Brimonidine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Brimonidine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Brimonidine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.22942
PSD3 pleckstrin and Sec7 domain containing 3 0.175582
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0836615
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0772514
MT1E metallothionein 1E 0.0696545
KMT2E lysine (K)-specific methyltransferase 2E 0.0679175
WWTR1 WW domain containing transcription regulator 1 0.0615819
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.05984
TM4SF1 transmembrane 4 L six family member 1 0.057682
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0567325
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0563177
TXNRD1 thioredoxin reductase 1 0.0545466
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0543731
CAPRIN2 caprin family member 2 0.0529337
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0525374
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0524144
ANGPTL4 angiopoietin-like 4 0.0513377
MT1X metallothionein 1X 0.05065
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0434698
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0427187
VMP1 vacuole membrane protein 1 0.0423663
TSC22D1 TSC22 domain family, member 1 0.0422284
BCAR3 breast cancer anti-estrogen resistance 3 0.0418065
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0405672
BIRC3 baculoviral IAP repeat containing 3 0.0398519
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0392236
TP63 tumor protein p63 0.0382648
RTN4 reticulon 4 0.0377183
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0376158
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0376057
NPAS2 neuronal PAS domain protein 2 0.0356438
EMP1 epithelial membrane protein 1 0.0353411
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0346544
FOSL1 FOS-like antigen 1 0.0340157
SDK1 sidekick cell adhesion molecule 1 0.0328747
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0328702
GCLM glutamate-cysteine ligase, modifier subunit 0.0322106
ZMYND8 zinc finger, MYND-type containing 8 0.0315823
FMNL2 formin-like 2 0.0304738
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0299737
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0287415
PRELID2 PRELI domain containing 2 0.0285216
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0283176
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0280079
EZR ezrin 0.0278969
SPRED2 sprouty-related, EVH1 domain containing 2 0.0275744
F2R coagulation factor II (thrombin) receptor 0.0274419
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0270577
ANKRD12 ankyrin repeat domain 12 0.0267775
RAD51B RAD51 paralog B 0.0264615
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0264386
FERMT1 fermitin family member 1 0.0259355
DNER delta/notch-like EGF repeat containing 0.0258425
PDE4D phosphodiesterase 4D, cAMP-specific 0.0250058
CSNK1A1 casein kinase 1, alpha 1 0.0245507
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0240186
EREG epiregulin 0.0235291
PYGL phosphorylase, glycogen, liver 0.0232739
SDCCAG8 serologically defined colon cancer antigen 8 0.0231464
CDCP1 CUB domain containing protein 1 0.0229981
IFI6 interferon, alpha-inducible protein 6 0.0229429
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0228851
ANTXR2 anthrax toxin receptor 2 0.0227291
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0219054
SPIDR scaffolding protein involved in DNA repair 0.0216212
RTTN rotatin 0.0216081
SVIL supervillin 0.0215129
PDE10A phosphodiesterase 10A 0.0212868
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0212366
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0211864
TUBB6 tubulin, beta 6 class V 0.0211391
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0210517
POTEF POTE ankyrin domain family, member F 0.020709
NT5E 5'-nucleotidase, ecto (CD73) 0.0206496
TRIP12 thyroid hormone receptor interactor 12 0.0202292
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0201641
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0201492
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0201184
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0200861
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.019739
S100A6 S100 calcium binding protein A6 0.0196483
IFITM1 interferon induced transmembrane protein 1 0.0196091
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0195078
PLAUR plasminogen activator, urokinase receptor 0.0194379
MSN moesin 0.0192474
MEF2A myocyte enhancer factor 2A 0.0191646
PRDX1 peroxiredoxin 1 0.019033
AGTPBP1 ATP/GTP binding protein 1 0.0189056
SRGN serglycin 0.0188433
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0184987
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.018457
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0181797
IL6ST interleukin 6 signal transducer 0.018168
KTN1 kinectin 1 (kinesin receptor) 0.0181544
AREG amphiregulin 0.0181457
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0180736
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0179047
