
| FLNA | filamin A, alpha | -0.0275326 |
| RPL36 | ribosomal protein L36 | -0.0272229 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0270039 |
| RPL19 | ribosomal protein L19 | -0.0267147 |
| TMSB4X | thymosin beta 4, X-linked | -0.0266896 |
| S100A9 | S100 calcium binding protein A9 | -0.026596 |
| HDLBP | high density lipoprotein binding protein | -0.0265102 |
| EGFR | epidermal growth factor receptor | -0.0264858 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0264848 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0258714 |
| PLEC | plectin | -0.0258268 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0258176 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0256897 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0251604 |
| RPL32 | ribosomal protein L32 | -0.0249228 |
| DGKI | diacylglycerol kinase, iota | -0.0248081 |
| JAK1 | Janus kinase 1 | -0.0247156 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0246555 |
| RPL5 | ribosomal protein L5 | -0.0246435 |
