| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Brimonidine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Brimonidine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.266243 |
| TXNRD1 | thioredoxin reductase 1 | 0.115039 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.110265 |
| OSMR | oncostatin M receptor | 0.0847339 |
| CES1 | carboxylesterase 1 | 0.0816507 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0787483 |
| LAMA4 | laminin, alpha 4 | 0.0767788 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0676755 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0625368 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0562304 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0550877 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0525613 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0477703 |
| LAMC2 | laminin, gamma 2 | 0.0435813 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0373508 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0352875 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0344968 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0328198 |
| LMO7 | LIM domain 7 | 0.032634 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0324396 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0316177 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0304742 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0300374 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0297202 |
| EFNA5 | ephrin-A5 | 0.0291534 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0291437 |
| SYAP1 | synapse associated protein 1 | 0.0289546 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0267126 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0266638 |
| FRY | furry homolog (Drosophila) | 0.0266293 |
| SLTM | SAFB-like, transcription modulator | 0.0265628 |
| CCNL1 | cyclin L1 | 0.026529 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0262848 |
| MYO1B | myosin IB | 0.0249061 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0245588 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0239865 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0239106 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0221998 |
| RNF149 | ring finger protein 149 | 0.0218333 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0205549 |
| TJP1 | tight junction protein 1 | 0.0203752 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0199892 |
| ITGB5 | integrin, beta 5 | 0.0199463 |
| KYNU | kynureninase | 0.0197362 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0195921 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0194211 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0193566 |
| JMJD1C | jumonji domain containing 1C | 0.0190633 |
| FOXP1 | forkhead box P1 | 0.0187531 |
| BPTF | bromodomain PHD finger transcription factor | 0.0186887 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0186295 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0185946 |
| FRMD4B | FERM domain containing 4B | 0.0184519 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0180403 |
| TES | testin LIM domain protein | 0.0178349 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0175055 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0174051 |
| MGAT4C | MGAT4 family, member C | 0.0171482 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.017094 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0170837 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0169576 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0161685 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0159739 |
| NGLY1 | N-glycanase 1 | 0.0159737 |
| RTN4 | reticulon 4 | 0.0159707 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0159147 |
| NDRG1 | N-myc downstream regulated 1 | 0.0157986 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0153416 |
| SPAG9 | sperm associated antigen 9 | 0.015172 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0150874 |
| MKI67 | marker of proliferation Ki-67 | 0.0150362 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0142492 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.014245 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0142288 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0140275 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0140074 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0138244 |
| PPP6R2 | protein phosphatase 6, regulatory subunit 2 | 0.0137744 |
| TSC22D2 | TSC22 domain family, member 2 | 0.013615 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0135963 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0134346 |
| AREG | amphiregulin | 0.013169 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0131624 |
| EGR1 | early growth response 1 | 0.0131278 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0130993 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0130856 |
| CPE | carboxypeptidase E | 0.0129494 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0128968 |
| ZNF292 | zinc finger protein 292 | 0.0128934 |
| WDR26 | WD repeat domain 26 | 0.0128097 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0127569 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0126783 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0125118 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.0124822 |
| RIN2 | Ras and Rab interactor 2 | 0.0123571 |
| PHF3 | PHD finger protein 3 | 0.0123348 |
| TOP1 | topoisomerase (DNA) I | 0.0122856 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0120847 |
| PTEN | phosphatase and tensin homolog | 0.012045 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0120026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16115 |
| TMSB10 | thymosin beta 10 | -0.128493 |
| ASPH | aspartate beta-hydroxylase | -0.116331 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.106943 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0969942 |
| UBC | ubiquitin C | -0.0866572 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.084759 |
| FTL | ferritin, light polypeptide | -0.0845887 |
| EGFR | epidermal growth factor receptor | -0.0757729 |
| RPS3 | ribosomal protein S3 | -0.0755906 |
| PTMA | prothymosin, alpha | -0.0733699 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0693761 |
| INTS6 | integrator complex subunit 6 | -0.0625511 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0595222 |
| ENO1 | enolase 1, (alpha) | -0.0546562 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0515954 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0501482 |
| RPS27A | ribosomal protein S27a | -0.0487523 |
| SEC61G | Sec61 gamma subunit | -0.0480882 |
| RPLP1 | ribosomal protein, large, P1 | -0.0476234 |
| RPS8 | ribosomal protein S8 | -0.0469105 |
| MYOF | myoferlin | -0.0455586 |
| RPL35A | ribosomal protein L35a | -0.0452974 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0444706 |
| ACTG1 | actin gamma 1 | -0.0439048 |
| RPS25 | ribosomal protein S25 | -0.0435458 |
| RPL37A | ribosomal protein L37a | -0.0411696 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0410936 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0407265 |
| RPL31 | ribosomal protein L31 | -0.04005 |
| RPS6 | ribosomal protein S6 | -0.0393179 |
| SCEL | sciellin | -0.0381132 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0381006 |
| MT2A | metallothionein 2A | -0.0380464 |
| PKM | pyruvate kinase, muscle | -0.0371185 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0365485 |
| S100A10 | S100 calcium binding protein A10 | -0.03411 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0338734 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0327408 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0323386 |
| RPL8 | ribosomal protein L8 | -0.0322844 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0316207 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0312347 |
| RPL12 | ribosomal protein L12 | -0.0308889 |
| SMAD3 | SMAD family member 3 | -0.0307968 |
| RPL19 | ribosomal protein L19 | -0.0302985 |
| RPS19 | ribosomal protein S19 | -0.0299043 |
| RPL11 | ribosomal protein L11 | -0.0293431 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0287253 |
| RPS29 | ribosomal protein S29 | -0.0286525 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.027197 |
| RPL23 | ribosomal protein L23 | -0.0269648 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0268857 |
| HOMER1 | homer scaffolding protein 1 | -0.0265407 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0264425 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0263383 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0261004 |
| RPS24 | ribosomal protein S24 | -0.0260557 |
| RPS23 | ribosomal protein S23 | -0.026026 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0259203 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0258642 |
| GRAMD1B | GRAM domain containing 1B | -0.0256191 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.025595 |
| RPL7 | ribosomal protein L7 | -0.0254044 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0253312 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.025314 |
| RPL5 | ribosomal protein L5 | -0.0253045 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0252416 |
| FLNB | filamin B, beta | -0.0251895 |
| RPS21 | ribosomal protein S21 | -0.0237912 |
| KRT7 | keratin 7, type II | -0.0236654 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0236653 |
| FUS | FUS RNA binding protein | -0.0233886 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0232662 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0231348 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0229147 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0224329 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0222314 |
| IER3 | immediate early response 3 | -0.0220511 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.021978 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0217699 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.021752 |
| RPS17 | ribosomal protein S17 | -0.0216229 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0216148 |
| RPL34 | ribosomal protein L34 | -0.0215895 |
| ANXA2 | annexin A2 | -0.0213273 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0210885 |
| RPS27 | ribosomal protein S27 | -0.0210805 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0210026 |
| RPS12 | ribosomal protein S12 | -0.0208265 |
| RPLP0 | ribosomal protein, large, P0 | -0.0206817 |
| PCBP2 | poly(rC) binding protein 2 | -0.0206304 |
| RPS4X | ribosomal protein S4, X-linked | -0.0205286 |
| HDLBP | high density lipoprotein binding protein | -0.020497 |
| RPL37 | ribosomal protein L37 | -0.0204924 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0204448 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.020358 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0203287 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0203046 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0198993 |
