Brimonidine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.183201
FN1 fibronectin 1 0.171256
C3 complement component 3 0.143397
APOB apolipoprotein B 0.142469
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.129064
ITGAV integrin, alpha V 0.116931
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.114751
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.113634
VCL vinculin 0.102113
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0991088
NKD1 naked cuticle homolog 1 (Drosophila) 0.0971981
DLC1 DLC1 Rho GTPase activating protein 0.0940717
SLC38A2 solute carrier family 38, member 2 0.0864034
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0848094
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0786709
PAWR PRKC, apoptosis, WT1, regulator 0.0776167
BCL2L1 BCL2-like 1 0.0753812
ARHGAP9 Rho GTPase activating protein 9 0.0730387
EHBP1 EH domain binding protein 1 0.0712945
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0674561
FRMD5 FERM domain containing 5 0.0670983
SVIL supervillin 0.0653889
MRTFA myocardin related transcription factor A 0.0643938
FOXP1 forkhead box P1 0.063857
ABTB3 ankyrin repeat and BTB domain containing 3 0.0634238
ELL2 elongation factor, RNA polymerase II, 2 0.0606845
JMJD1C jumonji domain containing 1C 0.0599667
RTN4 reticulon 4 0.0587467
DSPP dentin sialophosphoprotein 0.0569699
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0539666
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.0535464
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0530122
MT2A metallothionein 2A 0.05227
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.051894
ZNF644 zinc finger protein 644 0.0518061
DST dystonin 0.0509916
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0500241
ZFAND3 zinc finger, AN1-type domain 3 0.0500046
FNDC3B fibronectin type III domain containing 3B 0.0497796
NRIP1 nuclear receptor interacting protein 1 0.0492209
PTBP3 polypyrimidine tract binding protein 3 0.0489307
GPC3 glypican 3 0.0487982
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0486798
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0482852
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0476929
FAT1 FAT atypical cadherin 1 0.0476329
ITCH itchy E3 ubiquitin protein ligase 0.0468696
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0460291
ITGB5 integrin, beta 5 0.0457233
LCOR ligand dependent nuclear receptor corepressor 0.0451129
AKAP12 A kinase (PRKA) anchor protein 12 0.0450234
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0446787
AFDN afadin, adherens junction formation factor 0.0436628
ANO6 anoctamin 6 0.0436624
ANKRD11 ankyrin repeat domain 11 0.0434469
CFB complement factor B 0.042718
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0425125
TRIM26 tripartite motif containing 26 0.0424809
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0422739
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0417614
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0404403
RUNX1 runt-related transcription factor 1 0.0401217
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0395345
FOXO1 forkhead box O1 0.0394118
ENAH enabled homolog (Drosophila) 0.0392162
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0387938
VMP1 vacuole membrane protein 1 0.0385571
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0375037
DOCK4 dedicator of cytokinesis 4 0.0374485
DNAH17 dynein, axonemal, heavy chain 17 0.0371285
MALT1 MALT1 paracaspase 0.0370579
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0369939
A2M alpha-2-macroglobulin 0.036503
GPC6 glypican 6 0.0360678
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0360393
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0358046
TM9SF3 transmembrane 9 superfamily member 3 0.0356917
EML4 echinoderm microtubule associated protein like 4 0.0354201
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0343414
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0342269
TMEM123 transmembrane protein 123 0.0328528
TCF12 transcription factor 12 0.0328428
MYH9 myosin, heavy chain 9, non-muscle 0.0327281
MBNL3 muscleblind-like splicing regulator 3 0.0321634
SAMD4A sterile alpha motif domain containing 4A 0.0320451
TXNRD1 thioredoxin reductase 1 0.0319363
CEMIP2 cell migration inducing hyaluronidase 2 0.0316915
UBASH3B ubiquitin associated and SH3 domain containing B 0.0312506
CNKSR3 CNKSR family member 3 0.0309057
MAML2 mastermind-like 2 (Drosophila) 0.0307864
ERRFI1 ERBB receptor feedback inhibitor 1 0.0307588
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0305634
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0300003
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0299088
TRIP12 thyroid hormone receptor interactor 12 0.0298744
FERMT1 fermitin family member 1 0.0297273
LMCD1 LIM and cysteine-rich domains 1 0.0297018
