Brimonidine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.175867
CEMIP cell migration inducing protein, hyaluronan binding 0.159043
ITGA6 integrin, alpha 6 0.114508
TNS4 tensin 4 0.110733
GPHN gephyrin 0.0892657
RNF43 ring finger protein 43 0.0886127
FAT1 FAT atypical cadherin 1 0.0871887
CD46 CD46 molecule, complement regulatory protein 0.0744354
NALF1 NALCN channel auxiliary factor 1 0.0720255
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0699461
CADPS Ca++-dependent secretion activator 0.0577524
ABHD2 abhydrolase domain containing 2 0.0519418
ARHGAP32 Rho GTPase activating protein 32 0.0518307
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0513966
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.050971
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0507176
KLF3 Kruppel-like factor 3 (basic) 0.0495843
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.048126
TRIM2 tripartite motif containing 2 0.0479336
PPARG peroxisome proliferator-activated receptor gamma 0.0467321
PTEN phosphatase and tensin homolog 0.0454581
PRSS3 protease, serine, 3 0.0452387
DSPP dentin sialophosphoprotein 0.0444677
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0444575
PTBP3 polypyrimidine tract binding protein 3 0.0433891
PTPRR protein tyrosine phosphatase, receptor type, R 0.0417221
KDM7A lysine (K)-specific demethylase 7A 0.0413701
TBC1D5 TBC1 domain family, member 5 0.0409485
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0397823
FOXP1 forkhead box P1 0.0368255
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0367422
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0356725
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.03447
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0337313
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0336955
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330834
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0329349
ITPRID2 ITPR interacting domain containing 2 0.0325031
NEBL nebulette 0.0320319
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0314477
ARL15 ADP-ribosylation factor-like 15 0.0310575
MBD5 methyl-CpG binding domain protein 5 0.0308544
MED13 mediator complex subunit 13 0.0307361
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0304205
RAB10 RAB10, member RAS oncogene family 0.0302423
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0299483
USP6NL USP6 N-terminal like 0.0297957
NFIA nuclear factor I/A 0.0297497
PELI1 pellino E3 ubiquitin protein ligase 1 0.029318
CALB1 calbindin 1, 28kDa 0.0292696
PRELID2 PRELI domain containing 2 0.029193
SMYD3 SET and MYND domain containing 3 0.0288542
TMEM45B transmembrane protein 45B 0.0286682
ESYT2 extended synaptotagmin-like protein 2 0.028662
SPRED1 sprouty-related, EVH1 domain containing 1 0.0286514
SERINC5 serine incorporator 5 0.0282966
ARHGAP26 Rho GTPase activating protein 26 0.0281108
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0280441
ABHD17C abhydrolase domain containing 17C 0.0275104
CTBP2 C-terminal binding protein 2 0.0274279
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0273096
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0272893
DPY19L1 dpy-19-like 1 (C. elegans) 0.027244
ANXA2 annexin A2 0.0272372
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0270634
BCL2L1 BCL2-like 1 0.0268718
PLS1 plastin 1 0.0262132
AVL9 AVL9 homolog (S. cerevisiase) 0.0260881
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0260427
PATJ PATJ crumbs cell polarity complex component 0.0257581
UBE2H ubiquitin-conjugating enzyme E2H 0.0256892
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0256285
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0255699
CDK6 cyclin-dependent kinase 6 0.0255558
INSIG1 insulin induced gene 1 0.0254588
CD44 CD44 molecule (Indian blood group) 0.0253923
NPSR1 neuropeptide S receptor 1 0.0252756
KMT2C lysine (K)-specific methyltransferase 2C 0.0252272
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0251908
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0251203
PKP2 plakophilin 2 0.0251109
ARB2A ARB2 cotranscriptional regulator A 0.0250045
TSC22D1 TSC22 domain family, member 1 0.0247355
ETNK1 ethanolamine kinase 1 0.0245643
MYOF myoferlin 0.024432
FTH1 ferritin, heavy polypeptide 1 0.0243909
WWC1 WW and C2 domain containing 1 0.0243875
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243667
ZNRF3 zinc and ring finger 3 0.0243276
SHROOM3 shroom family member 3 0.0242523
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0241599
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0241234
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.024115
PTCH1 patched 1 0.0240004