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0178749
UBXN4 UBX domain protein 4 0.0178121
BMERB1 bMERB domain containing 1 0.0178115

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.210899
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.207561
PTMA prothymosin, alpha -0.15843
TMSB4X thymosin beta 4, X-linked -0.085973
CANX calnexin -0.0820801
TMSB10 thymosin beta 10 -0.0759138
DLG1 discs, large homolog 1 (Drosophila) -0.0674006
GARS1 glycyl-tRNA synthetase 1 -0.0524602
CALR calreticulin -0.0488634
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0475434
KDM3A lysine (K)-specific demethylase 3A -0.0460944
HDLBP high density lipoprotein binding protein -0.0442676
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0424436
PTPRF protein tyrosine phosphatase, receptor type, F -0.0370788
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0370732
OGA O-GlcNAcase -0.0362215
CD44 CD44 molecule (Indian blood group) -0.03605
TMEM123 transmembrane protein 123 -0.0356607
EPHA4 EPH receptor A4 -0.0352207
AHNAK AHNAK nucleoprotein -0.0351255
EFNA5 ephrin-A5 -0.0345727
SPAG9 sperm associated antigen 9 -0.0315332
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0314823
LMAN1 lectin, mannose-binding, 1 -0.0309511
PDIA6 protein disulfide isomerase family A, member 6 -0.0305535
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0302094
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0292627
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0292285
EIF1 eukaryotic translation initiation factor 1 -0.0289806
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0288394
ZNF217 zinc finger protein 217 -0.0285422
IARS1 isoleucyl-tRNA synthetase 1 -0.0282337
TRIO trio Rho guanine nucleotide exchange factor -0.0279449
ARF1 ADP-ribosylation factor 1 -0.027155
GOLGA4 golgin A4 -0.0266431
SET SET nuclear proto-oncogene -0.0263588
PDIA3 protein disulfide isomerase family A, member 3 -0.0260182
WDR45B WD repeat domain 45B -0.0260032
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0259048
EEF2 eukaryotic translation elongation factor 2 -0.0257218
NAP1L1 nucleosome assembly protein 1-like 1 -0.0256729
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0255474
TPT1 tumor protein, translationally-controlled 1 -0.0253054
CAVIN1 caveolae associated protein 1 -0.0250348
ACTG1 actin gamma 1 -0.024824
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0245696
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0236084
GNAS GNAS complex locus -0.023584
SEC31A SEC31 homolog A (S. cerevisiae) -0.0232014
UBE3C ubiquitin protein ligase E3C -0.0231682
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.022931
KIF5B kinesin family member 5B -0.0223391
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0222686
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0218803
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0218525
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0218303
RAD21 RAD21 homolog (S. pombe) -0.0214645
MORF4L2 mortality factor 4 like 2 -0.0213945
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0213203
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.021223
YME1L1 YME1-like 1 ATPase -0.0212049
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0211869
EHBP1 EH domain binding protein 1 -0.0211202
WASF2 WAS protein family, member 2 -0.0211009
NPR2 natriuretic peptide receptor 2 -0.0210203
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0209563
RBM39 RNA binding motif protein 39 -0.0208791
RPS8 ribosomal protein S8 -0.0203441
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0202042
PGK1 phosphoglycerate kinase 1 -0.0202009
MYOF myoferlin -0.0201066
AHNAK2 AHNAK nucleoprotein 2 -0.0200018
WSB1 WD repeat and SOCS box containing 1 -0.0198562
RPL35A ribosomal protein L35a -0.0196343
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.019617
FUS FUS RNA binding protein -0.0195793
MAP4 microtubule-associated protein 4 -0.0193912
RPL26 ribosomal protein L26 -0.0192542
RPS27A ribosomal protein S27a -0.0191553
RLF rearranged L-myc fusion -0.0191041
VDAC1 voltage-dependent anion channel 1 -0.0188565
EPB41 erythrocyte membrane protein band 4.1 -0.0186729
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0185878
CSDE1 cold shock domain containing E1, RNA-binding -0.018575
NUP58 nucleoporin 58 -0.0185578
YBX1 Y box binding protein 1 -0.0182667
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0182234
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0182007
RIOK3 RIO kinase 3 -0.018157
TTC3 tetratricopeptide repeat domain 3 -0.0181073
TFRC transferrin receptor -0.0180451
LARS1 leucyl-tRNA synthetase 1 -0.0178318
SRP54 signal recognition particle 54kDa -0.0178265
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0178241
RPL4 ribosomal protein L4 -0.0177366
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0171256
SEC63 SEC63 homolog (S. cerevisiae) -0.0171003
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0170876
HOOK2 hook microtubule-tethering protein 2 -0.0170122
COPB1 coatomer protein complex, subunit beta 1 -0.0169876