IGF2 insulin-like growth factor 2 0.0296158
ANXA5 annexin A5 0.0295939
FAM135A family with sequence similarity 135, member A 0.0295906

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0712377
DTNA dystrobrevin, alpha -0.0582385
INTS6 integrator complex subunit 6 -0.0576966
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0525818
NDRG1 N-myc downstream regulated 1 -0.0476875
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0462367
RPL23 ribosomal protein L23 -0.0452619
RPL11 ribosomal protein L11 -0.0437833
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0396855
RPL35A ribosomal protein L35a -0.037046
DDIT4 DNA-damage-inducible transcript 4 -0.036716
TPT1 tumor protein, translationally-controlled 1 -0.0362161
APOA1 apolipoprotein A-I -0.035398
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0345444
FTL ferritin, light polypeptide -0.034412
CP ceruloplasmin (ferroxidase) -0.0321485
RACK1 receptor for activated C kinase 1 -0.0321385
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.031712
RPS19 ribosomal protein S19 -0.0307567
NAMPT nicotinamide phosphoribosyltransferase -0.0306073
KMT2E lysine (K)-specific methyltransferase 2E -0.0292985
SDC4 syndecan 4 -0.0291785
RPL12 ribosomal protein L12 -0.0289252
ATF3 activating transcription factor 3 -0.0287982
WDR45B WD repeat domain 45B -0.0282819
HDLBP high density lipoprotein binding protein -0.0282218
TMSB10 thymosin beta 10 -0.027792
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0277047
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0275993
RPS15 ribosomal protein S15 -0.0269959
RPS8 ribosomal protein S8 -0.0268684
APOE apolipoprotein E -0.0258659
RPL32 ribosomal protein L32 -0.0250082
H1-0 H1.0 linker histone -0.0246493
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0238437
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0237959
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.023436
CANX calnexin -0.0233111
ZNF292 zinc finger protein 292 -0.0232822
RPL37A ribosomal protein L37a -0.0229133
STK17A serine/threonine kinase 17a -0.0223446
RPS5 ribosomal protein S5 -0.0222649
RYBP RING1 and YY1 binding protein -0.0222257
BIRC3 baculoviral IAP repeat containing 3 -0.0222025
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0221451
PLIN2 perilipin 2 -0.0221287
RPL36A ribosomal protein L36a -0.0219214
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0217569
CCDC186 coiled-coil domain containing 186 -0.0215324
LCN2 lipocalin 2 -0.0215228
APOA2 apolipoprotein A-II -0.0215192
RPL34 ribosomal protein L34 -0.021218
APOC1 apolipoprotein C-I -0.0210846
TLE4 transducin-like enhancer of split 4 -0.0205563
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0205235
RPLP1 ribosomal protein, large, P1 -0.0202881
ATXN1 ataxin 1 -0.020079
ZBTB10 zinc finger and BTB domain containing 10 -0.019453
RPL9 ribosomal protein L9 -0.0194207
LMNA lamin A/C -0.0191846
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0191034
SLC22A23 solute carrier family 22, member 23 -0.0189206
UGDH UDP-glucose 6-dehydrogenase -0.0188978
IQSEC1 IQ motif and Sec7 domain 1 -0.0185646
UGP2 UDP-glucose pyrophosphorylase 2 -0.0184369
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0181741
RPS6 ribosomal protein S6 -0.0181439
HBP1 HMG-box transcription factor 1 -0.0180692
TPI1 triosephosphate isomerase 1 -0.018068
KDM4B lysine (K)-specific demethylase 4B -0.0179799
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0178913
HMGA1 high mobility group AT-hook 1 -0.0178137
PMM2 phosphomannomutase 2 -0.0178077
HILPDA hypoxia inducible lipid droplet-associated -0.0177316
ENO1 enolase 1, (alpha) -0.0177297
GMDS GDP-mannose 4,6-dehydratase -0.0176912
GOLGB1 golgin B1 -0.017607
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0175636
ADM adrenomedullin -0.0175255
PDE8A phosphodiesterase 8A -0.0174197
RPL19 ribosomal protein L19 -0.0173413
CST3 cystatin C -0.0171924
EXT1 exostosin glycosyltransferase 1 -0.0171852
MXI1 MAX interactor 1, dimerization protein -0.0171153
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0170063
FAM53C family with sequence similarity 53, member C -0.016944
RPS24 ribosomal protein S24 -0.0168479
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -0.0164583
RPS10 ribosomal protein S10 -0.0163169
CSTB cystatin B (stefin B) -0.0163097
NAP1L1 nucleosome assembly protein 1-like 1 -0.0161749
EGFR epidermal growth factor receptor -0.0161109
RPL38 ribosomal protein L38 -0.0160337
RPL27 ribosomal protein L27 -0.0159622
TRA2A transformer 2 alpha homolog (Drosophila) -0.0158652
ZNF451 zinc finger protein 451 -0.0158218
GNAS GNAS complex locus -0.0157921
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0157084
TBCK TBC1 domain containing kinase -0.0156783
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0156676