RREB1 ras responsive element binding protein 1 0.0239813
GMDS GDP-mannose 4,6-dehydratase 0.0238389
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0237763
SETD5 SET domain containing 5 0.0236209
ASPH aspartate beta-hydroxylase 0.0236201
MED13L mediator complex subunit 13-like 0.0235571

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.208865
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.164535
PTMA prothymosin, alpha -0.140644
TPT1 tumor protein, translationally-controlled 1 -0.140386
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137849
RPS6 ribosomal protein S6 -0.113237
RPL35A ribosomal protein L35a -0.10286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0949005
RPS8 ribosomal protein S8 -0.0835278
FTL ferritin, light polypeptide -0.0706486
RPL34 ribosomal protein L34 -0.0685458
RPS19 ribosomal protein S19 -0.0627651
RPLP1 ribosomal protein, large, P1 -0.0606916
RPL23 ribosomal protein L23 -0.0599697
VCL vinculin -0.0578683
RPL12 ribosomal protein L12 -0.0572651
RPL26 ribosomal protein L26 -0.0525359
ACTG1 actin gamma 1 -0.0510124
RPL36 ribosomal protein L36 -0.0500324
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0494385
S100P S100 calcium binding protein P -0.0488725
RPL9 ribosomal protein L9 -0.0481168
RPL19 ribosomal protein L19 -0.0470485
RPL31 ribosomal protein L31 -0.0459075
RPS25 ribosomal protein S25 -0.0451731
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0449403
RPL37A ribosomal protein L37a -0.0444629
RPLP2 ribosomal protein, large, P2 -0.0415975
RPL11 ribosomal protein L11 -0.0411877
RPS29 ribosomal protein S29 -0.0395277
RPS23 ribosomal protein S23 -0.0393926
RPS12 ribosomal protein S12 -0.0384921
RPS27A ribosomal protein S27a -0.0383426
TPM4 tropomyosin 4 -0.0378711
RPL5 ribosomal protein L5 -0.0375992
RPL32 ribosomal protein L32 -0.0372852
S100A9 S100 calcium binding protein A9 -0.0372201
RPL28 ribosomal protein L28 -0.0361351
S100A10 S100 calcium binding protein A10 -0.0356429
RPS3 ribosomal protein S3 -0.0355757
EXT1 exostosin glycosyltransferase 1 -0.035209
EIF1 eukaryotic translation initiation factor 1 -0.0345804
RPS21 ribosomal protein S21 -0.0345399
RPS24 ribosomal protein S24 -0.034087
RPS27 ribosomal protein S27 -0.0335396
RPS13 ribosomal protein S13 -0.0333932
RPL37 ribosomal protein L37 -0.0331817
RPL13A ribosomal protein L13a -0.0317247
RPL8 ribosomal protein L8 -0.0313738
RPLP0 ribosomal protein, large, P0 -0.0311085
MT2A metallothionein 2A -0.0310371
GRB10 growth factor receptor-bound protein 10 -0.0308454
AGR2 anterior gradient 2 -0.0303042
RPS11 ribosomal protein S11 -0.0299091
PIGR polymeric immunoglobulin receptor -0.029663
RPS14 ribosomal protein S14 -0.0294159
RPL35 ribosomal protein L35 -0.0293066
RPL7A ribosomal protein L7a -0.0292674
RPS5 ribosomal protein S5 -0.0292664
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0290762
RPL7 ribosomal protein L7 -0.0283776
TFF1 trefoil factor 1 -0.0279715
EMP1 epithelial membrane protein 1 -0.0278208
RPS10 ribosomal protein S10 -0.0273846
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0270509
RPL18 ribosomal protein L18 -0.0268831
ISG15 ISG15 ubiquitin-like modifier -0.0263642
KLF6 Kruppel-like factor 6 -0.0262721
RACK1 receptor for activated C kinase 1 -0.0262498
MBNL1 muscleblind-like splicing regulator 1 -0.0261664
RPS16 ribosomal protein S16 -0.0252018
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0251641
S100A6 S100 calcium binding protein A6 -0.0248717
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0246198
ATF4 activating transcription factor 4 -0.0242898
RPS17 ribosomal protein S17 -0.0240363
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0237304
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0233264
RPL27 ribosomal protein L27 -0.023133
MYO1E myosin IE -0.0227856
CALR calreticulin -0.0227611
RPL38 ribosomal protein L38 -0.0226176
IER3 immediate early response 3 -0.0223739
P4HB prolyl 4-hydroxylase, beta polypeptide -0.022269
GNAS GNAS complex locus -0.021783
ANXA1 annexin A1 -0.0216301
RPS20 ribosomal protein S20 -0.021545
CSTB cystatin B (stefin B) -0.021416
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0209437
KLF5 Kruppel-like factor 5 (intestinal) -0.0205244
USP53 ubiquitin specific peptidase 53 -0.0204729
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0204563
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0203223
SLC38A2 solute carrier family 38, member 2 -0.0203214
RPL36A ribosomal protein L36a -0.020282
LMNA lamin A/C -0.0201534
TXNIP thioredoxin interacting protein -0.0199086
RIGI RNA sensor RIG-I -0.0197874
RPL27A ribosomal protein L27a -0.0194753
RPL36AL ribosomal protein L36a-like -0.0193769